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A total of 520 cell-cell interactions
Source gene Source gene alias Target gene Target gene alias Interaction name Interaction type Signaling type Source cell Literature source cell Target cell Literature target cell Species Source gene cofactor Source gene cofactor function Target gene cofactor Target gene cofactor function Effector Effector function Pathway name Phenotype Mode of Action Source tissue Target tissue Source cell pathology Target cell pathology Source cell perturbation Target cell perturbation Source cell stage Target cell stage Patient Pathology Literature patient Pathology DB Source PMID Journal title Journal name Authors Publication year
Acetylcholine - Musacarinic receptor - Acetylcholine_Musacarinic receptor Ligand-receptor Paracrine Neuron Vagal nerve Macrophage Hepatic macrophage Mouse - - - - - - Musacarinic - - Brain Liver Normal Normal - - - - - - pubmed 30546054
Vagus-macrophage-hepatocyte link promotes post-injury liver ...
 Nature Communications Tomohito Izumi et al. 2018
ANG - EGFR - ANG_EGFR Ligand-receptor Paracrine Endothelial cell Endothelial cell TEC Tumor-associated Endothelial cell Human,Mouse - - - - ANG Activation EGFR Migration,Invasion,Tumor initiation,Tumor development Activation,Activation,Activation,Activation Pancreas Pancreas Normal Cancer-associated - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 29606349
Angiogenin/ribonuclease 5 is an EGFR ligand and a serum biom...
 Cancer Cell Ying-Nai Wang et al. 2018
ANG - EGFR - ANG_EGFR Ligand-receptor Autocrine TEC Tumor-associated endothelial cell TEC Tumor-associated Endothelial cell Human,Mouse - - - - ANG Activation EGFR Migration,Invasion,Tumor initiation,Tumor development Activation,Activation,Activation,Activation Pancreas Pancreas Cancer-associated Cancer-associated - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 29606349
Angiogenin/ribonuclease 5 is an EGFR ligand and a serum biom...
 Cancer Cell Ying-Nai Wang et al. 2018
ANGPT1 - TEK Tie2 ANGPT1_TEK Ligand-receptor Autocrine Glial cell Glioblastoma cell Glial cell Glioblastoma cell Human,Mouse - - - - ANGPT1 Activation ANGPT Survival,Proliferation Activation,Activation Brain Brain Malignant Malignant - - - - Glioblastoma Glioblastoma pubmed 31763674
ΔNp73/ETS2 complex drives glioblastoma pathogenesis— targeti...
 Neuro-Oncology Maren Cam et al. 2020
ANGPT1 - TEK Tie2 ANGPT1_TEK Ligand-receptor Paracrine Glial cell Glioblastoma cell Endothelial cell Endothelial cell Human,Mouse - - - - - - ANGPT Angiogenesis Inhibition Brain Brain Malignant Normal - - - - Glioblastoma Glioblastoma pubmed 31763674
ΔNp73/ETS2 complex drives glioblastoma pathogenesis— targeti...
 Neuro-Oncology Maren Cam et al. 2020
ANXA1 - FPR1 - ANXA1_FPR1 Ligand-receptor Autocrine Malignant cell Castration-resistant prostate cancer cell Malignant cell Castration-resistant prostate cancer cell Human - - - - IL6,EGFR Activation,Activation ANNEXIN Proliferation Inhibition Prostate Prostate Malignant Malignant - - - - Castration-resistant Prostate Cancer Castration-resistant Prostate Cancer pubmed 32858191
Annexin A1 promotes the nuclear localization of the epiderma...
 The international journal of biochemistry & cell biology Sara Teixeira SoaresMota et al. 2020
APLN Adipokine Apelin APLNR APJ APLN_APLNR Ligand-receptor Paracrine Adipocyte Omental adipocyte Malignant cell Ovarian cancer cell Human,Mouse - - F13A1 APLN inhibition receptor CD36 Activation APELIN Modulating lipid uptake,Metastasis Activation,Activation Embryo Ovary Normal Malignant - - - - Ovarian Cancer Ovarian Cancer pubmed 34172534
Adipokine Apelin/APJ Pathway Promotes Peritoneal Disseminati...
 Molecular cancer research Samrita Dogra et al. 2021
ASPN Asporin CD44 - ASPN_CD44 Ligand-receptor Paracrine Stellate cell Activated pancreatic stellate cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - ASPN Invasion,Migration Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 28400334
Asporin promotes pancreatic cancer cell invasion and migrati...
 Cancer letters Lili Wang et al. 2017
ASPN Asporin CD44 - ASPN_CD44 Ligand-receptor Autocrine Malignant cell Pancreatic cancer cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - ASPN EMT,Invasion,Migration Activation,Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 28400334
Asporin promotes pancreatic cancer cell invasion and migrati...
 Cancer Letters Lili Wang et al. 2017
ASPN Asporin CD44 - ASPN_CD44 Ligand-receptor Paracrine Stellate cell Pancreatic stellate cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - ASPN EMT,Invasion,Migration Activation,Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 28400334
Asporin promotes pancreatic cancer cell invasion and migrati...
 Cancer Letters Lili Wang et al. 2017
BAG3 - IFITM2 IFITM-2 BAG3_IFITM2 Ligand-receptor Paracrine Malignant cell Pancreatic ductal adenocarcinoma cell Macrophage Macrophage Human - - - - Cytokine Activation BAG Tumor growth,Metastasis Activation,Activation Pancreas Pancreas Malignant Normal - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 28864347
Role of BAG3 in cancer progression: A therapeutic opportunit...
 Seminars in Cell & Developmental Biology Margot De Marco et al. 2018
BDNF - ERBB2 - BDNF_ERBB2 Ligand-receptor Paracrine Astrocyte Astrocyte Malignant cell Brain metastatic breast cancer cell Human,Mouse - - - - - - BDNF Proliferation Inhibition Brain Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 28446206
Cooperation of neurotrophin receptor TrkB and Her2 in breast...
 Breast Cancer Research Cecilia Choy et al. 2017
BDNF - NTRK2 TrkB BDNF_NTRK2 Ligand-receptor Paracrine Astrocyte Astrocyte Malignant cell Triple Negative Breast Cancer cell Human,Mouse - - - - BDNF Activation BDNF Invasion,Migration,Metastasis Activation,Activation,Activation Brain Breast Normal Malignant - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 30796353
Estradiol induces BDNF/TrkB signaling in triple-negative bre...
 Oncogene Maria J Contreras-Zárate et al. 2019
BDNF - NTRK2 TrkB BDNF_NTRK2 Ligand-receptor Autocrine Malignant cell Triple-negative breast cancer cell Malignant cell Triple Negative Breast Cancer cell Human,Mouse - - - - BDNF Activation BDNF Invasion,Migration,Brain metastasis Activation,Activation,Activation Breast Breast Malignant Malignant - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 30796353
Estradiol induces BDNF/TrkB signaling in triple-negative bre...
 Oncogene Maria J Contreras-Zárate et al. 2019
BDNF - TRK2 - BDNF_TRK2 Ligand-receptor Paracrine Astrocyte Astrocyte Malignant cell Brain metastatic breast cancer cell Human,Mouse - - - - - - BDNF Proliferation Inhibition Brain Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 28446206
Cooperation of neurotrophin receptor TrkB and Her2 in breast...
 Breast Cancer Research Cecilia Choy et al. 2017
Bmp - Bmpr1a - Bmp_Bmpr1a Ligand-receptor Paracrine Mesenchymal cell Intravillus and intercrypt mesenchymal cell Stem cell Lgr5+ stem cell Mouse - - - - - - BMP Tumor initiation Inhibition Intestine Intestine Normal Normal - - - - - - pubmed 28059064
BMP restricts stemness of intestinal Lgr5+ stem cells by dir...
 Nature communications Zhen Qi et al. 2017
BMP2 - BMPR2 - BMP2_BMPR2 Ligand-receptor Paracrine TAN Tumor-associated Neutrophil Cancer stem cell Hepatocellular carcinoma stem-like cell Human - - - - CXCL5 Activation BMP Proliferation,Invasion Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30933361
A Positive Feedback Loop between Cancer Stem-Like Cells and ...
 Hepatology Shao‐Lai Zhou et al. 2019
BMP4 BMP-4 BMPR1A - BMP4_BMPR1A Ligand-receptor Autocrine Malignant cell Colorectal cancer cell Malignant cell Colorectal cancer cell Human,Mouse - - - - - - BMP Survival Activation Colorectum Colorectum Malignant Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 28611046
Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorec...
 Cancer research Yuichiro Yokoyama et al. 2017
BMP4 - BMPR2 - BMP4_BMPR2 Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SMAD7 Activation BMP Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 31941699
Activation of Canonical BMP4-SMAD7 Signaling Suppresses Brea...
 Cancer research Bedrich L Eckhardt et al. 2020
BMP4 BMP-4 BMPR2A - BMP4_BMPR2A Ligand-receptor Autocrine Malignant cell Colorectal cancer cell Malignant cell Colorectal cancer cell Human,Mouse - - - - - - BMP Survival Activation Colorectum Colorectum Malignant Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 28611046
Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorec...
 Cancer research Yuichiro Yokoyama et al. 2017
C3 - C3ar1 - C3_C3ar1 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell MDSC Myeloid-derived suppressor cell Mouse - - - - IL10 Activation COMPLEMENT T cell immunity Inhibition Liver Liver Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33633112
PIWIL1 governs the crosstalk of cancer cell metabolism and i...
 Signal Transduction and Targeted Therapy Ning Wang et al. 2021
C3 C3a C3AR1 - C3_C3AR1 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Prostate cancer cell Human,Mouse - - - - BCL2 Activation COMPLEMENT Progression,Docetaxel resistance Activation,Activation Prostate Prostate Cancer-associated Malignant - - - - Prostate Cancer Prostate Cancer pubmed 32238563
Cancer epithelial-derived mitochondrial DNA is a targetable ...
 Proceedings of the National Academy of Sciences of the USA Subhash Haldar et al. 2020
C5 C5a C5AR1 - C5_C5AR1 Ligand-receptor Paracrine Stem cell Mesenchymal stemlike cell Malignant cell Glioblastoma cell Human,Mouse - - - - ZEB1 Activation COMPLEMENT Invasion Inhibition Brain Brain Normal Malignant - - - - Glioblastoma Glioblastoma pubmed 32179921
Crosstalk between GBM cells and mesenchymal stemlike cells p...
 Neuro-Oncology Eun-Jung Lim et al. 2020
CCL1 - CCR8 - CCL1_CCR8 Ligand-receptor Paracrine TAM Tumor-infiltrating macrophage Malignant cell Hepatoma cell Human - - - - PKM Activation PI3K PKM2 excretion,Monocyte-to-Macrophage differentiation Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 32470318
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Different...
 Molecular cell Pei-Pei Hou et al. 2020
CCL1 - CCR8 - CCL1_CCR8 Ligand-receptor Paracrine Cancer stem cell Breast cancer stem cell T cell CD4+ CD25+ Treg Human,Mouse - - - - - - CCL Stemness Inhibition Breast Breast Malignant Normal - - - CD4+CD25+ Treg Breast Cancer Breast Cancer pubmed 29044882
Sox2 Communicates with Tregs Through CCL1 to Promote the Ste...
 Stem cells Yingxi Xu et al. 2017
CCL11 - CCR3 - CCL11_CCR3 Ligand-receptor Paracrine MDSC Myeloid-derived suppressor cell Malignant cell Non small cell lung cancer cell Human,Mouse - - - - CDH2,VIM,MMP Activation CCL Metastasis Inhibition Lung Lung Normal Malignant - - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 33452453
Myeloid-derived suppressor cells promote lung cancer metasta...
 Oncogene Shouheng Lin et al. 2021
Ccl17 - Ccr4 - Ccl17_Ccr4 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell HIC1-deleted breast cancer cell Mouse - - - - - - CCL Migration,Progression,Metastasis Activation,Activation,Activation Breast Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 30204129
HIC1 deletion promotes breast cancer progression by activati...
 The Journal of Clinical Investication Yingying Wang et al. 2018
CCL19 - CCR7 - CCL19_CCR7 Ligand-receptor Paracrine Malignant cell Colorectal cancer cell Endothelial cell Endothelial cell Human,Mouse - - - - miR206 Activation CCL Angiogenesis Inhibition Colon Colon Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30250188
CCL19 suppresses angiogenesis through promoting miR-206 and ...
 Cell Death and Disease Zhuoqing Xu et al. 2018
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Macrophage Alternatively activated macrophage Epithelial cell Pancreatic intraepithelial neoplasia (PanIN) cell Human,Mouse - - - - - - - Pancreatic fibrogenesis,Tumorigenesis Activation,Activation Pancreas Pancreas Normal Normal - - M2 - Pancreatic Cancer Pancreatic Cancer pubmed 28514653
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio...
 Cell reports Geou-YarhLiou et al. 2017
CCL2 MCP1 CCR2 - CCL2_CCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Monocyte Circulating CD14+ CCR2+ Monocyte Human - - - - - - CCL Migration Inhibition Lung Lung Cancer-associated Normal - - - CD14+ Lung squamous cell carcinoma (LSCC)  Lung squamous cell carcinoma (LSCC)  pubmed 32075803
Cancer-Associated Fibroblasts Promote Immunosuppression by I...
 Cancer immunology research Handan Xiang et al. 2020
Ccl2 - Ccr2 - Ccl2_Ccr2 Ligand-receptor Paracrine Malignant cell Bladder cancer cell TAM Tumor-associated Macrophage Mouse - - - - VEGFC Activation CCL Lymphangiogenesis,Lymphatic metastasis Activation,Activation Bladder Bladder Malignant Cancer-associated - - - - LN-positive bladder cancer LN-positive bladder cancer pubmed 30237493
LNMAT1 promotes lymphatic metastasis of bladder cancer via C...
 Nature communications Changhao Chen et al. 2018
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Mural cell Mural cell Malignant cell Tumor cell Human,Mouse - - - - - - CCL Proliferation Inhibition Blood Lung Normal Malignant Mural-β3-integrin loss - - - Lung Cancer Lung Cancer pubmed 32473126
Cancer Burden is controlled by mural cell-b3-integrin regula...
 Cell Ping-Pui Wong et al. 2020
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Mural cell Mural cell Melanocyte Tumor cell Human,Mouse - - - - - - CCL Proliferation Inhibition Blood Skin Normal Malignant Mural-β3-integrin loss - - - Cutaneous melanoma Cutaneous melanoma pubmed 32473126
Cancer Burden is controlled by mural cell-b3-integrin regula...
 Cell Ping-Pui Wong et al. 2020
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Mural cell Mural cell Malignant cell Tumor cell Human,Mouse - - - - - - CCL Proliferation Inhibition Blood Breast Normal Malignant Mural-β3-integrin loss - - - ER+ breast cancer ER+ breast cancer pubmed 32473126
Cancer Burden is controlled by mural cell-b3-integrin regula...
 Cell Ping-Pui Wong et al. 2020
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Breast cancer cell Human - - - - - - CCL Endocrine resistance Activation Breast Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 31710162
Tumor-associated macrophages secrete CC-chemokine ligand 2 a...
 Cancer Sceince Dongbo Li et al. 2020
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Malignant cell Lung metastatic cell Endothelial cell Endothelial cell Human,Mouse - - - - CDH2,VIM,MMP Activation CCL Metastasis Inhibition Lung Lung Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 29084208
Transcription factor c-Myb inhibits breast cancer lung metas...
 Oncogene L Knopfová et al. 2018
CCL2 - CCR2 - CCL2_CCR2 Ligand-receptor Paracrine Lymphocyte B cell acute lymphoblastic leukemia cell Stromal cell Bone marrow-derived mesenchymal stromal cell Human,Mouse - - - - POSTN Activation CCL - - Blood Bone marrow Malignant Normal - - - - B cell acute lymphoblastic leukemia B cell acute lymphoblastic leukemia pubmed 30726736
Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo...
 Cell Reports Zhenling Ma et al. 2019
CCL20 - CCR6 - CCL20_CCR6 Ligand-receptor Paracrine Malignant cell Pancreatic ductal adenocarcinoma cell T cell Th17 cell Human,Mouse - - - - - - CCL Invasion,Proliferation Inhibition Pancreas Pancreas Malignant Normal - - - T helper 17 Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 31561620 NF-κB Dependent Chemokine Signaling in Pancreatic Cancer Cancers Claudia Geismann et al. 2019
CCL20 - CCR6 - CCL20_CCR6 Ligand-receptor Paracrine Malignant cell Pancreatic ductal adenocarcinoma cell Dendritic cell Dendritic cell Human,Mouse - - - - - - CCL Invasion,Proliferation Inhibition Pancreas Pancreas Malignant Normal - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 31561620 NF-κB Dependent Chemokine Signaling in Pancreatic Cancer Cancers Claudia Geismann et al. 2019
CCL21 - CCR7 - CCL21_CCR7 Ligand-receptor Paracrine Endothelial cell Lymphatic endothelial cell Malignant cell Oral squamous cell carcinoma cell Human - - - - PROM1,CD44,ALDH1A1 Activation,Activation,Activation CCL Stemness,Chemoresistance Activation,Activation Lymph Oral Normal Malignant - - - - Oral squamous cell carcinoma Oral squamous cell carcinoma pubmed 32017846
CCL21/CCR7 interaction promotes EMT and enhances the stemnes...
 Journal of cellular physiology Yang Chen et al. 2020
CCL21 - CCR7 - CCL21_CCR7 Ligand-receptor Paracrine Endothelial cell Lymphatic endothelial cell Malignant cell Oral squamous cell carcinoma cell Human - - - - CDH1,CDH2,VIM Activation,Activation,Activation CCL Migration,Invasion Activation,Activation Lymph Oral Normal Malignant - - - - Oral squamous cell carcinoma Oral squamous cell carcinoma pubmed 32017846
CCL21/CCR7 interaction promotes EMT and enhances the stemnes...
 Journal of cellular physiology Yang Chen et al. 2020
CCL4 MIP-1β CCR5 - CCL4_CCR5 Ligand-receptor Paracrine Macrophage Alternatively activated macrophage Mesothelial cell Mesothelial cell Human,Mouse - - - - SELP Activation CCL P-selectin expression Inhibition Ovary Peritoneum Normal Normal - - - - High grade serous ovarian cancer (HGSOC) High grade serous ovarian cancer (HGSOC) pubmed 29739756
Alternatively-Activated Macrophages Upregulate Mesothelial E...
 Cancer research Molly J Carroll et al. 2018
CCL4 - CCR5 - CCL4_CCR5 Ligand-receptor Paracrine T cell CD8+ T cell Glial cell Microglia Human,Mouse - - - - CCL5 Activation CCL - - Brain Brain Normal Normal - - CD8+ - Glioma Glioma pubmed 32358581
Midkine activation of CD8 + T cells establishes a neuron-imm...
 Nature communications Xiaofan Guo et al. 2020
CCL5 - CCR5 - CCL5_CCR5 Ligand-receptor Paracrine Malignant cell Circulating tumor cell T cell Regulatory T cell Human,Mouse - - - - TGFB1 Activation CCL Metastasis Inhibition Liver Liver Malignant Normal - - - T Regulatory Hepatocellular carcinoma Hepatocellular carcinoma pubmed 34215748
Dissecting spatial heterogeneity and the immune-evasion mech...
 Nature Communications Yun-Fan Sun et al. 2021
CCL5 - CCR5 - CCL5_CCR5 Ligand-receptor Paracrine Pericyte Pericyte Malignant cell Glioblastoma cell Human,Mouse - - - - - - CCL Tumor Progression Inhibition Brain Brain Normal Malignant - - - - Glioblastoma Glioblastoma pubmed 34239070
Pericytes augment glioblastoma cell resistance to temozolomi...
 Cell Research Xiao-Ning Zhang et al. 2021
CCL5 - CCR5 - CCL5_CCR5 Ligand-receptor Paracrine Endothelial cell Endothelial cell Malignant cell Triple Negative Breast Cancer cell Human,Mouse - - - - SERPINE1 Activation CCL Angiogenesis Inhibition Breast Breast Normal Malignant - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 28899878
Endothelial cells promote triple-negative breast cancer cell...
FASEB journal : official publication of the Federation of Am...
 Wenwen Zhang et al. 2018
CCL5 - CCR5 - CCL5_CCR5 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human,Mouse - - - - CD274 Activation CCL Tumor growth Inhibition Colon Colon Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 31802034
Macrophage-derived CCL5 facilitates immune escape of colorec...
 Cell Death & Differentiation Chao Liu et al. 2020
CCL5 - CD44 - CCL5_CD44 Ligand-receptor Paracrine Microglia Microglia Glial cell Glioma cell Human,Mouse - - - - CREB Activation CCL Tumor growth Inhibition Brain Brain Normal Malignant - - - - Glioma Glioma pubmed 32358581
Midkine activation of CD8 + T cells establishes a neuron-imm...
 Nature communications Xiaofan Guo et al. 2020
CCL7 - CCR1 - CCL7_CCR1 Ligand-receptor Autocrine Malignant cell Gastric cancer cell Malignant cell Gastric cancer cell Human,Mouse - - - - MCAM,CCL7 Activation,Activation CCR1 Migration,Invasion,Metastasis Activation,Activation,Activation Stomach Stomach Malignant Malignant - - - - Gastric Cancer Gastric Cancer pubmed 32616889
SOX18 promotes gastric cancer metastasis through transactiva...
 Oncogene Jie Chen et al. 2020
CCL7 - CCR3 - CCL7_CCR3 Ligand-receptor Paracrine Fibroblast Fibroblast Malignant cell ER+ breast cancer cell Human - - - - - - CCL Proliferation Inhibition Breast Breast Normal Malignant - - - - ER+ breast cancer ER+ breast cancer pubmed 31419632
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance...
 iScience Sumanta Chatterjee et al. 2019
CCL8 - CCR2 - CCL8_CCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Breast cancer cell Human,Mouse - - - - - - CCL Metastasis Activation,Activation Breast Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 30930117
Human Tumor-Associated Macrophage and Monocyte Transcription...
 Cancer cell Luca Cassetta et al. 2019
CCL8 - CCR2 - CCL8_CCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Endometrial cancer cell Human,Mouse - - - - - - CCL Metastasis Activation,Activation Uterus Uterus Cancer-associated Malignant - - - - Endometrial Cancer Endometrial Cancer pubmed 30930117
Human Tumor-Associated Macrophage and Monocyte Transcription...
 Cancer cell Luca Cassetta et al. 2019
CCL8 - CCR5 - CCL8_CCR5 Ligand-receptor Paracrine Endothelial cell Endothelial colony-forming cell Malignant cell Triple Negative Breast Cancer cell Human,Mouse - - - - IL8 Activation CCL Proliferation,Invasion,Migration Activation,Activation,Activation Blood Breast Normal Malignant - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 33833397
CCL8 mediates crosstalk between endothelial colony forming c...
 Oncogene Eun-Sook Kim et al. 2021
CCN4 WISP1 ITGA6 Integrin 𝛼6β1 CCN4_ITGA6 Ligand-receptor Autocrine Cancer stem cell Glioma stem cell Cancer stem cell Glioma stem cell Human - - - - - - WNT GSC proliferation,Self-renewal Activation,Activation Brain Brain Malignant Malignant - - - - Glioblastoma Glioblastoma pubmed 32541784
Dual Role of WISP1 in maintaining glioma stem cells and tumo...
 Nature communications Weiwe Tao et al. 2020
CCN4 WISP1 ITGA6 Integrin 𝛼6β1 CCN4_ITGA6 Ligand-receptor Paracrine Cancer stem cell Glioma stem cell TAM Tumor-associated Macrophage Human - - - - - - WNT M2 TAM survival,GBM growth Activation,Activation Brain Brain Malignant Cancer-associated - - - M2 Glioblastoma Glioblastoma pubmed 32541784
Dual Role of WISP1 in maintaining glioma stem cells and tumo...
 Nature communications Weiwe Tao et al. 2020
CCN4 WISP1 ITGB1 Integrin 𝛼6β1 CCN4_ITGB1 Ligand-receptor Autocrine Cancer stem cell Glioma stem cell Cancer stem cell Glioma stem cell Human - - - - - - WNT GSC proliferation,Self-renewal Activation,Activation Brain Brain Malignant Malignant - - - - Glioblastoma Glioblastoma pubmed 32541784
Dual Role of WISP1 in maintaining glioma stem cells and tumo...
 Nature communications Weiwe Tao et al. 2020
CCN4 WISP1 ITGB1 Integrin 𝛼6β1 CCN4_ITGB1 Ligand-receptor Paracrine Cancer stem cell Glioma stem cell TAM Tumor-associated Macrophage Human - - - - - - WNT M2 TAM survival,GBM growth Activation,Activation Brain Brain Malignant Cancer-associated - - - M2 Glioblastoma Glioblastoma pubmed 32541784
Dual Role of WISP1 in maintaining glioma stem cells and tumo...
 Nature communications Weiwe Tao et al. 2020
Cd200 - Cd200r - Cd200_Cd200r Ligand-receptor Juxtacrine Stem cell Mesenchymal stem cell Macrophage Proinflammatory macrophage Mouse - - - - TNFAIP6 Activation CD200 T cell Proliferation,Switching of macrophages phenotype Inhibition,Activation Uterus Uterus Normal Normal - - - M1 - - pubmed 30778166
Cell-cell contact with proinflammatory macrophages enhances ...
 Cellular & Molecular Immunology Yanhong Li et al. 2019
CD24 - SELP P-selectin CD24_SELP Ligand-receptor Juxtacrine Malignant cell Ovarian cancer cell Mesothelial cell Mesothelial cell Human,Mouse - - - - - - PI3K Metastasis Activation Ovary Peritoneum Malignant Normal - - - - High grade serous ovarian cancer (HGSOC) High grade serous ovarian cancer (HGSOC) pubmed 29739756
Alternatively-Activated Macrophages Upregulate Mesothelial E...
 Cancer research Molly J Carroll et al. 2018
CD24 - SIGLEC10 Siglec-10 CD24_SIGLEC10 Ligand-receptor Paracrine Malignant cell Breast cancer cell TAM Tumor-associated Macrophage Human,Mouse - - - - - - CD24 Tumor growth,Survival Activation,Activation Breast Breast Malignant Cancer-associated - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 31367043
CD24 signalling through macrophage Siglec-10 is a new target...
 Nature Amira A Barkal et al. 2019
CD24 - SIGLEC10 Siglec-10 CD24_SIGLEC10 Ligand-receptor Paracrine Malignant cell Ovarian cancer cell TAM Tumor-associated Macrophage Human,Mouse - - - - - - CD24 Tumor growth,Survival Activation,Activation Ovary Ovary Malignant Cancer-associated - - - - Ovarian Cancer Ovarian Cancer pubmed 31367043
CD24 signalling through macrophage Siglec-10 is a new target...
 Nature Amira A Barkal et al. 2019
CD274 PD-L1 ITGB4 - CD274_ITGB4 Ligand-receptor Juxtacrine Malignant cell Cervical cancer cell Malignant cell Cervical cancer cell Human,Mouse - - - - - - ITGB4 Tumor growth,Lymph node metastasis Activation,Activation Cervix Cervix Malignant Malignant - - - - Cervical Cancer Cervical Cancer pubmed 29706653
Programmed death ligand 1 promotes lymph node metastasis and...
 Oncogene Shaojia Wang et al. 2018
Cd274 PDL1 Pdcd1 PD1 Cd274_Pdcd1 Ligand-receptor Juxtacrine Malignant cell Triple-negative breast cancer cell T cell T cell Mouse - - - - - - PD-L1 Adaptive immunity Inhibition Breast Breast Malignant Normal - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 29367423
Chemotherapy induces enrichment of CD47+/CD73+/ PDL1+ immune...
Proceedings of the National Academy of Sciences of the Unite...
 Debangshu Samanta et al. 2018
CD274 PD-L1 PDCD1 PDCD1 CD274_PDCD1 Ligand-receptor Juxtacrine B cell B-lymphoma cell T cell CD8+ T cell Human - - - - - - PD-L1 Immune invasion Inhibition Blood Blood Malignant Normal - - - CD8+ Diffuse large B-cell lymphoma (DLBCL) Diffuse large B-cell lymphoma (DLBCL) pubmed 30925928
MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody vi...
 Molecular Cancer Zhong Zheng et al. 2019
CD274 PD-L1 PDCD1 PD-1 CD274_PDCD1 Ligand-receptor Juxtacrine B cell Antigen-presenting cell T cell T cell Human,Mouse - - - - PTPN11 Activation CD274 T cell signaling Inhibition Spleen Blood Normal Normal - - - CD8+ - - pubmed 32437509
PD-1 and BTLA regulate T cell signaling differentially and o...
 The Journal of cell biology Xiaozheng Xu et al. 2020
CD4 - MHC class II MHC class II CD4_MHC class II Receptor-receptor Juxtacrine T cell Cytotoxic CD4+ T cell Malignant cell Bladder tumor cell Human - - - - - - MHC-II Activity of cytotoxic T cell Inhibition Bladder Bladder Normal Malignant - - CD4+cytotoxic - Bladder Cancer Bladder Cancer pubmed 32497499
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in...
 Cell David Y. Oh et al. 2020
Cd80 - Ctla4 - Cd80_Ctla4 Ligand-receptor Juxtacrine Cancer stem cell Tumor-initiating stem cell T cell Cytotoxic T lymphocyte  Mouse - - - - - - CD80 tSCs survival Inhibition Skin Skin Malignant Normal - - - Cytotoxic Squamous cell carcinoma Squamous cell carcinoma pubmed 31031009
Adaptive Immune Resistance Emerges from Tumor-Initiating Ste...
 Cell Yuxuan Miao et al. 2019
CHI3L1 - IL13RA2 IL-13Rα2 CHI3L1_IL13RA2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Gastric cancer cell Human,Mouse - - - - MMP Activation MAPK Metastasis Inhibition Stomach Stomach Cancer-associated Malignant - - M2 - Gastric Cancer Gastric Cancer pubmed 28143526
Tumor-recruited M2 macrophages promote gastric and breast ca...
 Journal of Hematology & Oncology Yulei Chen et al. 2017
CHI3L1 - IL13RA2 IL-13Rα2 CHI3L1_IL13RA2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Breast cancer cell Human,Mouse - - - - MMP Activation MAPK Metastasis Inhibition Breast Breast Cancer-associated Malignant - - M2 - Breast Cancer Breast Cancer pubmed 28143526
Tumor-recruited M2 macrophages promote gastric and breast ca...
 Journal of Hematology & Oncology Yulei Chen et al. 2017
CLCF1 - CNTFR - CLCF1_CNTFR Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - CXCL6,TGFB1 Activation CLCF1 Self-renewal,Progression Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CNTF - CNTFR CNTFR_LIFR_gp130 CNTF_CNTFR Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC,MT-CO1,RPTOR Activation CNTF Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
CNTF - IL6ST CNTFR_LIFR_gp130 CNTF_IL6ST Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC,MT-CO1,RPTOR Activation CNTF Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
CNTF - LIFR CNTFR_LIFR_gp130 CNTF_LIFR Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC,MT-CO1,RPTOR Activation CNTF Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
Col1a1 Type I collagen Itga2 GPVI Col1a1_Itga2 Ligand-receptor Paracrine Malignant cell Circulating Tumor cell Platelet Platelet Mouse - - - - - - COLLAGEN Cancer cell colonization,Cancer cell extravasation Activation,Activation Breast Blood Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 32015106
Hsp47 promotes cancer metastasis by enhancing collagen-depen...
Proceedings of the National Academy of Sciences of the Unite...
 Gaofeng Xiong et al. 2020
Col1a1 Type I collagen Itgb1 Integrin α2β1 Col1a1_Itgb1 Ligand-receptor Paracrine Malignant cell Circulating Tumor cell Platelet Platelet Mouse - - - - - - COLLAGEN Cancer cell colonization,Cancer cell extravasation Activation,Activation Breast Blood Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 32015106
Hsp47 promotes cancer metastasis by enhancing collagen-depen...
Proceedings of the National Academy of Sciences of the Unite...
 Gaofeng Xiong et al. 2020
Col1a1 Type I collagen Itgb1 Integrin α2β1 Col1a1_Gp6 Ligand-receptor Paracrine Malignant cell Circulating Tumor cell Platelet Platelet Mouse - - - - - - COLLAGEN Cancer cell colonization,Cancer cell extravasation Activation,Activation Breast Blood Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 32015106
Hsp47 promotes cancer metastasis by enhancing collagen-depen...
Proceedings of the National Academy of Sciences of the Unite...
 Gaofeng Xiong et al. 2020
COMP - CD36 - COMP_CD36 Ligand-receptor Paracrine Stellate cell Hepatic stellate cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - - - COMP EMT,Proliferation,Metastasis Activation,Activation,Activation Liver Liver Normal Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30231922
HSCs-derived COMP drives hepatocellular carcinoma progressio...
 Journal of experimental & clinical cancer research Qing Li et al. 2018
Csf - Csf1r - Csf_Csf1r Ligand-receptor Paracrine Malignant cell Triple-negative breast cancer cell TAM Tumor-associated Macrophage Mouse - - - - EGF Activation CSF - - Breast Breast Malignant Cancer-associated - - - M2 Triple-negative breast cancer Triple-negative breast cancer pubmed 31911555
miR-149 Suppresses Breast Cancer Metastasis by Blocking Para...
 Cancer Research Ismael Sanchez-Gonzalez et al. 2020
CSF1 - CSF1R - CSF1_CSF1R Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse FERMT2 CSF1 Agonist - - - - CSF Tumor growth Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 28687620
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac...
 Cancer Research Khalid Sossey-Alaoui et al. 2017
CSF1 - CSF1R - CSF1_CSF1R Ligand-receptor Paracrine Malignant cell Breast cancer cell TAM Tumor-associated Macrophage Human,Mouse FERMT2 CSF1 Agonist - - - - CSF Tumor growth Inhibition Breast Breast Malignant Cancer-associated - - - M2 Breast Cancer Breast Cancer pubmed 28687620
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac...
 Cancer Research Khalid Sossey-Alaoui et al. 2017
Csf1 - Csf1r - Csf1_Csf1r Ligand-receptor Autocrine Macrophage Macrophage Macrophage Macrophage Mouse - - - - - - CSF Metastasis Inhibition Liver Liver Normal Normal - - - M1 Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30902885
Disruption of tumour-associated macrophage trafficking by th...
 Gut Ying Zhu et al. 2019
CSF1 - CSF1R - CSF1_CSF1R Ligand-receptor Paracrine TEC GBM-associated endothelial cell TAM GBM-associated macrophage Human,Mouse - - - - ARG1 Activation CSF Proliferation,Survival Activation,Activation Brain Blood Cancer-associated Cancer-associated - - - M0 Glioblastoma Glioblastoma pubmed 29422647
Vascular niche IL-6 induces alternative macrophage activatio...
 Nature communications Qirui Wang et al. 2018
CSF1 - CSF1R - CSF1_CSF1R Ligand-receptor Paracrine Stromal cell Bone marrow stromal cell TAM Supportive monocytes/macrophage Human,Mouse - - - - Cytokine,HGF Activation,Activation CSF Proliferation Inhibition Bone marrow Bone marrow Normal Cancer-associated - - - - Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) pubmed 30425048
CSF1R inhibitors exhibit antitumor activity in acute myeloid...
 Blood David K Edwards 5th et al. 2019
CSF1 - CSF1R - CSF1_CSF1R Ligand-receptor Paracrine Malignant cell Breast cancer cell TAM Tumor-associated Macrophage Human,Mouse - - - - - - CSF Proliferation of macrophage Inhibition Breast Breast Malignant Cancer-associated - - - - Breast Cancer Breast Cancer pubmed 33161320
Breast cancer cells and macrophages in a paracrine-juxtacrin...
 Biomaterials Sevgi Onal et al. 2021
Cthrc1 - Tgfbr1 - Cthrc1_Tgfbr1 Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - αSMA,DES Activation TGFb Liver fibrosis Activation Liver Liver Normal Normal - - - - Liver fibrosis Liver fibrosis pubmed 30639416
Autocrine CTHRC1 activates hepatic stellate cells and promot...
 ebiomedicine Jun Li et al. 2019
Cthrc1 - Tgfbr2 - Cthrc1_Tgfbr2 Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - αSMA,DES Activation TGFb Liver fibrosis Activation Liver Liver Normal Normal - - - - Liver fibrosis Liver fibrosis pubmed 30639416
Autocrine CTHRC1 activates hepatic stellate cells and promot...
 ebiomedicine Jun Li et al. 2019
Cthrc1 - Tgfbr3 - Cthrc1_Tgfbr3 Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - αSMA,DES Activation TGFb Liver fibrosis Activation Liver Liver Normal Normal - - - - Liver fibrosis Liver fibrosis pubmed 30639416
Autocrine CTHRC1 activates hepatic stellate cells and promot...
 ebiomedicine Jun Li et al. 2019
Cthrc1 - Wnt_noncononical_receptor - Cthrc1_Wnt_noncononical_receptor Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - - - WNT Contractility Inhibition Liver Liver Normal Normal - - - - Liver fibrosis Liver fibrosis pubmed 30639416
Autocrine CTHRC1 activates hepatic stellate cells and promot...
 ebiomedicine Jun Li et al. 2019
CTSC - PRTN3 - CTSC_PRTN3 Ligand-receptor Paracrine Malignant cell Breast cancer cell Neutrophil Neutrophil Human - - - - IL6,CCL3 Activation,Activation CTSC Metastasis Inhibition Breast Breast Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 33450198
Cathepsin C promotes breast cancer lung metastasis by modula...
 Cancer cell Yansen Xiao et al. 2021
CTSC - PRTN3 - CTSC_PRTN3 Ligand-receptor Paracrine Malignant cell Breast cancer cell Neutrophil Neutrophil Human - - - - ROS Activation CTSC Metastasis Inhibition Breast Breast Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 33450198
Cathepsin C promotes breast cancer lung metastasis by modula...
 Cancer cell Yansen Xiao et al. 2021
CTSK - TLR4 - CTSK_TLR4 Ligand-receptor Paracrine Malignant cell Colorectal cancer cell TAM Tumor-associated Macrophage Human - - - - IL10,IL17 Activation,Activation CTSK M2 polarization Inhibition Colorectum Colorectum Malignant Cancer-associated - - - - Colorectal Cancer Colorectal Cancer pubmed 30850734
Gut microbiota-stimulated cathepsin K secretion mediates TLR...
 Cell death and differentiation Rui Li et al. 2019
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Gastric cancer cell Human TNF CXCL1 Agonist - - STAT3 Activation CXCL Migration,Metastasis Activation,Activation Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 30796034
A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk betwe...
 Clinical cancer research Zhijun Zhou et al. 2019
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Autocrine Malignant cell Inflammatory breast cancer cell Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Malignant Malignant - - - - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Cancer-associated Malignant - - M2 - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Paracrine Endothelial cell Human pulmonary artery endothelial cell Malignant cell Osteosarcoma cell Human,Mouse - - - - VCAM1 Activation CXCL Migration,Metastasis Activation,Activation Lung Bone Normal Malignant - - - - Osteosarcoma Osteosarcoma pubmed 32079335
CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in...
 Cancers Chia-Chia Chao et al. 2020
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Oral squamous cell carcinoma cell Human,Mouse - - - - - - CXCL Invasion,Migration Activation,Activation Oral Oral Cancer-associated Malignant - - - - Oral squamous cell carcinoma Oral squamous cell carcinoma pubmed 30616781
Reciprocal activation of cancer-associated fibroblasts and o...
 Oral Oncology Ling-YingWei et al. 2019
CXCL1 - CXCR2 - CXCL1_CXCR2 Ligand-receptor Autocrine CAF Cancer-associated Fibroblast CAF Cancer-associated Fibroblast Human,Mouse - - - - MMP1 Activation CXCL Senescence Inhibition Oral Oral Cancer-associated Cancer-associated - - - - Oral squamous cell carcinoma Oral squamous cell carcinoma pubmed 30616781
Reciprocal activation of cancer-associated fibroblasts and o...
 Oral Oncology Ling-YingWei et al. 2019
Cxcl10 - Cxcr3 - Cxcl10_Cxcr3 Ligand-receptor Paracrine Dendritic cell CD103+ dendritic cell T cell Effector T cell Mouse - - - - - - CXCL Effector T cell recruitment Inhibition Skin Skin Malignant Normal - - CD103+ CD8+ Melanoma Melanoma pubmed 28486109
Tumor-Residing Batf3 Dendritic Cells Are Required for Effect...
 Cancer cell Stefani Spranger et al. 2017
CXCL10 - CXCR3 - CXCL10_CXCR3 Ligand-receptor Paracrine Malignant cell HPV+ CSCC cell Fibroblast Fibroblast Human,Mouse - - - - CD247 Activation CXCL Immune escape Inhibition Cervix Cervix Malignant Normal - - - - Cervical squamous cell carcinoma (CSCC) Cervical squamous cell carcinoma (CSCC) pubmed 34422627
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimul...
 Frontiers in oncology Xiaona Chen et al. 2021
Cxcl10 - Cxcr3 - Cxcl10_Cxcr3 Ligand-receptor Paracrine CAF Metastasis-associated fibroblast (MAF) Malignant cell Metastasis-initiating breast cancer cell Mouse - - - - IL1A,IL1B Activation CXCL Metastasis Inhibition Lung Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
CXCL10 - CXCR3 - CXCL10_CXCR3 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell NK cell NK cell Human,Mouse - - - - IFNG Activation CXCL Anti-tumor immunity Inhibition Liver Blood Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33689775
Interferon regulatory factor 1(IRF-1) activates anti-tumor i...
 Cancer letters Yihe Yan et al. 2021
CXCL10 - CXCR3 - CXCL10_CXCR3 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell NKT cell NKT cell Human,Mouse - - - - IFNG Activation CXCL Anti-tumor immunity Inhibition Liver Blood Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33689775
Interferon regulatory factor 1(IRF-1) activates anti-tumor i...
 Cancer letters Yihe Yan et al. 2021
CXCL10 - CXCR3 - CXCL10_CXCR3 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell T cell CD8+ T cell Human,Mouse - - - - IFNG Activation CXCL Anti-tumor immunity Inhibition Liver Blood Malignant Normal - - - CD8+ Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33689775
Interferon regulatory factor 1(IRF-1) activates anti-tumor i...
 Cancer letters Yihe Yan et al. 2021
CXCL10 - CXCR3 - CXCL10_CXCR3 Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - CXCL10 Activation CXCL Proliferation,Metastasis,Angiogenesis Activation,Activation,Activation Liver Blood Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33689775
Interferon regulatory factor 1(IRF-1) activates anti-tumor i...
 Cancer letters Yihe Yan et al. 2021
CXCL11 - CXCR3 - CXCL11_CXCR3 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - IL17 Activation CXCL Migration,Metastasis Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33707417
Cancer-associated fibroblast -derived CXCL11 modulates hepat...
 Cell death & Disease Gao Liu et al. 2021
CXCL11 - CXCR3 - CXCL11_CXCR3 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - IL1B Activation CXCL Migration,Metastasis Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33707417
Cancer-associated fibroblast -derived CXCL11 modulates hepat...
 Cell death & Disease Gao Liu et al. 2021
CXCL12 - CXCR4 - CXCL12_CXCR4 Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - - - MAPK Proliferation,Metastasis Activation,Activation Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 31534521
TCF12 promotes the tumorigenesis and metastasis of hepatocel...
 Theranostics Jing Yang et al. 2019
CXCL12 - CXCR4 - CXCL12_CXCR4 Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - - - PI3K Proliferation,Metastasis Activation,Activation Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 31534521
TCF12 promotes the tumorigenesis and metastasis of hepatocel...
 Theranostics Jing Yang et al. 2019
CXCL12 SDF-1 CXCR4 - CXCL12_CXCR4 Ligand-receptor Paracrine Stellate cell NF-κB activated pancreatic stellate cell Malignant cell Pancreatic cancer cell Human - - - - SMO Activation CXCL Metastasis Inhibition Pancreas Pancreas Normal Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 28336327
Galectin-1-driven upregulation of SDF-1 in pancreatic stella...
 Cancer letters Dong Qian et al. 2017
CXCL12 SDF-1 CXCR4 - CXCL12_CXCR4 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Non small cell lung cancer cell Human - - - - PPARD Activation CXCL12 Invasion,EMT Activation,Activation Lung Lung Cancer-associated Malignant - - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 33637678
Cancer-associated fibroblast-derived SDF-1 induces epithelia...
 Cell Death and Disease Yingyan Wang et al. 2021
CXCL12 - CXCR4 - CXCL12_CXCR4 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast TAM Tumor-associated Macrophage Human - - - - SERPINE1 Activation CXCL Proliferation,Migration,Invasion,EMT Activation,Activation,Activation,Activation Liver Liver Cancer-associated Cancer-associated - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 34195849
Cancer‑associated fibroblast‑induced M2‑polarized macrophage...
 International journal of oncology Shuhai Chen et al. 2021
CXCL13 - CXCR5 - CXCL13_CXCR5 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human - - - - MIR934 Activation CXCL Metastasis Inhibition Colon Colon Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 33213490
Tumor-derived exosomal miR-934 induces macrophage M2 polariz...
 Journal Hematology & Oncology Senlin Zhao et al. 2020
Cxcl14 - Gpr85 - Cxcl14_Gpr85 Ligand-receptor Paracrine Malignant cell HIC1-deleted breast cancer cell Fibroblast Normal-associated Fibroblast Mouse - - - - CCL17 Activation CXCL14 - - Breast Breast Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 30204129
HIC1 deletion promotes breast cancer progression by activati...
 The Journal of Clinical Investication Yingying Wang et al. 2018
CXCL16 - CXCR6 - CXCL16_CXCR6 Ligand-receptor Paracrine Dendritic cell CCR7+ dendritic cell T cell Cytotoxic T lymphocyte  Human,Mouse - - - - - - CXCL Tumor regression Inhibition - - Normal Normal - - CCR7+ DC3 Cytotoxic CD8+ Melanoma Melanoma pubmed 34343496
CXCR6 positions cytotoxic T cells to receive critical surviv...
 Cell Mauro Di Pilato et al. 2021
CXCL2 - CXCR2 - CXCL2_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Cancer-associated Malignant - - M2 - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL2 - CXCR2 - CXCL2_CXCR2 Ligand-receptor Autocrine Malignant cell Inflammatory breast cancer cell Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Malignant Malignant - - - - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL3 - CXCR2 - CXCL3_CXCR2 Ligand-receptor Paracrine Malignant cell Colon cancer cell MDSC Myeloid-derived suppressor cell Human,Mouse KRAS CXCL3 Antagonist - - - - CXCL Decreasing cytotoxic T Cell Inhibition Colon Myeloid Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30905761
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy ...
 Cancer Cell Wenting Liao et al. 2019
Cxcl3 - Cxcr2 - Cxcl3_Cxcr2 Ligand-receptor Paracrine Malignant cell Colorectal cancer cell MDSC Myeloid-derived suppressor cell Mouse - - - - - - CXCL Immune therapy resistance Inhibition Colon Colon Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30905761
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy ...
 Cancer Cell Wenting Liao et al. 2019
CXCL3 - CXCR2 - CXCL3_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Cancer-associated Malignant - - M2 - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL3 - CXCR2 - CXCL3_CXCR2 Ligand-receptor Autocrine Malignant cell Inflammatory breast cancer cell Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Malignant Malignant - - - - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Gastric cancer cell Human TNF CXCL5 Agonist - - STAT3 Activation CXCL Migration,Metastasis Activation,Activation Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 30796034
A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk betwe...
 Clinical cancer research Zhijun Zhou et al. 2019
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Autocrine Malignant cell NPC cell Malignant cell NPC cell Human,Mouse - - - - CDH1,VIM Inhibition,Activation CXCL Metastasis Inhibition Nasopharynx Nasopharynx Malignant Malignant - - - - Nasopharyngeal carcinoma (NPC) Nasopharyngeal carcinoma (NPC) pubmed 29665837
The CXCL5/CXCR2 axis contributes to the epithelial-mesenchym...
 Journal of experimental & clinical cancer research : CR Wen-Ze Qiu et al. 2018
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Autocrine Malignant cell Colorectal cancer cell Malignant cell Colorectal cancer cell Human,Mouse - - - - MMP7 Activation CXCL Invasion Inhibition Colon Colon Malignant Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 28356111
Tumor-derived CXCL5 promotes human colorectal cancer metasta...
 Molecular Cancer Jingkun Zhao et al. 2017
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Autocrine Malignant cell Colorectal cancer cell Malignant cell Colorectal cancer cell Human,Mouse - - - - SNAIL Activation CXCL EMT Inhibition Colon Colon Malignant Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 28356111
Tumor-derived CXCL5 promotes human colorectal cancer metasta...
 Molecular Cancer Jingkun Zhao et al. 2017
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Paracrine Malignant cell Colorectal cancer cell Endothelial cell Endothelial cell Human,Mouse - - - - FOXD1,VEGFA Activation CXCL Angiogenesis Inhibition Colon Colon Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30792394
CXCL5 induces tumor angiogenesis via enhancing the expressio...
 Cell Death and Disease Chun Chen et al. 2019
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Melanocyte Tumor cell Human,Mouse - - - - CD274 Activation CXCL Immune invasion Inhibition Skin Skin Cancer-associated Malignant - - - - Melanoma Melanoma pubmed 30873585
Cancer‐associated fibroblasts promote PD‐L1 expression in mi...
 International Journal of Cancer Ziqian Li et al. 2019
CXCL5 - CXCR2 - CXCL5_CXCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Tumor cell Human,Mouse - - - - CD274 Activation CXCL Immune invasion Inhibition Colon Colon Cancer-associated Malignant - - - - Colorectal Carcinoma Colorectal Carcinoma pubmed 30873585
Cancer‐associated fibroblasts promote PD‐L1 expression in mi...
 International Journal of Cancer Ziqian Li et al. 2019
CXCL6 - CNTFR - CXCL6_CNTFR Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell Neutrophil Neutrophil Human,Mouse - - - - - - - Recruitment Inhibition Liver Liver Malignant Normal - - - N1 Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CXCL6 - CXCR1 - CXCL6_CXCR1 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell CAF Cancer-associated Fibroblast Human,Mouse - - - - CLCF1 Activation CXCL Tumor growth Inhibition Liver Liver Malignant Cancer-associated - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CXCL6 - CXCR1 - CXCL6_CXCR1 Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - E2F1 Activation CXCL Self-renewal Inhibition Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CXCL6 - CXCR2 - CXCL6_CXCR2 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell CAF Cancer-associated Fibroblast Human,Mouse - - - - CLCF1 Activation CXCL Tumor growth Inhibition Liver Liver Malignant Cancer-associated - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CXCL6 - CXCR2 - CXCL6_CXCR2 Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - E2F1 Activation CXCL Self-renewal Inhibition Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33682185
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup...
 Hepatology Mengjia Song et al. 2021
CXCL8 IL-8 CXCR1 - CXCL8_CXCR1 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Fibroblast Normal ovarian fibroblast Human,Mouse - - - - - - CXCL Proliferation,Angiogenesis Activation,Activation Ovary Ovary Cancer-associated Normal - - - - Ovarian Cancer Ovarian Cancer pubmed 34277625
Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ...
 Frontiers in cell and developmental biology Zhaodong Ji et al. 2021
CXCL8 IL-8 CXCR1 - CXCL8_CXCR1 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Ovarian cancer cell Human,Mouse - - - - - - CXCL Proliferation,Stemness Activation,Activation Ovary Ovary Cancer-associated Malignant - - - - Ovarian Cancer Ovarian Cancer pubmed 34277625
Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ...
 Frontiers in cell and developmental biology Zhaodong Ji et al. 2021
CXCL8 - CXCR1 - CXCL8_CXCR1 Ligand-receptor Paracrine Fibroblast Fibroblast Malignant cell ER+ breast cancer cell Human - - - - - - IL8 Proliferation Inhibition Breast Breast Normal Malignant - - - - ER+ breast cancer ER+ breast cancer pubmed 31419632
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance...
 iScience Sumanta Chatterjee et al. 2019
CXCL8 IL-8 CXCR1 - CXCL8_CXCR1 Ligand-receptor Paracrine Stem cell Mesenchymal stem cell Malignant cell Osteosarcoma cell Human,Mouse - - - - - - CXCL Survival,Metastasis Activation,Activation Bone marrow Bone Normal Malignant - - - - Osteosarcoma Osteosarcoma pubmed 29915309
CXCR1/Akt signaling activation induced by mesenchymal stem c...
 Cell death & disease Lin Du et al. 2018
CXCL8 IL-8 CXCR1 - CXCL8_CXCR1 Ligand-receptor Autocrine Malignant cell Osteosarcoma cell Malignant cell Osteosarcoma cell Human,Mouse - - - - - - CXCL Survival,Metastasis Activation,Activation Bone Bone Malignant Malignant - - - - Osteosarcoma Osteosarcoma pubmed 29915309
CXCR1/Akt signaling activation induced by mesenchymal stem c...
 Cell death & disease Lin Du et al. 2018
CXCL8 IL8 CXCR2 - CXCL8_CXCR2 Ligand-receptor Autocrine Malignant cell Inflammatory breast cancer cell Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Malignant Malignant - - - - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL8 IL8 CXCR2 - CXCL8_CXCR2 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Inflammatory breast cancer cell Human,Mouse - - - - - - CXCL Metastasis Inhibition Breast Breast Cancer-associated Malignant - - M2 - Inflammatory breast cancer (IBC)  Inflammatory breast cancer (IBC)  pubmed 31043378
Inflammatory Breast Cancer Promotes Development of M2 Tumor-...
 Cancer research Amanda Valeta-Magara et al. 2019
CXCL8 IL-8 CXCR2 - CXCL8_CXCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Fibroblast Normal ovarian fibroblast Human,Mouse - - - - - - CXCL Proliferation,Angiogenesis Activation,Activation Ovary Ovary Cancer-associated Normal - - - - Ovarian Cancer Ovarian Cancer pubmed 34277625
Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ...
 Frontiers in cell and developmental biology Zhaodong Ji et al. 2021
CXCL8 IL-8 CXCR2 - CXCL8_CXCR2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Ovarian cancer cell Human,Mouse - - - - - - CXCL Proliferation,Stemness Activation,Activation Ovary Ovary Cancer-associated Malignant - - - - Ovarian Cancer Ovarian Cancer pubmed 34277625
Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ...
 Frontiers in cell and developmental biology Zhaodong Ji et al. 2021
CXCL8 IL-8 CXCR2 - CXCL8_CXCR2 Ligand-receptor Paracrine Malignant cell Hypoxic colorectal cancer cell Malignant cell Normoxic colorectal cancer cell Human - - - - MMP1,MMP2 Activation,Activation CXCL Metastasis Inhibition Colorectum Colorectum Malignant Malignant Hypoxic Normoxic - - Colorectal Cancer Colorectal Cancer pubmed 32737283
Hypoxic colorectal cancer cells promote metastasis of normox...
 Cell death & disease Yulong Mi et al. 2020
Cxcl9 - Cxcr3 - Cxcl9_Cxcr3 Ligand-receptor Paracrine Dendritic cell CD103+ dendritic cell T cell Effector T cell Mouse - - - - - - CXCL Effector T cell recruitment Inhibition Skin Skin Malignant Normal - - CD103+ CD8+ Melanoma Melanoma pubmed 28486109
Tumor-Residing Batf3 Dendritic Cells Are Required for Effect...
 Cancer cell Stefani Spranger et al. 2017
Cxcl9 - Cxcr3 - Cxcl9_Cxcr3 Ligand-receptor Paracrine CAF Metastasis-associated fibroblast (MAF) Malignant cell Metastasis-initiating breast cancer cell Mouse - - - - IL1A,IL1B Activation CXCL Metastasis Inhibition Lung Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
DKK1 - CKAP4 - DKK1_CKAP4 Ligand-receptor Paracrine Malignant cell Cholangiocarcinoma cell Endothelial cell Endothelial cell Human,Mouse - - - - PLVAP Activation DKK1 Angiogenesis Inhibition Liver Liver Malignant Normal - - - - Cholangiocarcinoma Cholangiocarcinoma pubmed 34079085
Plasmalemma vesicle-associated protein promotes angiogenesis...
 Oncogene Yi Wang et al. 2021
Dkk2 - Lrp6 - Dkk2_Lrp6 Ligand-receptor Autocrine Malignant cell Colorectal cancer cell Malignant cell Colorectal cancer cell Chicken,Mouse - - - - - - PI3K Aerobic glycolysis Inhibition Colon Colon Malignant Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 30867812
Tumor-secreted dickkopf2 accelerates aerobic glycolysis and ...
 Theranostics Fengliu Deng et al. 2019
Dll1 - Notch3 - Dll1_Notch3 Ligand-receptor Juxtacrine Stem cell Mammary gland stem cell Macrophage Stromal macrophage Mouse - - - - WNT10A,WNT16,WNT3 Activation,Activation,Activation NOTCH Maintain stem cell activity Inhibition Mammary gland Mammary gland Normal Normal - - - - - - pubmed 29773667
Notch ligand Dll1 mediates cross-talk between mammary stem c...
 Science Rumela Chakrabarti et al. 2018
DUSP28 - ITGA1 ITGα1 DUSP28_ITGA1 Ligand-receptor Autocrine Malignant cell Metastatic pancreatic cancer cell Malignant cell Metastatic pancreatic cancer cell Human,Mouse - - - - - - MAPK Migration,Invasion,Viability Activation,Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 30902562
Scattered DUSP28 is a novel biomarker responsible for aggrav...
 Cancer letters Jungwhoi Lee et al. 2019
Ecm1 - Itga6 - Ecm1_Itga6 Ligand-receptor Paracrine Cancer stem cell Lgr5 cell Epithelial cell Alveolar type II (AT2) cell Mouse - - - - ABCG1 Activation ECM1 Tumorigenesis Inhibition Lung Lung Malignant Normal - - - - Lung adenocarcinoma Lung adenocarcinoma pubmed 32157214
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial c...
 Oncogene Huijing Yin et al. 2020
Ecm1 - Itgb4 - Ecm1_Itgb4 Ligand-receptor Paracrine Cancer stem cell Lgr5 cell Epithelial cell Alveolar type II (AT2) cell Mouse - - - - ABCG1 Activation ECM1 Tumorigenesis Inhibition Lung Lung Malignant Normal - - - - Lung adenocarcinoma Lung adenocarcinoma pubmed 32157214
Identification of Sca-1+Abcg1+ bronchioalveolar epithelial c...
 Oncogene Huijing Yin et al. 2020
EGF - EGFR - EGF_EGFR Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Breast cancer cell Human,Mouse FERMT2 EGF Agonist - - - - EGF Tumor growth Inhibition Breast Breast Cancer-associated Malignant - - M2 - Breast Cancer Breast Cancer pubmed 28687620
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac...
 Cancer Research Khalid Sossey-Alaoui et al. 2017
EGF - EGFR - EGF_EGFR Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse FERMT2 EGF Agonist - - - - EGF Tumor growth Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 28687620
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac...
 Cancer Research Khalid Sossey-Alaoui et al. 2017
EGF - EGFR - EGF_EGFR Ligand-receptor Juxtacrine Macrophage Macrophage Malignant cell Breast cancer cell Human,Mouse - - - - - - EGF Tumor growth,Angiogenesis,Invasion,Metastasis Activation,Activation,Activation,Activation Breast Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 33161320
Breast cancer cells and macrophages in a paracrine-juxtacrin...
 Biomaterials Sevgi Onal et al. 2021
Egf - Egfr - Egf_Egfr Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Triple Negative Breast Cancer cell Mouse - - - - - - EGF Tumor progression,Metastasis Activation,Activation Breast Breast Cancer-associated Malignant - - M2 - Triple-negative breast cancer Triple-negative breast cancer pubmed 31911555
miR-149 Suppresses Breast Cancer Metastasis by Blocking Para...
 Cancer Research Ismael Sanchez-Gonzalez et al. 2020
EGF - EGFR - EGF_EGFR Ligand-receptor Autocrine Malignant cell Squamous cell carcinoma cell Malignant cell Squamous cell carcinoma cell Human - - - - - - EGF Progression Inhibition Esophagus Esophagus Malignant Malignant - - - - Squamous cell carcinoma Squamous cell carcinoma pubmed 30190462
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX...
 Nature communications Yuan Jiang et al. 2018
EGF - EGFR - EGF_EGFR Ligand-receptor Autocrine Malignant cell Squamous cell carcinoma cell Malignant cell Squamous cell carcinoma cell Human - - - - - - EGF Progression Inhibition Cervix Cervix Malignant Malignant - - - - Squamous cell carcinoma Squamous cell carcinoma pubmed 30190462
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX...
 Nature communications Yuan Jiang et al. 2018
EGF - EGFR - EGF_EGFR Ligand-receptor Autocrine Malignant cell Squamous cell carcinoma cell Malignant cell Squamous cell carcinoma cell Human - - - - - - EGF Progression Inhibition Lung Lung Malignant Malignant - - - - Squamous cell carcinoma Squamous cell carcinoma pubmed 30190462
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX...
 Nature communications Yuan Jiang et al. 2018
EGF - EGFR - EGF_EGFR Ligand-receptor Autocrine Malignant cell Squamous cell carcinoma cell Malignant cell Squamous cell carcinoma cell Human - - - - - - EGF Progression Inhibition Tongue Tongue Malignant Malignant - - - - Squamous cell carcinoma Squamous cell carcinoma pubmed 30190462
Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX...
 Nature communications Yuan Jiang et al. 2018
FAM3C ILEI LIFR - FAM3C_LIFR Ligand-receptor Autocrine Cancer stem cell Breast cancer stem cell Cancer stem cell Breast cancer stem cell Human,Mouse - - IL6ST FAM3C activation receptor - - FAM3C Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 30692635
TGFβ promotes breast cancer stem cell self-renewal through a...
 Oncogene Alec N Woosley et al. 2019
Faslg FasL Fas - Faslg_Fas Ligand-receptor Juxtacrine Macrophage CD11b+F4/80+ monocyte-derived macrophage T cell CD8+ T cell Mouse - - - - - - FASLG T cell apoptosis Inhibition Liver Liver Normal Normal - - CD11b+F4/80+ CD8+ Liver Metastasis Liver Metastasis pubmed 33398162
Liver metastasis restrains immunotherapy efficacy via macrop...
 Nature medicine Jiali Yu et al. 2021
Fasn - Cd36 - Fasn_Cd36 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Colorectal cancer cell Mouse - - - - VIM,CDH1 Activation,Inhibition LIPID Metastasis Inhibition Colon Colon Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 32327627
Reprogramming of lipid metabolism in cancer-associated fibro...
 Cell Death and Disease Jin Gong, Yiyun Lin et al. 2020
FGF18 - FGFR2 - FGF18_FGFR2 Ligand-receptor Paracrine Malignant cell Gastric cancer cell Malignant cell Gastric cancer cell Human,Mouse - - - - YAP1 Activation FGF Tumor growth Inhibition Stomach Stomach Malignant Malignant - - - - Gastric Cancer Gastric Cancer pubmed 32934314
FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 ...
 Oncogene Jinglin Zhang et al. 2020
FGF18 - FGFR3 - FGF18_FGFR3 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell Endothelial cell Endothelial cell Human,Mouse - - - - - - FGF Angiogenesis Inhibition Liver Liver Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 29242604
Ribosomal protein S15a promotes tumor angiogenesis via enhan...
 Oncogene Pengyi guo et al. 2018
FGF19 - FGF4 - FGF19_FGF4 Ligand-receptor Autocrine Malignant cell Pancreatic cancer cell Malignant cell Pancreatic cancer cell Human - - - - FGF19 Activation FGF Proliferation,Invasion Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 33066597
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr...
 Cancers Norihiko Sasaki et al. 2020
FGF19 - FGF4 - FGF19_FGF4 Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell Malignant cell Pancreatic cancer cell Human - - - - - - FGF Proliferation,Invasion Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 33066597
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr...
 Cancers Norihiko Sasaki et al. 2020
FGF19 - KLB - FGF19_KLB Ligand-receptor Autocrine Malignant cell Pancreatic cancer cell Malignant cell Pancreatic cancer cell Human - - - - FGF19 Activation FGF Proliferation,Invasion Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 33066597
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr...
 Cancers Norihiko Sasaki et al. 2020
FGF19 - KLB - FGF19_KLB Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell Malignant cell Pancreatic cancer cell Human - - - - - - FGF Proliferation,Invasion Activation,Activation Pancreas Pancreas Malignant Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 33066597
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr...
 Cancers Norihiko Sasaki et al. 2020
FGF2 - FGFR - FGF2_FGFR Ligand-receptor Paracrine Stromal cell Stromal cell Malignant cell ER+ breast cancer cell Human,Mouse - - - - RB1,BCL2L11 Activation,Activation FGFR Apoptosis,Survival Inhibition,Activation Bone marrow Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 29436393
Therapeutically targeting tumor microenvironment–mediated dr...
 Journal of Experimental Medicine Kevin Shee et al. 2018
FGF2 - FGFR - FGF2_FGFR Ligand-receptor Paracrine Malignant cell HNSCC cell CAF Cancer-associated Fibroblast Human,Mouse - - - - HGF Activation FGFR Progression Inhibition Tongue Tongue Malignant Cancer-associated - - - - Head and neck squamous cell carcinoma Head and neck squamous cell carcinoma pubmed 29769197
Cancer-associated fibroblasts drive glycolysis in a targetab...
 Cancer Research Dhruv Kumar et al. 2018
FGF2 - FGFR1 - FGF2_FGFR1 Ligand-receptor Autocrine Malignant cell Esophageal squamous cell Malignant cell Esophageal squamous cell Human - - - - - - FGF Cancer survival,Migration Activation,Activation Esophagus Esophagus Malignant Malignant - - - - Esophageal squamous cell carcinoma Esophageal squamous cell carcinoma pubmed 27317650
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microe...
 Cancer Letters Nobuhisa Takase et al. 2016
FGF2 - FGFR1 - FGF2_FGFR1 Ligand-receptor Paracrine Malignant cell Esophageal squamous cell TAM Tumor-associated Macrophage Human - - NCAM1 FGF2 activation receptor - - FGF Cancer survival,Migration Activation,Activation Esophagus Esophagus Malignant Cancer-associated - - - M2 Esophageal squamous cell carcinoma Esophageal squamous cell carcinoma pubmed 27317650
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microe...
 Cancer Letters Nobuhisa Takase et al. 2016
FGF2 - FGFR1 - FGF2_FGFR1 Ligand-receptor Paracrine CAF Tumor fibroblast T cell CD8+ T cell Human,Mouse - - - - SPRY1 Activation FGF T cell activation Inhibition Esophagus Esophagus Cancer-associated Normal - - - CD8+ Esophageal Cancer Esophageal Cancer pubmed 33093168
Tumor Fibroblast-Derived FGF2 Regulates Expression of SPRY1 ...
 Cancer Research Qing-Yun Chen et al. 2020
FGF2 - FGFR2 FGF2R FGF2_FGFR2 Ligand-receptor Paracrine Epithelial cell Keratinocyte Melanocyte Melanocyte Human - - - - MITF Activation FGF Melanogenesis Inhibition Skin Skin Normal Normal - - - - Disorders of skin pigmentation Disorders of skin pigmentation pubmed 31115052
Ganoderma lucidum polysaccharide reduces melanogenesis by in...
 Journal of cellular physiology Ling Jiang et al. 2019
FGF2 - FGFR2 FGF2R FGF2_FGFR2 Ligand-receptor Paracrine Fibroblast Fibroblast Melanocyte Melanocyte Human - - - - MITF Activation FGF Melanogenesis Inhibition Skin Skin Normal Normal - - - - Disorders of skin pigmentation Disorders of skin pigmentation pubmed 31115052
Ganoderma lucidum polysaccharide reduces melanogenesis by in...
 Journal of cellular physiology Ling Jiang et al. 2019
FGF2 FGF FGFR3 FGFR FGF2_FGFR3 Ligand-receptor Autocrine Plasma cell Plasma cell Plasma cell Plasma cell Human,Mouse - - - - MYC,GSH Inhibition,Inhibition FGF Tumor growth Inhibition,Inhibition Bone Bone Malignant Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 32094301
FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc ...
 Cancer research Roberto Ronca et al. 2020
FGF2 FGF FGFR3 FGFR FGF2_FGFR3 Ligand-receptor Paracrine Plasma cell Plasma cell Plasma cell Plasma cell Human,Mouse - - - - MYC,GSH Inhibition,Inhibition FGF Tumor growth,Apoptosis Inhibition,Inhibition Bone Bone Malignant Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 32094301
FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc ...
 Cancer research Roberto Ronca et al. 2020
FGF4 - FGFR1 - FGF4_FGFR1 Ligand-receptor Paracrine Malignant cell Lymphoma cell TEC Tumor-associated Endothelial cell Human,Mouse - - - - ETS2 Activation FGF4 Feed-forward FGFR1-ETS2 angiocrine cascade Activation Lymph Lymph Malignant Cancer-associated - - - - Lymphoma Lymphoma pubmed 27989801
Molecular Checkpoint Decisions Made by Subverted Vascular Ni...
 Cancer Cell Zhongwei Cao et al. 2017
FGL1 - LAG3 - FGL1_LAG3 Ligand-receptor Paracrine Malignant cell Tumor cell T cell T cell Human,Mouse - - - - - - FGL1 Immune invasion Inhibition Lung Blood Malignant Normal - - - - Non-small cell lung carcinomas (NSCLC) Non-small cell lung carcinomas (NSCLC) pubmed 30580966
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligan...
 Cell Jun Wang et al. 2019
FGL2 - FCGR3A CD16 FGL2_FCGR3A Ligand-receptor Paracrine Glial cell Glioma cell Macrophage Macrophage Human,Mouse - - - - PPBP Activation FCGR3A Progression Inhibition Brain Brain Malignant Normal - - - - Glioma Glioma pubmed 33676940
FGL2-wired macrophages secrete CXCL7 to regulate the stem-li...
 Cancer Letters JunYan et al. 2021
FLRT3 - LPHN - FLRT3_LPHN Ligand-receptor Autocrine Malignant cell MCF-7 breast cancer cell Malignant cell MCF-7 breast cancer cell Human - - - - LGALS9 Activation FLRT3 Cytotoxic T cell-induced death,Protect cancer cell Activation,Activation Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 31354733
The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms i...
 Frontiers in immunology Inna M Yasinska et al. 2019
GAS6 Gas6 AXL - GAS6_AXL Ligand-receptor Paracrine Stromal cell Bone marrow-derived stromal cell Cancer stem cell Leukemia stem cell Human,Mouse - - - - - - GAS Self-renewal capacity Inhibition Bone marrow Bone marrow Normal Malignant - - - - Chronic Myelogenous Leukemia (CML) Chronic Myelogenous Leukemia (CML) pubmed 27852702
Gas6/Axl Signaling regulates Self-renewal of chronic myeloge...
Clinical cancer research : an official journal of the Americ...
 Yanli Jin et al. 2017
GAS6 - AXL - GAS6_AXL Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Non small cell lung cancer cell Human,Mouse - - - - - - GAS EMT Inhibition Lung Lung Cancer-associated Malignant - - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 32909687
The actin modulator hMENA regulates GAS6-AXL axis and pro-tu...
 EMBO reports Roberta Melchionna et al. 2020
GAS6 - AXL - GAS6_AXL Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Pancreatic ductal adenocarcinoma cell Human,Mouse - - - - - - GAS EMT Inhibition Pancreas Pancreas Cancer-associated Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 32909687
The actin modulator hMENA regulates GAS6-AXL axis and pro-tu...
 EMBO reports Roberta Melchionna et al. 2020
GAS6 - MERTK - GAS6_MERTK Ligand-receptor Autocrine B cell Multiple myeloma cell B cell Multiple myeloma cell Human - - - - - - GAS6 Apoptosis,Proliferation Inhibition,Activation Blood Blood Malignant Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 28154173
Autocrine and Paracrine Interactions between Multiple Myelom...
 Journal of Biological Chemistry Miki Furukawa et al. 2017
GAS6 - MERTK - GAS6_MERTK Ligand-receptor Paracrine Stromal cell Bone marrow stromal cell B cell Multiple myeloma cell Human - - - - - - GAS6 Apoptosis,Proliferation Inhibition,Activation Bone marrow Blood Normal Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 28154173
Autocrine and Paracrine Interactions between Multiple Myelom...
 Journal of Biological Chemistry Miki Furukawa et al. 2017
GAS6 - MERTK - GAS6_MERTK Ligand-receptor Paracrine Stromal cell Bone marrow stromal cell B cell Multiple myeloma cell Human - - - - ICAM1,IL6 Activation GAS6 Proliferation,Migration,Apoptosis Activation,Activation,Inhibition Bone marrow Blood Normal Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 28154173
Autocrine and Paracrine Interactions between Multiple Myelom...
 Journal of Biological Chemistry Miki Furukawa et al. 2017
Gcg Glucagon Gcgr Glucagon receptor Gcg_Gcgr Ligand-receptor Paracrine α cell α cell β cell β cell Mouse - - - - INS Activation GCG - - Pancreas Pancreas Normal Normal - - - - - - pubmed 30380405 Insulin Secretion Depends on Intra-islet Glucagon Signaling Cell press Berit Svendsen et al. 2018
Gcg Glucagon Glp1r GLP-1R Gcg_Glp1r Ligand-receptor Paracrine α cell α cell β cell β cell Mouse - - - - INS Activation GCG - - Pancreas Pancreas Normal Normal - - - - - - pubmed 30380405 Insulin Secretion Depends on Intra-islet Glucagon Signaling Cell press Berit Svendsen et al. 2018
GDF15 - GFRAL - GDF15_GFRAL Ligand-receptor Paracrine Stellate cell Hepatic stellate cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - - - GDF15 Proliferation Inhibition Liver Liver Normal Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33346004
Hepatic Stellate Cells in hepatocellular carcinoma promote t...
 Gastroenterology Yuta Myojin et al. 2021
Gdf3 Gdf3 Acvr1c ALKs Gdf3_Acvr1c Ligand-receptor Paracrine Macrophage Adipose tissue macrophage Adipocyte Adipocyte Mouse - - - - - - GDF3 Lipolysis Inhibition Adipose Adipose Normal Normal - - - - High-fat diet-induced (HFD-induced) obesity High-fat diet-induced (HFD-induced) obesity pubmed 33830083
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3...
 JCI insight Xiangming Hu et al. 2021
GDNF - RET - GDNF_RET Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Human,Mouse - - TGFBR1 GDNF activation receptor αSMA,CoI1,GDNF Activation GDNF Fibrogenesis Inhibition Liver Liver Normal Normal - - - - Liver fibrosis Liver fibrosis pubmed 31171625
Glial cell line-derived neurotrophic factor (GDNF) mediates ...
 Gut Le Tao et al. 2019
GPI - GPER1 - GPI_GPER1 Ligand-receptor Autocrine Malignant cell Endometrium cancer cell Malignant cell Endometrium cancer cell Human - - - - - - PI3K Endometrial cancer cell growth Inhibition Endometrium Endometrium Malignant Malignant - - - - Endometrial Cancer Endometrial Cancer pubmed 30836961
Autocrine motility factor promotes endometrial cancer progre...
 Cell Communication and Signaling Yiran Li et al. 2019
HBEGF HB-EGF EGFR - HBEGF_EGFR Ligand-receptor Autocrine Malignant cell Cervical cancer cell Malignant cell Cervical cancer cell Human,Mouse - - - - - - EGF Proliferation Inhibition Cervix Cervix Malignant Malignant - - - - Cervical Cancer Cervical Cancer pubmed 28498437
Autocrine expression of the epidermal growth factor receptor...
 International Journal of Oncology Marlies Schrevel et al. 2017
HBEGF - EGFR ErbB1 HBEGF_EGFR Ligand-receptor Paracrine Endothelial cell Endothelial cell Cardiomyocyte Cardiomyocyte Human,Mouse - - - - - - EGF Cardiomyocyte growth Inhibition Heart Heart Normal Normal - - - - Cardiac Hypertrophy Cardiac Hypertrophy pubmed 30922063
Endothelial Cells Regulate Physiological Cardiomyocyte Growt...
 Circulation Riikka Kivelä et al. 2019
HGF - MET - HGF_MET Ligand-receptor Paracrine Myofibroblast Bone marrow-derived myofibroblasts (BMFs) Malignant cell Gastric cancer cell Human - - - - - - HGF - - Bone marrow Stomach Normal Malignant - - - - Gastric Cancer Gastric Cancer pubmed 27109105
Crosstalk between bone marrow-derived myofibroblasts and gas...
 Oncogene Liming Zhu et al. 2016
HGF - MET c-Met HGF_MET Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell MET-unamplified gastric cancer cell Human - - - - TWIST1 Activation HGF Metastasis Inhibition Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 30158543
HGF-mediated crosstalk between cancer-associated fibroblasts...
 Cell death & disease Xusheng Ding et al. 2018
HGF - MET - HGF_MET Ligand-receptor Paracrine Stellate cell Hepatic stellate cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - STMN1, PDGFB Activation,Activation HGF Tumor growth Inhibition Liver Liver Normal Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 31785057
STMN1 upregulation mediates hapatocellular carcinoma and hep...
 Cancer science Rui Zhang et al. 2020
HGF - MET c-MET HGF_MET Ligand-receptor Paracrine TAM AML support cell Blast AML blast Human,Mouse - - - - - - HGF Proliferation,Differentiation Activation,Activation Bone marrow Bone marrow Cancer-associated Malignant - - - - Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) pubmed 30425048
CSF1R inhibitors exhibit antitumor activity in acute myeloid...
 Blood David K Edwards 5th et al. 2019
HGF - MET c-Met HGF_MET Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell HNSCC cell Human,Mouse - - - - FGF2 Activation MET Progression Inhibition Tongue Tongue Cancer-associated Malignant - - - - Head and neck squamous cell carcinoma Head and neck squamous cell carcinoma pubmed 29769197
Cancer-associated fibroblasts drive glycolysis in a targetab...
 Cancer Research Dhruv Kumar et al. 2018
Hgf - Rnmt cMet Hgf_Rnmt Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Cancer stem cell Tumor-initiating cell Mouse - - - - HEY1 Activation HGF Tumorigenesis,Self-renewal Activation,Activation Liver Liver Cancer-associated Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 27134167
Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell...
 Cell reports Eunice Yuen Ting Lau et al. 2016
High mannose N-glycan - Mannose receptor - High mannose N-glycan_Mannose receptor Ligand-receptor Juxtacrine Cancer stem cell CD133+ hepatoma stem cell Endothelial cell Lymphatic endothelial cell Human - - - - IL17A Activation - - - Liver Lymph Malignant Normal - - CD133+ - Hepatoma Hepatoma pubmed 31499129
IL-17A secreted from lymphatic endothelial cells promotes tu...
 Journal of Hepatology Yuanyan Wei et al. 2019
HMGA1 - AGER RAGE HMGA1_AGER Ligand-receptor Autocrine Malignant cell Triple-negative breast cancer cell Malignant cell Triple Negative Breast Cancer cell Human,Mouse - - - - HMGA1 Activation HMGA1 Migration,Invasion Activation,Activation Breast Breast Malignant Malignant - - - - Triple-negative breast cancer Triple-negative breast cancer pubmed 30135148
Extracellular HMGA1 Promotes Tumor Invasion and Metastasis i...
 Clinical Cancer Research Olga Méndez et al. 2018
HMGB1 - TLR4 - HMGB1_TLR4 Ligand-receptor Paracrine Malignant cell Damaged tumour cell Myeloid cell TLR4-positive myeloid cell Human - - - - TGFB1 Activation HMGB1 Immune,Tumor growth Inhibition,Activation Breast Breast Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 34234778
High Mobility Group Box 1(HMGB1) Induces Toll-Like Receptor ...
 Frontiers in immunology Anette Teo Hansen Selnø et al. 2021
HMGB1 - TLR4 - HMGB1_TLR4 Ligand-receptor Paracrine Malignant cell Damaged tumour cell Myeloid cell TLR4-positive myeloid cell Human - - - - TGFB1 Activation HMGB1 Immune,Tumor growth Inhibition,Activation Colorectum Colorectum Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 34234778
High Mobility Group Box 1(HMGB1) Induces Toll-Like Receptor ...
 Frontiers in immunology Anette Teo Hansen Selnø et al. 2021
ICAM1 - ITGB1 - ICAM1_ITGB1 Ligand-receptor Juxtacrine Neutrophil Neutrophil Epithelial cell Cholangiocyte Human - - - - ITPR3 Inhibition ICAM Cholestasis Inhibition Liver Liver Normal Normal - - - - Alcoholic hepatitis (AH) Alcoholic hepatitis (AH) pubmed 33214166
Neutrophils interact with cholangiocytes to cause cholestati...
 Gut Masahiro Takeuchi et al. 2020
Ifn Type 1 IFN Ifnar1 - Ifn_Ifnar1 Ligand-receptor Paracrine Epithelial cell Non-tumor cell NK cell Natural killer (NK) cell  Mouse - - - - - - - NK cell anti-tumor immunity Inhibition Skin Skin Normal Normal - - - - Melanoma Melanoma pubmed 30332631
Tumor-derived cGAMP triggers a STING-mediated interferon res...
 Immunity Assaf Marcus et al. 2018
Ifng IFN-γ Ifngr1 IFN-γR Ifng_Ifngr1 Ligand-receptor Paracrine T cell CD8+ T cell Malignant cell Liver cancer cell Mouse - - - - CXCL9,CXCL10 Activation,Activation IFN-II Proliferation Inhibition Liver Liver Normal Malignant - - CD8+ - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33191170
Nanoparticle -Mediated Delivery of 2-Deoxy-D-Glucose Induces...
 Cellular and molecular gastroenterology and hepatology Kyo Sasaki et al. 2021
Ifng - Ifngr1 - Ifng_Ifngr1 Ligand-receptor Paracrine T cell T cell Stem cell Neural stem cell (NSC) Mouse - - - - BST2 Activation IFN-II Proliferation Inhibition Brain Brain Normal Normal Brain aging Brain aging CD8+ - - Brain Ageing pubmed 31270459
Single-cell analysis reveals T cell infiltration in old neur...
 Nature Ben W Dulken et al. 2019
IFNG - IFNGR1 - IFNG_IFNGR1 Ligand-receptor Paracrine T cell CD8+ T cell Malignant cell Cancer cell Human,Mouse - - - - MHC classⅠgene Activation IFN-II MHC-Ⅰantigen presentation Inhibition Lung Lung Normal Malignant - - CD8+ - Small-cell lung cancer Small-cell lung cancer pubmed 31564637
An Evolutionarily Conserved Function of Polycomb Silences th...
 Immunity Marian L. Burr et al. 2019
IFNG - IFNGR1 - IFNG_IFNGR1 Ligand-receptor Paracrine T cell T cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - CD274 Activation IFNG Proliferation Inhibition Liver Liver Normal Malignant - - CD8+ - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 31678303
Disruption of SIRT7 Increases the Efficacy of Checkpoint Inh...
 Gastroenterology Junyu Xiang et al. 2020
IGF1 - IGF1R - IGF1_IGF1R Ligand-receptor Paracrine TEC Tumor-associated endothelial cell Malignant cell Lymphoma cell Human,Mouse IGFBP7 IGF1 Antagonist - - - - IGF Chemoresistance Inhibition Lymph Lymph Cancer-associated Malignant - - - - Lymphoma Lymphoma pubmed 27989801
Molecular Checkpoint Decisions Made by Subverted Vascular Ni...
 Cancer Cell Zhongwei Cao et al. 2017
IGF2 - IGF1R - IGF2_IGF1R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell ASCC cell Human - - - - - - IGF Tumor growth Inhibition Anus Anus Cancer-associated Malignant - - - - Anal squamous cell carcinoma Anal squamous cell carcinoma pubmed 30714617
Interaction between IGF2-PI3K axis and cancer-associated-fib...
 International journal of cancer Wulfran Cacheux et al. 2019
IGF2 - IGF1R IGF-1R IGF2_IGF1R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Lung cancer cell Human,Mouse - - - - ABCB1 Activation IGF Drug resistance Inhibition Lung Lung Cancer-associated Malignant - - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 29383798
Reverse of non-small cell lung cancer drug resistance induce...
 Cancer Science Quanhui Zhang et al. 2018
IGFBP2 - ITGA5 - IGFBP2_ITGA5 Ligand-receptor Paracrine Glial cell Glioma cell Glial cell Glioma cell Human,Mouse - - - - MMP2,CDH5 Activation FAK/ERK Vasculogenic mimicry formation Inhibition Brain Brain Malignant Malignant - - - - Glioma Glioma pubmed 30368528
IGFBP2 promotes vasculogenic mimicry formation via regulatin...
 Oncogene Y Liu et al. 2019
IGFBP2 - ITGB1 - IGFBP2_ITGB1 Ligand-receptor Paracrine Glial cell Glioma cell Glial cell Glioma cell Human,Mouse - - - - MMP2,CDH5 Activation FAK/ERK Vasculogenic mimicry formation Inhibition Brain Brain Malignant Malignant - - - - Glioma Glioma pubmed 30368528
IGFBP2 promotes vasculogenic mimicry formation via regulatin...
 Oncogene Y Liu et al. 2019
IGSF11 VSIG-3 VSIR VISTA IGSF11_VSIR Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell T cell T cell Human,Mouse - - - - - - VISTA T cell production,Cytokine production Inhibition,Activation Liver Blood Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30220083 VSIG-3 as a ligand of VISTA inhibits human T-cell function Immunology Jinghua Wang et al. 2019
IGSF11 VSIG-3 VSIR VISTA IGSF11_VSIR Ligand-receptor Paracrine Malignant cell Gastric cancer cell T cell T cell Human,Mouse - - - - - - VISTA T cell production,Cytokine production Inhibition,Activation Stomach Blood Malignant Normal - - - - Intestinal-type gastric cancer Intestinal-type gastric cancer pubmed 30220083 VSIG-3 as a ligand of VISTA inhibits human T-cell function Immunology Jinghua Wang et al. 2019
IL10 - IL10RA - IL10_IL10RA Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human - - - - - - IL10 Invasion,Metastasis Activation,Activation Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 30850734
Gut microbiota-stimulated cathepsin K secretion mediates TLR...
 Cell death and differentiation Rui Li et al. 2019
IL11 - IL11R - IL11_IL11R Ligand-receptor Paracrine Malignant cell Prostate cancer cell Preosteoclast Preosteoclast Human,Mouse - - - - - - IL11 Osteoclastogenesis Activation Prostate Bone Malignant Normal - - - - Prostate Cancer Prostate Cancer pubmed 33731701
Acetylation of KLF5 maintains EMT and tumorigenicity to caus...
 Nature communications Baotong Zhang et al. 2021
Il11 - Il11ra - Il11_Il11ra Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - CXCL1,WNT4,CCL11 Activation,Activation,Activation IL11 - - Liver Liver Normal Normal - - - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 31398325
Landscape of Intercellular Crosstalk in Healthy and NASH Liv...
 Molecular cell Xuelian Xiong et al. 2019
Il11 - Il11ra gp130+IL11RA Il11_Il11ra Ligand-receptor Autocrine Hepatocyte Hepatocyte Hepatocyte Hepatocyte Mouse - - - - IL11 Activation IL6 Cell death Inhibition Liver Liver Normal Normal Lipotoxic Lipotoxic - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
Il11 - Il11ra gp130+IL11RA Il11_Il11ra Ligand-receptor Paracrine Hepatocyte Hepatocyte Stellate cell Hepatic stellate cell Mouse - - - - IL11 Activation IL6 - - Liver Liver Normal Normal Lipotoxic - - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
Il11 - Il11ra gp130+IL11RA Il11_Il11ra Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - - - IL6 Fibrosis Inhibition Liver Liver Normal Normal - - - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
Il11 - Il6st gp130+IL11RA Il11_Il6st Ligand-receptor Autocrine Hepatocyte Hepatocyte Hepatocyte Hepatocyte Mouse - - - - IL11 Activation IL6 Cell death Inhibition Liver Liver Normal Normal Lipotoxic Lipotoxic - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
Il11 - Il6st gp130+IL11RA Il11_Il6st Ligand-receptor Paracrine Hepatocyte Hepatocyte Stellate cell Hepatic stellate cell Mouse - - - - IL11 Activation IL6 - - Liver Liver Normal Normal Lipotoxic - - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
Il11 - Il6st gp130+IL11RA Il11_Il6st Ligand-receptor Autocrine Stellate cell Hepatic stellate cell Stellate cell Hepatic stellate cell Mouse - - - - - - IL6 Fibrosis Inhibition Liver Liver Normal Normal - - - - Non-alcoholic steatohepatitis (NASH) Non-alcoholic steatohepatitis (NASH) pubmed 33397952
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a...
 Nature communications Feng Yang et al. 2020
IL13 - IL13RA1 - IL13_IL13RA1 Ligand-receptor Paracrine Epithelial cell Pancreatic intraepithelial neoplasia (PanIN) cell Macrophage Inflammatory macrophage Human,Mouse - - - - - - IL4 Activated macrophages(M2) Inhibition Pancreas Pancreas Normal Normal - - - M1 Pancreatic Cancer Pancreatic Cancer pubmed 28514653
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio...
 Cell reports Geou-YarhLiou et al. 2017
IL13 - IL13RA1 - IL13_IL13RA1 Ligand-receptor Paracrine TUFT cell TUFT cell Macrophage Inflammatory macrophage Human,Mouse - - - - - - IL4 Activated macrophages(M2) Inhibition Pancreas Pancreas Malignant Normal - - - M1 Pancreatic Cancer Pancreatic Cancer pubmed 28514653
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio...
 Cell reports Geou-YarhLiou et al. 2017
IL13 - IL13RA1 IL2rγ-IL13r⍺1 IL13_IL13RA1 Ligand-receptor Paracrine T cell CD4+ Th2 cell Malignant cell Pancreatic ductal adenocarcinoma cell Human,Mouse - - - - MYC Activation IL4 Tumorigenesis,Proliferation,Tumor growth Activation,Activation,Activation Pancreas Pancreas Normal Malignant - - CD4+ TH2 - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 32046984
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ...
 Cancer Discovery Prasenjit Dey et al. 2020
IL13 - IL2RG IL2rγ-IL13r⍺1 IL13_IL2RG Ligand-receptor Paracrine T cell CD4+ Th2 cell Malignant cell Pancreatic ductal adenocarcinoma cell Human,Mouse - - - - MYC Activation IL4 Tumorigenesis,Proliferation,Tumor growth Activation,Activation,Activation Pancreas Pancreas Normal Malignant - - CD4+ TH2 - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 32046984
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ...
 Cancer Discovery Prasenjit Dey et al. 2020
IL15 - IL2RB IL-2Rβ IL15_IL2RB Ligand-receptor Paracrine Dendritic cell CCR7+ dendritic cell T cell Cytotoxic T lymphocyte  Human,Mouse - - - - - - IL15 Tumor regression Inhibition - - Normal Normal - - CCR7+ DC3 Cytotoxic CD8+ Melanoma Melanoma pubmed 34343496
CXCR6 positions cytotoxic T cells to receive critical surviv...
 Cell Mauro Di Pilato et al. 2021
IL15RA IL-15Rα IL2RG IL-2Rγ IL15RA_IL2RG Ligand-receptor Paracrine Dendritic cell CCR7+ dendritic cell T cell Cytotoxic T lymphocyte  Human,Mouse - - - - - - IL15RA Tumor regression Inhibition - - Normal Normal - - CCR7+ DC3 Cytotoxic CD8+ Melanoma Melanoma pubmed 34343496
CXCR6 positions cytotoxic T cells to receive critical surviv...
 Cell Mauro Di Pilato et al. 2021
IL17A - IL17RA - IL17A_IL17RA Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human - - - - - - IL17 Invasion,Metastasis Activation,Activation Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 30850734
Gut microbiota-stimulated cathepsin K secretion mediates TLR...
 Cell death and differentiation Rui Li et al. 2019
IL17A - IL17RA - IL17A_IL17RA Ligand-receptor Paracrine Endothelial cell Lymphatic endothelial cell Cancer stem cell CD133+ hepatoma stem cell Human - - - - CD274 Activation IL17A Immune invasion,Self-renewal Activation,Activation Lymph Liver Normal Malignant - - - CD133+ Hepatoma Hepatoma pubmed 31499129
IL-17A secreted from lymphatic endothelial cells promotes tu...
 Journal of Hepatology Yuanyan Wei et al. 2019
IL18 - IL18R - IL18_IL18R Ligand-receptor Paracrine TAM Myeloma-associated macrophage Plasma cell Multiple myeloma cell Human,Mouse - - - - - - IL18 Bone destruction,Proliferation of MM cell Activation,Activation Bone marrow Bone marrow Cancer-associated Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 34289378
β2-microglobulin triggers NLRP3 inflammasome activation in t...
 Immunity Daniel Hofbauer et al. 2021
Il1a - Il1r1 - Il1a_Il1r1 Ligand-receptor Paracrine Malignant cell Metastasis-initiating breast cancer cell CAF Metastasis-associated fibroblast (MAF) Mouse - - - - CXCL9,CXCL10 Activation IL1 - - Breast Lung Malignant Cancer-associated - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
Il1a - Il1r1 - Il1a_Il1r1 Ligand-receptor Paracrine Keratinocyte Epidermal keratinocyte Fibroblast Dermal fibroblast Mouse Il1rn Il1a antagonist - - Cox2 Activation IL1 Myofibroblast differentiation Inhibition Skin Skin Normal Normal - - - - - - pubmed 30878678
Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Ef...
 Journal of Investigative Dermatology Rui Zheng et al. 2019
IL1A - IL1R1 - IL1A_IL1R1 Ligand-receptor Autocrine Stellate cell Pancreatic stellate cell Stellate cell Hepatic stellate cell Human,Mouse - - - - LIF Activation IL1 Generate inflammatory CAF Inhibition Pancreas Pancreas Normal Normal - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 30366930
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Sha...
 Cancer Discovery Giulia Biffi et al. 2019
Il1a - Il1r1 - Il1a_Il1r1 Ligand-receptor Autocrine Malignant cell Metastasis-initiating breast cancer cell Malignant cell Metastasis-initiating breast cancer cell Mouse - - - - IL1A,IL1B Activation IL1 Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
IL1B - IL18R - IL1B_IL18R Ligand-receptor Paracrine TAM Myeloma-associated macrophage Plasma cell Multiple myeloma cell Human,Mouse - - - - - - IL1 Bone destruction,Proliferation of MM cell Activation,Activation Bone marrow Bone marrow Cancer-associated Malignant - - - - Multiple Myeloma Multiple Myeloma pubmed 34289378
β2-microglobulin triggers NLRP3 inflammasome activation in t...
 Immunity Daniel Hofbauer et al. 2021
Il1b - Il1r1 - Il1b_Il1r1 Ligand-receptor Paracrine Malignant cell Metastasis-initiating breast cancer cell CAF Metastasis-associated fibroblast (MAF) Mouse - - - - CXCL9,CXCL10 Activation IL1 - - Breast Lung Malignant Cancer-associated - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
IL1B - IL1R1 - IL1B_IL1R1 Ligand-receptor Paracrine Fibroblast Fibroblast Malignant cell ER+ breast cancer cell Human - - - - - - IL1 Proliferation Inhibition Breast Breast Normal Malignant - - - - ER+ breast cancer ER+ breast cancer pubmed 31419632
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance...
 iScience Sumanta Chatterjee et al. 2019
IL1B - IL1R1 - IL1B_IL1R1 Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell Schwann cell Schwann cell Human,Mouse - - - - IL6 Activation IL1 - - Pancreas Pancreas Malignant Normal - - - - Pancreatic Cancer Pancreatic Cancer pubmed 32308766
Tumor-neuroglia interaction promotes pancreatic cancer metas...
 Theranostics Dan Su et al. 2020
Il1b - Il1r1 - Il1b_Il1r1 Ligand-receptor Autocrine Malignant cell Metastasis-initiating breast cancer cell Malignant cell Metastasis-initiating breast cancer cell Mouse - - - - IL1A,IL1B Activation IL1 Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 32198421
Metastasis-initiating cells induce and exploit a fibroblast ...
 Nature communications Maren Pein et al. 2020
IL1B IL-1β IL1R1 IL-1R IL1B_IL1R1 Ligand-receptor Paracrine Malignant cell Oral squamous cell carcinoma cell CAF Cancer-associated Fibroblast Human,Mouse - - - - CXCL1,MMP1 Activation,Activation IL1B Invasion,Migration Activation,Activation Oral Oral Malignant Cancer-associated - - - - Oral squamous cell carcinoma Oral squamous cell carcinoma pubmed 30616781
Reciprocal activation of cancer-associated fibroblasts and o...
 Oral Oncology Ling-YingWei et al. 2019
IL1RN - IL1R1 IL-1R IL1RN_IL1R1 Ligand-receptor Paracrine Macrophage Alternatively activated macrophage Epithelial cell Pancreatic intraepithelial neoplasia (PanIN) cell Human,Mouse - - - - - - - Pancreatic fibrogenesis,Tumorigenesis Activation,Activation Pancreas Pancreas Normal Normal - - M2 - Pancreatic Cancer Pancreatic Cancer pubmed 28514653
The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio...
 Cell reports Geou-YarhLiou et al. 2017
IL32 - ITGB3 Integrin β3 IL32_ITGB3 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Breast cancer cell Human,Mouse - - - - FN1,CDH2,VIM Activation,Activation,Activation IL32 EMT,Invasion,Metastasis Activation,Activation,Activation Breast Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 30391782
Cancer-associated fibroblast(CAF)-derived IL32 promotes brea...
 Cancer letters Siyang Wen et al. 2019
IL33 - IL1RAP - IL33_IL1RAP Ligand-receptor Paracrine Perivascular cell Perivascular cell TAM Tumor-associated Macrophage Human,Mouse - - - - - - IL1 Invasion,Metastasis Activation,Activation Blood Pancreas Normal Cancer-associated - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
IL33 - IL1RAP - IL33_IL1RAP Ligand-receptor Paracrine Fibroblast Stromal fibroblast TAM Tumor-associated Macrophage Human,Mouse - - - - - - IL1 Invasion,Metastasis Activation,Activation Pancreas Pancreas Normal Cancer-associated - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
IL33 - IL1RL1 - IL33_IL1RL1 Ligand-receptor Paracrine Perivascular cell Perivascular cell TAM Tumor-associated Macrophage Human,Mouse - - - - - - IL1 Invasion,Metastasis Activation,Activation Blood Pancreas Normal Cancer-associated - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
IL33 - IL1RL1 - IL33_IL1RL1 Ligand-receptor Paracrine Fibroblast Stromal fibroblast TAM Tumor-associated Macrophage Human,Mouse - - - - - - IL1 Invasion,Metastasis Activation,Activation Pancreas Pancreas Normal Cancer-associated - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
Il33 - Il1rl1 - Il33_Il1rl1 Ligand-receptor Paracrine Cancer stem cell Tumor-initiating cell TAM Tumor-associated Macrophage Mouse - - - - TGFB1 Activation IL33 Differentiation Inhibition Skin Skin Malignant Cancer-associated - - - FcεRIα+ Squamous cell carcinoma Squamous cell carcinoma pubmed 32675345
Tumor-initiating cells establish an IL-33-TGF-β niche signal...
 Science Sachiko Taniguchi et al. 2020
IL33 IL-33 IL1RL1 ST2L IL33_IL1RL1 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Gastric cancer cell Human,Mouse - - - - - - IL33 EMT,Migration,Invasion,Metastasis Activation,Activation,Activation,Activation Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 31659258
The reciprocal interaction between tumor cells and activated...
 Oncogene Quan Zhou et al. 2020
IL37 - IL37R - IL37_IL37R Ligand-receptor Paracrine Malignant cell Non small cell lung cancer cell TAM Tumor-conditioned macrophage Human - - - - MARCO Activation IL37 Immune suppressive phenotype Inhibition Lung Lung Malignant Cancer-associated - - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 33293426
Targeting MARCO and IL37R on Immunosuppressive Macrophages i...
 Cancer Research Linnéa La Fleur et al. 2021
IL4 - IL2RG IL2rγ-IL4r⍺ IL4_IL2RG Ligand-receptor Paracrine T cell CD4+ Th2 cell Malignant cell Pancreatic ductal adenocarcinoma cell Human,Mouse - - - - MYC Activation IL2 Tumorigenesis,Proliferation,Tumor growth Activation,Activation,Activation Pancreas Pancreas Normal Malignant - - CD4+ TH2 - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 32046984
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ...
 Cancer Discovery Prasenjit Dey et al. 2020
IL4 - IL4R - IL4_IL4R Ligand-receptor Autocrine B cell Chronic lymphocytic leukemia cell B cell Chronic lymphocytic leukemia cell Human - - - - JAG1,NOTCH1,NOTCH2 Activation,Activation,Activation IL4 Tumor growth Inhibition Bone marrow Bone marrow Malignant Malignant - - - - Chronic lymphocytic leukemia (CLL) Chronic lymphocytic leukemia (CLL) pubmed 30478302
IL-4-dependent Jagged1 expression/processing is associated w...
 Cell death & disease Filomena De Falco et al. 2018
IL4 - IL4R - IL4_IL4R Ligand-receptor Paracrine Stem cell Adipose-derived stem cell Malignant cell Breast cancer cell Human,Mouse - - - - DUSP4 Inhibition IL4 Proliferation,Invasion,Stemness Activation,Activation,Activation Adipose Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 28400477
IL4 Primes the Dynamics of Breast Cancer Progression via DUS...
 Cancer Research Miriam Gaggianesi et al. 2017
IL4 - IL4R - IL4_IL4R Ligand-receptor Paracrine T cell CD4+ helper T cell Malignant cell Breast cancer cell Human,Mouse - - - - DUSP4 Inhibition IL4 Proliferation,Invasion,Stemness Activation,Activation,Activation Breast Breast Normal Malignant - - CD4+ - Breast Cancer Breast Cancer pubmed 28400477
IL4 Primes the Dynamics of Breast Cancer Progression via DUS...
 Cancer Research Miriam Gaggianesi et al. 2017
IL4 - IL4R IL2rγ-IL4r⍺ IL4_IL4R Ligand-receptor Paracrine T cell CD4+ Th2 cell Malignant cell Pancreatic ductal adenocarcinoma cell Human,Mouse - - - - MYC Activation IL2 Tumorigenesis,Proliferation,Tumor growth Activation,Activation,Activation Pancreas Pancreas Normal Malignant - - CD4+ TH2 - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 32046984
Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ...
 Cancer Discovery Prasenjit Dey et al. 2020
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Myofibroblast Bone marrow-derived myofibroblasts (BMFs) Myofibroblast Bone marrow-derived myofibroblasts (BMFs) Human - - - - - - IL6 CSC-like cell Inhibition Bone marrow Bone marrow Normal Normal - - - - Gastric Cancer Gastric Cancer pubmed 27109105
Crosstalk between bone marrow-derived myofibroblasts and gas...
 Oncogene Liming Zhu et al. 2016
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Cancer stem cell Glioma stem cell Cancer stem cell Glioma stem cell Human - - - - STAT3 Activation - GSC characteristic Inhibition Brain Brain Malignant Malignant - - - - Glioma Glioma pubmed 33576874
Regulatory T cells promote glioma cell stemness through TGF-...
 Cancer Immunology, Immunotherapy Shasha Liu et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Stem cell Mesenchymal stem cell Malignant cell Osteosarcoma cell Human,Mouse - - - - - - STAT3 Tumor growth,Metastasis Activation,Activation Bone Bone Normal Malignant - - - - Osteosarcoma Osteosarcoma pubmed 28053020
Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosa...
 Clinical cancer research S. Rubina Baglio et al. 2017
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - AKR1C3 Activation IL6 Proliferation,Metastasis Activation,Activation Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 33361392
A Positive Feedback Loop of AKR1C3-Mediated Activation of NF...
 Cancer Research Qingqing Zhou et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Glial cell Tumor cell Glial cell Tumor cell Human,Mouse - - - - - - IL6 Tumor Progression Inhibition Brain Brain Malignant Malignant - - - - Glioblastoma Glioblastoma pubmed 28724615
Glioblastoma cellular cross-talk converges on NF-kB to atten...
 Genes & development Ciro Zanca et al. 2017
IL6 IL-6 IL6R IL-6R IL6_IL6R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Gastric cancer cell Human,Mouse - - - - - - IL6 Tumor growth,Invasion Activation,Activation Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 30927911
Targeting interleukin-6 as a strategy to overcome stroma-ind...
 Molecular cancer In Hye Ham et al. 2019
IL6 IL-6 IL6R IL-6R IL6_IL6R Ligand-receptor Paracrine CAF CD146-positive vascular cancer-associated fibroblast Malignant cell Intrahepatic cholangiocarcinoma cell Human - - - - EZH2 Activation IL6 Stemness,Proliferation,Malignancy Activation,Activation,Activation Bile duct Bile duct Cancer-associated Malignant - - CD146+ - Intrahepatic cholangiocarcinoma (ICC)  Intrahepatic cholangiocarcinoma (ICC)  pubmed 32505533
Single-cell transcriptomic architecture and intercellular cr...
 Journal of hepatology Min Zhang et al. 2020
IL6 - IL6R IL-6R IL6_IL6R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell MET-unamplified gastric cancer cell Human - - - - TWIST1 Activation IL6 Metastasis Inhibition Stomach Stomach Cancer-associated Malignant - - - - Gastric Cancer Gastric Cancer pubmed 30158543
HGF-mediated crosstalk between cancer-associated fibroblasts...
 Cell death & disease Xusheng Ding et al. 2018
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Pancreatic cancer cell Human,Mouse - - - - miR-124 Inhibition IL6 Invasion Inhibition Pancreas Pancreas Cancer-associated Malignant - - M2 - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 33172931
A Notch-Dependent Inflammatory Feedback Circuit between Macr...
 Cancer research Yawen Geng et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Granulocyte Granulocyte Malignant cell Colorectal cancer cell Human,Mouse - - - - - - IL6 Autophagy,Chemotherapy resistance Activation,Activation Colorectum Colorectum Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 34131122
IL-6 regulates autophagy and chemotherapy resistance by prom...
 Nature communications Fuqing Hu et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human,Mouse - - - - - - IL6 Autophagy,Chemotherapy resistance Activation,Activation Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 34131122
IL-6 regulates autophagy and chemotherapy resistance by prom...
 Nature communications Fuqing Hu et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Fibroblast Fibroblast Malignant cell Colorectal cancer cell Human,Mouse - - - - - - IL6 Autophagy,Chemotherapy resistance Activation,Activation Colorectum Colorectum Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 34131122
IL-6 regulates autophagy and chemotherapy resistance by prom...
 Nature communications Fuqing Hu et al. 2021
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Malignant cell Colorectal tumor cell CAF Cancer-associated Fibroblast Human,Mouse - - - - POSTN Activation IL6 - - Colorectum Colorectum Malignant Cancer-associated - - - - Colorectal Cancer Colorectal Cancer pubmed 31968254
Periostin Promotes Colorectal Tumorigenesis through Integrin...
 Cell reports Handong Ma et al. 2020
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine TEC GBM-associated endothelial cell TAM GBM-associated macrophage Human,Mouse - - - - ARG1 Activation IL6 Proliferation,Survival Activation,Activation Brain Blood Cancer-associated Cancer-associated - - - M0 Glioblastoma Glioblastoma pubmed 29422647
Vascular niche IL-6 induces alternative macrophage activatio...
 Nature communications Qirui Wang et al. 2018
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colorectal cancer cell Human,Mouse - - - - FOXQ1,CCL2 Activation,Activation IL6 Migration,Invasion,Metastasis Activation,Activation,Activation Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 30927925
Crosstalk between cancer cells and tumor associated macropha...
 Molecular cancer Chen Wei et al. 2019
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse RTRAF IL6 Agonist - - - - IL6 CSC,Metastasis Activation,Activation Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 28166202
CGI-99 promotes breast cancer metastasis via autocrine inter...
 Oncogene C Lin et al. 2017
IL6 - IL6R IL-6R_GP130 IL6_IL6R Ligand-receptor Paracrine B cell B cell Malignant cell Lung cancer cell Human,Mouse - - - - MUC16 Activation IL6 EMT,Metastasis Activation,Activation Lung Lung Normal Malignant - - - - Lung Cancer Lung Cancer pubmed 33056994
ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expre...
 Cell death & disease Yuanyuan Lei et al. 2020
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Ovarian cancer cell Human,Mouse - - - - MMP9,NANOG,SOX9 Activation,Activation,Activation IL6 Migration,Invasion,Metastasis,Stemness Activation,Activation,Activation,Activation Ovary Ovary Cancer-associated Malignant - - - - Ovarian Cancer Ovarian Cancer pubmed 31212816
Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasi...
 Cancers Michelle K Y Siu et al. 2019
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Schwann cell Schwann cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - IL6 EMT,Metastasis Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 32308766
Tumor-neuroglia interaction promotes pancreatic cancer metas...
 Theranostics Dan Su et al. 2020
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Malignant cell HPV+ cervical cancer cell Malignant cell HPV positive cervical cancer cell Human - - - - STAT3 Activation IL6 Proliferation,Survival Activation,Activation Cervix Cervix Malignant Malignant - - - - HPV positive cervical cancer HPV positive cervical cancer pubmed 31226168
Autocrine STAT3 activation in HPV positive cervical cancer t...
 PLoS pathogens Ethan L. Morgan et al. 2019
IL6 - IL6R - IL6_IL6R Ligand-receptor Autocrine Malignant cell Hepatocellular carcinoma cell Malignant cell Hepatocellular carcinoma cell Human,Mouse - - - - SREBP1,EIF4EBP1 Activation,Inhibition IL6 Flammation,Tumorigenesis Activation,Activation Liver Liver Malignant Malignant - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30523261
An inflammatory-CCRK circuitry drives mTORC1-dependent metab...
 Nature communications Hanyong Sun et al. 2018
IL6 - IL6R - IL6_IL6R Ligand-receptor Paracrine Macrophage Macrophage Malignant cell Gastric cancer cell Human,Mouse - - - - NEK9 Activation IL6 Metastasis Inhibition Stomach Stomach Normal Malignant - - - - Gastric Cancer Gastric Cancer pubmed 33500736
NEK9, a novel effector of IL-6/STAT3, regulates metastasis o...
 Theranostics Guofang Lu et al. 2021
IL6 - IL6R IL-6R IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Cancer cell Human,Mouse - - - - - - - Migration,Invasion,Metastasis Activation,Activation,Activation Lung Lung Cancer-associated Malignant - - - - Lung Cancer Lung Cancer pubmed 31735641
Cancer-Derived Succinate Promotes Macrophage Polarization an...
 Molecular Cell Jing Yiing Wu et al. 2020
IL6 IL-6 IL6R GP130/IL-6R IL6_IL6R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Prostate cancer cell Human - - - - - - IL6 Tumorigenesis,Stemness,Invasion Activation,Activation,Activation Prostate Prostate Cancer-associated Malignant - - - - Prostate Cancer Prostate Cancer pubmed 32066880
MAOA-mediated reprogramming of stromal fibroblasts promotes ...
 Oncogene Jingjing Li et al. 2020
IL6 IL-6 IL6R IL-6R IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Tumor cell Human - - - - CD274 Activation IL6 Invasion Inhibition Thyroid Thyroid Cancer-associated Malignant - - - - Thyroid Cancer Thyroid Cancer pubmed 33247999
Interleukin 6 regulates the expression of programmed cell de...
 Cancer Sci Guo-Qiang Zhang et al. 2021
IL6 IL-6 IL6R IL-6Rα IL6_IL6R Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Tumor cell Human,Mouse - - - - IL6 Activation IL6 Proliferation,Apoptosis,Invasion,Tumor growth Activation,Inhibition,Activation,Activation Esophagus Esophagus Cancer-associated Malignant - - - - Esophageal squamous cell carcinoma Esophageal squamous cell carcinoma pubmed 29976575
IL-6 Mediates Cross-Talk between Tumor Cells and Activated F...
 Cancer research Tatiana A Karakasheva et al. 2018
IL6 IL-6 IL6R IL-6Rα IL6_IL6R Ligand-receptor Autocrine CAF Cancer-associated Fibroblast CAF Cancer-associated Fibroblast Human,Mouse - - - - - - IL6 Proliferation,Apoptosis,Invasion,Tumor growth Activation,Inhibition,Activation,Activation Esophagus Esophagus Cancer-associated Cancer-associated - - - - Esophageal Cancer Esophageal Cancer pubmed 29976575
IL-6 Mediates Cross-Talk between Tumor Cells and Activated F...
 Cancer research Tatiana A Karakasheva et al. 2018
IL6 IL-6 IL6R GP130/IL-6R IL6_IL6R Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colon cancer cell Human - - - - - - IL6 EMT,Migration,Invasion Activation,Activation,Activation Colon Colon Cancer-associated Malignant - - CD68+ - Colon Cancer Colon Cancer pubmed 30243096
PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through ...
 Biomedicine& Pharmacotherapy Sikang Gao et al. 2018
Il6 Obesity-induced interleukin-6 Il6ra - Il6_Il6ra Ligand-receptor Paracrine B cell B cell TAM Tumor-associated Macrophage Mouse - - - - CCL20 Activation - CAC progression Inhibition Stomach Stomach Normal Cancer-associated - - - M2 Colitis-associated colorectal cancer (CAC)  Colitis-associated colorectal cancer (CAC)  pubmed 29695802
Obesity exacerbates colitis-associated cancer via IL-6-regul...
 Nature communications Claudia M Wunderlich et al. 2018
Il6 IL-6 Il6ra IL-6 receptor Il6_Il6ra Ligand-receptor Paracrine Macrophage Hepatic macrophage Hepatocyte Hepatocyte Mouse - - - - FOXM1 Activation IL6 Proliferation Inhibition Liver Liver Normal Normal - - - - - - pubmed 30546054
Vagus-macrophage-hepatocyte link promotes post-injury liver ...
 Nature Communications Tomohito Izumi et al. 2018
IL6 - IL6ST - IL6_IL6ST Ligand-receptor Autocrine Glial cell Tumor cell Glial cell Tumor cell Human,Mouse - - - - - - IL6 Tumor Progression Inhibition Brain Brain Malignant Malignant - - - - Glioblastoma Glioblastoma pubmed 28724615
Glioblastoma cellular cross-talk converges on NF-kB to atten...
 Genes & development Ciro Zanca et al. 2017
IL6 - IL6ST IL-6R_GP130 IL6_IL6ST Ligand-receptor Paracrine B cell B cell Malignant cell Lung cancer cell Human,Mouse - - - - MUC16 Activation IL6 EMT,Metastasis Activation,Activation Lung Lung Normal Malignant - - - - Lung Cancer Lung Cancer pubmed 33056994
ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expre...
 Cell death & disease Yuanyuan Lei et al. 2020
IL6 - IL6ST GP130 IL6_IL6ST Ligand-receptor Paracrine Fibroblast Fibroblast Malignant cell ER+ breast cancer cell Human - - - - - - IL6 Proliferation Inhibition Breast Breast Normal Malignant - - - - ER+ breast cancer ER+ breast cancer pubmed 31419632
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance...
 iScience Sumanta Chatterjee et al. 2019
IL6 - IL6ST - IL6_IL6ST Ligand-receptor Paracrine Schwann cell Schwann cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - IL6 EMT,Metastasis Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic Cancer Pancreatic Cancer pubmed 32308766
Tumor-neuroglia interaction promotes pancreatic cancer metas...
 Theranostics Dan Su et al. 2020
IL6 - IL6ST - IL6_IL6ST Ligand-receptor Autocrine Malignant cell HPV+ cervical cancer cell Malignant cell HPV positive cervical cancer cell Human - - - - STAT3 Activation IL6 Proliferation,Survival Activation,Activation Cervix Cervix Malignant Malignant - - - - HPV positive cervical cancer HPV positive cervical cancer pubmed 31226168
Autocrine STAT3 activation in HPV positive cervical cancer t...
 PLoS pathogens Ethan L. Morgan et al. 2019
IL6 - IL6ST - IL6_IL6ST Ligand-receptor Paracrine Macrophage Macrophage Malignant cell Gastric cancer cell Human,Mouse - - - - NEK9 Activation IL6 Metastasis Inhibition Stomach Stomach Normal Malignant - - - - Gastric Cancer Gastric Cancer pubmed 33500736
NEK9, a novel effector of IL-6/STAT3, regulates metastasis o...
 Theranostics Guofang Lu et al. 2021
IL6 IL-6 IL6ST GP130/IL-6R IL6_IL6ST Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Prostate cancer cell Human - - - - - - IL6 Tumorigenesis,Stemness,Invasion Activation,Activation,Activation Prostate Prostate Cancer-associated Malignant - - - - Prostate Cancer Prostate Cancer pubmed 32066880
MAOA-mediated reprogramming of stromal fibroblasts promotes ...
 Oncogene Jingjing Li et al. 2020
IL6 IL-6 IL6ST GP130/IL-6R IL6_IL6ST Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colon cancer cell Human - - - - - - IL6 EMT,Migration,Invasion Activation,Activation,Activation Colon Colon Cancer-associated Malignant - - CD68+ - Colon Cancer Colon Cancer pubmed 30243096
PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through ...
 Biomedicine& Pharmacotherapy Sikang Gao et al. 2018
Il7 IL-7 Il7r IL-7R Il7_Il7r Ligand-receptor Paracrine Stromal cell Bone marrow stromal cell B cell Pro B cell Mouse - - - - - - IL7 - - Bone marrow Bone marrow Normal Normal - - - Pro - - pubmed 30158115
Cell circuits between B cell progenitors and IL-7+ mesenchym...
 Journal of Experimental Medicine Chris Fistonich et al. 2018
INHBA Activin A ACVR1B ActRIB INHBA_ACVR1B Ligand-receptor Paracrine Malignant cell Cancer cell Fibroblast Fibroblast Human,Mouse - - - - DIAPH3 Activation ACTIVIN Proliferation,Migration Activation,Activation Skin Skin Malignant Normal - - - - Skin Cancer Skin Cancer pubmed 32150356
A paracrine activin A–mDia2 axis promotes squamous carcinoge...
 EMBO Molecular Medicine Michael Cangkrama et al. 2020
JAG1 Jagged1 NOTCH1 - JAG1_NOTCH1 Ligand-receptor Juxtacrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - - - NOTCH Proliferation,Metastasis Activation,Activation Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 32943090
Linc00514 promotes breast cancer metastasis and M2 polarizat...
 Journal of experimental & clinical cancer research : CR Sifeng Tao et al. 2020
JAG1 Jagged1 NOTCH1 Notch1 JAG1_NOTCH1 Ligand-receptor Juxtacrine Endothelial cell Endothelial cell Malignant cell Breast cancer cell Human,Mouse - - - - VEGFA Activation NOTCH Angiogenesis Inhibition Breast Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 33046710
Jagged1-Notch1-deployed tumor perivascular niche promotes br...
 Nature communications Huimin Jiang et al. 2020
Lactate - Gpr132 - Lactate_Gpr132 Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell TAM Tumor-associated Macrophage Mouse - - - - VEGF Activation - M2 polarization Inhibition Liver Liver Malignant Cancer-associated - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 30180849
NFE2L2 activation drive macrophages polarization and cancer ...
 Cell Communication and Signaling Rui Feng et al. 2018
Lactate - Gpr132 - Lactate_Gpr132 Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell TAM Tumor-associated Macrophage Mouse - - - - VEGF Activation - M2 polarization Inhibition Pancreas Pancreas Malignant Cancer-associated - - - - Pancreatic Cancer Pancreatic Cancer pubmed 30180849
NFE2L2 activation drive macrophages polarization and cancer ...
 Cell Communication and Signaling Rui Feng et al. 2018
Lactate - Mct - Lactate_Mct Ligand-receptor Paracrine Malignant cell Colorectal cancer cell Endothelial cell Endothelial cell Chicken,Mouse - - - - - - - Angiogenesis Inhibition Colon Colon Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30867812
Tumor-secreted dickkopf2 accelerates aerobic glycolysis and ...
 Theranostics Fengliu Deng et al. 2019
LCN2 - SLC22A17 LCN2R LCN2_SLC22A17 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Endothelial cell Lymphatic endothelial cell Human - - - - VEGFC Activation LCN2 - - Breast Lymph Cancer-associated Normal - - - - Breast Cancer Breast Cancer pubmed 27353364
Lipocalin 2 from macrophages stimulated by tumor cell-derive...
 Science signaling Michaela Jung et al. 2016
LEP Leptin LEPR Ob-R LEP_LEPR Ligand-receptor Paracrine Adipocyte - Malignant cell Breast cancer cell Human - - - - ACAT2 Activation PI3K Proliferation,Migration,Invasion Activation,Activation,Activation Breast Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 28770546
Leptin promotes the migration and invasion of breast cancer ...
 Cellular Oncology Yunxiu Huang et al. 2017
Lgals3 Galectin 3 Gp6 Glycoprotein VI Lgals3_Gp6 Ligand-receptor Juxtacrine Malignant cell Colorectal cancer cell Platelet Platelet Mouse - - - - EGF,PDGF,TGFB1 Activation,Activation,Activation GALECTIN - - Colon Blood Malignant Normal - - - - Colorectal Cancer Colorectal Cancer pubmed 30305116
Role of platelets and platelet receptors in cancer metastasi...
 Journal of hematology & oncology Martin Schlesinger et al. 2018
Lgals3 Galectin-3 Gp6 GPVI Lgals3_Gp6 Ligand-receptor Juxtacrine Malignant cell Breast cancer cell Platelet Platelet Mouse - - - - - - GALECTIN Metastasis Inhibition Breast Breast Malignant Normal - - - - Breast Cancer Breast Cancer pubmed 32040544
Platelet glycoprotein VI promotes metastasis through interac...
 Blood Elmina Mammadova-Bach et al. 2020
LGALS9 Galactin-9 VSIR VISTA LGALS9_VSIR Ligand-receptor Paracrine Monocyte Acute myeloid leukemia cell T cell T cell Human - - - - GZMB Activation GALECTIN Apoptosis Inhibition Blood Blood Malignant Normal - - - - Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) pubmed 33329552
Ligand-Receptor Interactions of Galectin-9 and VISTA Suppres...
 Frontiers in Immunology Inna M. Yasinska et al. 2020
LGALS9 Galactin-9 VSIR VISTA LGALS9_VSIR Ligand-receptor Paracrine Monocyte Acute myeloid leukemia cell T cell T cell Human - - - - GZMB Activation GALECTIN Apoptosis Inhibition Bone marrow Blood Malignant Normal - - - - Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) pubmed 33329552
Ligand-Receptor Interactions of Galectin-9 and VISTA Suppres...
 Frontiers in Immunology Inna M. Yasinska et al. 2020
LIF - IL6ST - LIF_IL6ST Ligand-receptor Paracrine Stellate cell Pancreatic stellate cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - LIFR Tumor progression,Metastasis Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 30996350
Targeting LIF-mediated paracrine interaction for pancreatic ...
 Nature Yu Shi et al. 2019
LIF - IL6ST LIFR_gp130 LIF_IL6ST Ligand-receptor Paracrine Stromal cell Stromal cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation LIFR Metastasis Inhibition Bone marrow Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
LIF - LIFR - LIF_LIFR Ligand-receptor Paracrine Stellate cell Pancreatic stellate cell Malignant cell Pancreatic cancer cell Human,Mouse - - - - - - LIFR Tumor progression,Metastasis Activation,Activation Pancreas Pancreas Normal Malignant - - - - Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma pubmed 30996350
Targeting LIF-mediated paracrine interaction for pancreatic ...
 Nature Yu Shi et al. 2019
LIF - LIFR LIFR_gp130 LIF_LIFR Ligand-receptor Paracrine Stromal cell Stromal cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation LIFR Metastasis Inhibition Bone marrow Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
LILRB2 - HLA-B HLA-B LILRB2_HLA-B Ligand-receptor Paracrine Malignant cell Lung adenocarcinoma cell T cell T cell Human - - - - - - - Myeloid cell activation Inhibition Lung Lung Malignant Normal - - - - Lung adenocarcinoma Lung adenocarcinoma pubmed 32549766
Ligand-receptor interaction atlas within and between tumor c...
 International Journal of Biological Sciences Zhencong Chen et al. 2020
Lipid - Cd36 - Lipid_Cd36 Ligand-receptor Paracrine Adipocyte Adipocyte Malignant cell Breast cancer cell Mouse - - - - CD36,FABP4 Activation,Activation CD36 Proliferation Inhibition Breast Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 33087562
Blocking PPARγ interaction facilitates Nur77 interdiction of...
Proceedings of the National Academy of Sciences of the Unite...
 Peng-Bo Yang et al. 2020
Lipid - Fabp4 - Lipid_Fabp4 Ligand-receptor Paracrine Adipocyte Adipocyte Malignant cell Breast cancer cell Mouse - - - - CD36,FABP4 Activation,Activation FABP4 Proliferation Inhibition Breast Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 33087562
Blocking PPARγ interaction facilitates Nur77 interdiction of...
Proceedings of the National Academy of Sciences of the Unite...
 Peng-Bo Yang et al. 2020
LOX - ITGB1 β1 integrin LOX_ITGB1 Ligand-receptor Paracrine Glial cell PTEN-deficient glioblastoma cell Monocyte Blood-derived monocyte Human,Mouse BAPN LOX Antagonist - - SPP1 Activation LOX Survival,Angiogenesis Activation,Activation Brain Blood vessel Malignant Normal PTEN-deficient - - - Glioblastoma Glioblastoma pubmed 31185211
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthet...
 Cancer cell Peiwen Chen et al. 2019
LPA - LPAR - LPA_LPAR Ligand-receptor Paracrine Malignant cell Ovarian cancer cell CAF Cancer-associated Fibroblast Human - - - - αSMA Activation LPA - - Ascites Ascites Malignant Cancer-associated - - - - Ovarian Cancer Ovarian Cancer pubmed 30503552
Ovarian Cancer Cell-derived Lysophosphatidic Acid Induces Gl...
 Cancer Letters Rangasudhagar Radhakrishnan et al. 2019
LRP6N LRP6 ectodomain CXCR4 SDF-1 LRP6N_CXCR4 Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - - - LRP6N Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 31010839
LRP6 Ectodomain Prevents SDF-1/CXCR4-Induced Breast Cancer M...
Clinical cancer research : an official journal of the Americ...
 Jiankang Zhang et al. 2019
LTA Lymphotoxin-α TNFRSF14 - LTA_TNFRSF14 Ligand-receptor Autocrine Lymphocyte Hodgkin/Reed-Sternberg cell Lymphocyte Hodgkin/Reed-Sternberg cell Human - - - - CD274,PDCD1LG2 Activation,Activation Lta Immune invasion Inhibition Blood Blood Malignant Malignant - - - - Hodgkin lymphoma Hodgkin lymphoma pubmed 30696620
Autocrine LTA signaling drives NF-κB and JAK-STAT activity a...
 Blood Linda von Hoff et al. 2019
Lta1 LTα1β2 Ltbr LTβR Lta1_Ltbr Ligand-receptor Paracrine B cell Eμ-Myc B-cell Endothelial cell Blood endothelial cell Mouse - - - - - - LT Angiogenesis Inhibition Blood Blood Malignant Normal - - - - Lymphoma Lymphoma pubmed 31932457
Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signal...
 Cancer Research Marleen Gloger et al. 2020
LTD4 - CYSLTR1 CysLTR1 LTD4_CYSLTR1 Ligand-receptor Paracrine TAM Tumor-associated Macrophage Malignant cell Colon cancer cell Human,Mouse - - - - MMP9 Activation LTD4 Invasion Inhibition Colon Colon Cancer-associated Malignant - - M2 - Colorectal Cancer Colorectal Cancer pubmed 28098359
M2-like macrophages induce colon cancer cell invasion via ma...
 Journal of cellular physiology Katyayni Vinnakota et al. 2017
MBTPS1 - S1PR1 - MBTPS1_S1PR1 Ligand-receptor Paracrine Malignant cell Apoptotic tumor cell TAM Tumor-associated Macrophage Human - - - - LCN2 Activation S1P - - Breast Breast Malignant Cancer-associated - - - - Breast Cancer Breast Cancer pubmed 27353364
Lipocalin 2 from macrophages stimulated by tumor cell-derive...
 Science signaling Michaela Jung et al. 2016
MDK Midkine LRP1 - MDK_LRP1 Ligand-receptor Paracrine Neuron Nf1-mutant Retinal ganglion cell T cell CD8+ T cell Human,Mouse - - - - CCL4 Activation MK - - Brain Brain Normal Normal - - - CD8+ Glioma Glioma pubmed 32358581
Midkine activation of CD8 + T cells establishes a neuron-imm...
 Nature communications Xiaofan Guo et al. 2020
Mdk Midkine Notch2 - Mdk_Notch2 Ligand-receptor Autocrine Malignant cell Non small cell lung cancer cell Malignant cell Non small cell lung cancer cell Mouse - - - - - - NOTCH2 Tumor progression,Metastasis,Angiogenesis Activation,Activation,Inhibition Lung Lung Malignant Malignant Hypoxic - - - Non-small cell lung cancer Non-small cell lung cancer pubmed 32847073
Midkine Is a Potential Therapeutic Target of Tumorigenesis, ...
 Cancers Dong Hoon Shin et al. 2020
NELL2 - ROBO3 - NELL2_ROBO3 Ligand-receptor Autocrine Malignant cell Ewing sarcoma cell Malignant cell Ewing sarcoma cell Human,Mouse - - - - BAF complex Activation NELL2 Tumor growth Inhibition Bone Bone Malignant Malignant - - - - Ewing Sarcoma Ewing Sarcoma pubmed 34233189
NELL2-cdc42 signaling regulates BAF complexes and Ewing sarc...
 Cell Reports Panneerselvam Jayabal et al. 2021
NGF - NTRK1 TrkA NGF_NTRK1 Ligand-receptor Paracrine Neuron Neuron Malignant cell Head and neck squamous cell carcinoma cell Human - - - - SNAI2,TWIST1 Activation,Activation NT EMT Inhibition Head and neck Head and neck Normal Malignant - - - - Head and neck squamous cell carcinoma Head and neck squamous cell carcinoma pubmed 31838083
Nerve growth factor (NGF)-TrkA axis in head and neck squamou...
 Cancer letters Chengzhong Lin et al. 2020
NRG1 - ERBB2 - NRG1_ERBB2 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Prostate cancer cell Human,Mouse - - - - - Activation PI3K Tumor survival,Proliferation Activation,Activation Prostate Prostate Cancer-associated Malignant - - - - Prostate Cancer Prostate Cancer pubmed 32679108
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Re...
 Cancer cell Zeda Zhang et al. 2020
NRG1 - ERBB3 - NRG1_ERBB3 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Prostate cancer cell Human,Mouse - - - - - Activation PI3K Tumor survival,Proliferation Activation,Activation Prostate Prostate Cancer-associated Malignant - - - - Prostate Cancer Prostate Cancer pubmed 32679108
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Re...
 Cancer cell Zeda Zhang et al. 2020
NRG1 - ERBB3 HER3 NRG1_ERBB3 Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Luminal breast cancer cell Human - - - - - - NRG1 Proliferation,Migration Activation,Activation Breast Breast Cancer-associated Malignant - - - - Breast Cancer Breast Cancer pubmed 33692466
Stromal NRG1 in luminal breast cancer defines pro-fibrotic a...
 Oncogene Mireia Berdiel-Acer et al. 2021
NRG1 - ERBB3 ErbB3 NRG1_ERBB3 Ligand-receptor Paracrine Malignant cell Breast cancer cell TAM Tumor-associated Macrophage Human,Mouse - - - - JAG1 Activation NRG Invasion,Intravasation Activation,Activation Breast Breast Malignant Cancer-associated - - - - Breast Cancer Breast Cancer pubmed 29636067
A novel neuregulin - jagged1 paracrine loop in breast cancer...
 Breast Cancer Research Ramon M. Cabrera et al. 2018
NRG1 - ERBB4 ErbB4 NRG1_ERBB4 Ligand-receptor Paracrine Endothelial cell Endothelial cell Cardiomyocyte Cardiomyocyte Human,Mouse - - - - - - NRG Cardiomyocyte growth Inhibition Heart Heart Normal Normal - - - - Cardiac Hypertrophy Cardiac Hypertrophy pubmed 30922063
Endothelial Cells Regulate Physiological Cardiomyocyte Growt...
 Circulation Riikka Kivelä et al. 2019
OSM - IL6ST OSMR_gp130 OSM_IL6ST Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation OSM Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
OSM - IL6ST LIFR_gp130 OSM_IL6ST Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation OSM Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
OSM - LIFR LIFR_gp130 OSM_LIFR Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation OSM Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
OSM - OSMR OSMR_gp130 OSM_OSMR Ligand-receptor Autocrine Malignant cell Breast cancer cell Malignant cell Breast cancer cell Human,Mouse - - - - SRC Activation OSM Metastasis Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 34477239
gp130 Cytokines Activate Novel Signaling Pathways and Alter ...
 Journal of Bone and Mineral Research Tolu Omokehinde et al. 2021
Pdgf - Pdgfr - Pdgf_Pdgfr Ligand-receptor Paracrine Platelet Platelet Malignant cell Colorectal cancer cell Mouse - - - - PGE2 Activation PDGF - - Blood Colon Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 30305116
Role of platelets and platelet receptors in cancer metastasi...
 Journal of hematology & oncology Martin Schlesinger et al. 2018
PDGFB PDGF-BB PDGFRB PDGFRβ PDGFB_PDGFRB Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell Perivascular cell Perivascular cell Human,Mouse - - - - IL33 Activation PDGF Metastasis Activation Pancreas Blood Malignant Normal - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
PDGFB PDGF-BB PDGFRB PDGFRβ PDGFB_PDGFRB Ligand-receptor Paracrine Malignant cell Pancreatic cancer cell Fibroblast Stromal fibroblast Human,Mouse - - - - IL33 Activation PDGF Metastasis Inhibition Pancreas Pancreas Malignant Normal - - - - Pancreatic Cancer Pancreatic Cancer pubmed 27150562
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom...
 Nature Communications Yunlong Yang et al. 2016
PDGFB PDGF-BB PDGFRB PDGFR-β PDGFB_PDGFRB Ligand-receptor Paracrine Cancer stem cell Carcinoma associated mesenchymal stem/stromal cell Cancer stem cell Cancer stem-like cell Human,Mouse - - - - - - PDGF Stemness,Platinum resistance,EMT Activation,Activation,Activation Ovary Ovary Malignant Malignant - - - - Ovarian Cancer Ovarian Cancer pubmed 32726910
Carcinoma-Associated Mesenchymal Stem Cells Promote Chemores...
 Cancers Shreya Raghavan et al. 2020
PDGFB - PDGFRB - PDGFB_PDGFRB Ligand-receptor Paracrine Malignant cell Hepatocellular carcinoma cell Stellate cell Hepatic stellate cell Human,Mouse - - - - HGF Activation PDGF HSC activation Inhibition Liver Liver Malignant Normal - - - - Hepatocellular carcinoma Hepatocellular carcinoma pubmed 31785057
STMN1 upregulation mediates hapatocellular carcinoma and hep...
 Cancer science Rui Zhang et al. 2020
PDGFB - PDGFRB - PDGFB_PDGFRB Ligand-receptor Autocrine Malignant cell Anoikis resistant cancer cell Malignant cell Anoikis resistant cancer cell Human,Mouse - - - - PDGFB Activation PDGF Angiogenesis,Metastasis Activation,Activation Stomach Stomach Malignant Malignant - - - - Gastric Cancer Gastric Cancer pubmed 34341514
Anoikis resistant gastric cancer cells promote angiogenesis ...
 Oncogene Shangce Du et al. 2021
PDGFB - PDGFRB - PDGFB_PDGFRB Ligand-receptor Paracrine Malignant cell Anoikis resistant gastric cancer cell Endothelial cell Vascular endothelial cell Human,Mouse - - - - - - PDGF Angiogenesis,Metastasis Activation,Activation Stomach Stomach Malignant Normal - - - - Gastric Cancer Gastric Cancer pubmed 34341514
Anoikis resistant gastric cancer cells promote angiogenesis ...
 Oncogene Shangce Du et al. 2021
PDGF-BB - PDGFRB - PDGF-BB_PDGFRB Ligand-receptor Paracrine Malignant cell ER+ breast cancer cell Fibroblast Fibroblast Human - - - - IL1B Activation PDGF-BB - - Breast Breast Malignant Normal - - - - ER+ breast cancer ER+ breast cancer pubmed 31419632
Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance...
 iScience Sumanta Chatterjee et al. 2019
PDGFC - PDGFRA - PDGFC_PDGFRA Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Gastrointestinal stromal tumor cell Human - - - - SLUG Activation PI3K Proliferation,Migration,Invasion Activation,Activation,Activation Stomach Stomach Cancer-associated Malignant - - - - Gastrointestinal Stromal Tumors (GIST) Gastrointestinal Stromal Tumors (GIST) pubmed 33603171
Cancer-associated fibroblast secretion of PDGFC promotes gas...
 Oncogene Hyunho Yoon et al. 2021
PDGFD - PDGFRB - PDGFD_PDGFRB Ligand-receptor Paracrine Malignant cell Cholangiocarcinoma cell CAF Cancer-associated Fibroblast Human - - - - VEGFC,VEGFA Activation,Activation PDGF Lymphatic vasculature expansion,Tumor cell intravasation Activation,Activation Liver Liver Malignant Cancer-associated - - - - Cholangiocarcinoma Cholangiocarcinoma pubmed 30553841
Platelet-derived growth factor-D enables liver myofibroblast...
 Journal of hepatology Massimiliano Cadamuro et al. 2019
PGE2 - EGFR - PGE2_EGFR Ligand-receptor Paracrine Glial cell Tumor-activated enteric glial cell Cancer stem cell Colon cancer stem cell Human,Mouse - - - - - - PGE2 Tumor growth Inhibition Colon Colon Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 31662289
Tumor cells hijack enteric glia to activate colon cancer ste...
 EBioMedicine Simon Valès et al. 2019
Pge2 - Nr4a1 Nur77 Pge2_Nr4a1 Ligand-receptor Paracrine Malignant cell Prostate cancer cell Stromal cell Stromal cell Mouse - - - - PRL Activation PGE2 - - Prostate Prostate Malignant Normal - - - - Prostate Cancer Prostate Cancer pubmed 30819896
Cox-2 mediates tumor-stromal prolactin signaling to initiate...
Proceedings of the National Academy of Sciences of the Unite...
 Yu Zheng et al. 2019
PGE2 - PTGER4 EP4 PGE2_PTGER4 Ligand-receptor Paracrine Glial cell Tumor-activated enteric glial cell Cancer stem cell Colon cancer stem cell Human,Mouse - - - - - - PGE2 Tumorigenesis,Tumor growth Activation,Activation Colon Colon Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 31662289
Tumor cells hijack enteric glia to activate colon cancer ste...
 EBioMedicine Simon Valès et al. 2019
PGE2 - PTGER4 - PGE2_PTGER4 Ligand-receptor Paracrine Stellate cell Hepatic stellate cell T cell CD8+ T cell Human,Mouse - - - - - - - Anti-tumor immunity Inhibition Liver Liver Normal Normal - - - CD8+ Obesity-Associated Liver Cancer Obesity-Associated Liver Cancer pubmed 28202625
Gut Microbiota Promotes Obesity-Associated Liver Cancer thro...
 Cancer Discovery Tze Mun Loo et al. 2017
PGE2 - PTGER4 - PGE2_PTGER4 Ligand-receptor Paracrine Stellate cell Hepatic stellate cell T cell CD8+ T cell Human,Mouse - - - - - - - Anti-tumor immunity Inhibition Liver Liver Normal Normal - - - CD8+ Obesity-Associated Liver Cancer Obesity-Associated Liver Cancer pubmed 28202625
Gut Microbiota Promotes Obesity-Associated Liver Cancer thro...
 Cancer Discovery Tze Mun Loo et al. 2017
PGE2 - PTGER4 Ptger4 PGE2_PTGER4 Ligand-receptor Paracrine Fibroblast Ptgs2-expressing fibroblast Cancer stem cell Tumour-initiating stem cell Human,Mouse - - - - - - PGE2 Tumorigenesis Inhibition Colon Colon Normal Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 32322056
Paracrine orchestration of intestinal tumorigenesis by a mes...
 Nature Manolis Roulis et al. 2020
PGE2 - PTGER5 EP4 PGE2_PTGER5 Ligand-receptor Autocrine Malignant cell Tumor cell Malignant cell Tumor cell Human - - - - VEGFA,VEGFC,VEGFD Activation,Activation,Activation PGE2 Proliferation Inhibition Breast Breast Malignant Malignant - - - - Breast Cancer Breast Cancer pubmed 31277414
Mir526b and Mir655 promote Tumor Associated Angiogenesis and...
 Cansers Stephanie Hunter et al. 2019
PGF PIGE FLT1 VEGFR1 PGF_FLT1 Ligand-receptor Paracrine Cardiomyocyte Cardiomyocyte Endothelial cell Endothelial cell Human,Mouse - - - - - - VEGF Cardiomyocyte growth - Heart Heart Normal Normal - - - - Cardiac Hypertrophy Cardiac Hypertrophy pubmed 30922063
Endothelial Cells Regulate Physiological Cardiomyocyte Growt...
 Circulation Riikka Kivelä et al. 2019
Plau uPA Plaur uPAR Plau_Plaur Ligand-receptor Autocrine Malignant cell Keratinocyte Malignant cell Keratinocyte Mouse - - - - - - PLAU Basal cell carcinoma formation Inhibition Skin Skin Malignant Malignant - - - - Basal cell carcinoma Basal cell carcinoma pubmed 30291846
Overexpression of Desmoglein 2 in a Mouse model of Gorlin Sy...
 The Journal of investigative dermatology Donna M Brennan-Crispi et al. 2019
Polyunsaturated fatty acid - Pparg PPARγ Polyunsaturated fatty acid_Pparg Ligand-receptor Paracrine Astrocyte Astrocyte Malignant cell Brain metastatic cancer cell Mouse - - - - - - PPARG Brain metastasis Inhibition Brain Breast Normal Malignant - - - - Breast Cancer Breast Cancer pubmed 31578185
Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ S...
 Cancer Discovery Yongkang Zou et al. 2019
POSTN Periostin ITGAV - POSTN_ITGAV Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Colorectal cancer cell Human,Mouse - - - - IL6 Activation PERIOSTIN Tumorigenesis Inhibition Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 31968254
Periostin Promotes Colorectal Tumorigenesis through Integrin...
 Cell reports Handong Ma et al. 2020
POSTN Periostin ITGAV - POSTN_ITGAV Ligand-receptor Paracrine CAF Cancer-associated Fibroblast Malignant cell Colorectal cancer cell Human,Mouse - - - - IL6 Activation PERIOSTIN Tumorigenesis Inhibition Colorectum Colorectum Cancer-associated Malignant - - - - Colorectal Cancer Colorectal Cancer pubmed 31968254
Periostin Promotes Colorectal Tumorigenesis through Integrin...
 Cell reports Handong Ma et al. 2020
POSTN Periostin ITGAV Integrin αvβ3 POSTN_ITGAV Ligand-receptor Paracrine Stromal cell Bone marrow-derived mesenchymal stromal cell Lymphocyte B cell acute lymphoblastic leukemia cell Human,Mouse - - - - CCL2 Activation Postn Proliferation,Progression Activation,Activation Bone marrow Blood Normal Malignant - - - - B cell acute lymphoblastic leukemia B cell acute lymphoblastic leukemia pubmed 30726736
Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo...
 Cell Reports Zhenling Ma et al. 2019
POSTN Periostin ITGAV Integrin αvβ5 POSTN_ITGAV Ligand-receptor Paracrine Stromal cell Bone marrow-derived mesenchymal stromal cell Lymphocyte B cell acute lymphoblastic leukemia cell Human,Mouse - -