Search cell-cell interactions
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A total of 520 cell-cell interactions
| Source gene | Source gene alias | Target gene | Target gene alias | Interaction name | Interaction type | Signaling type | Source cell | Literature source cell | Target cell | Literature target cell | Species | Source gene cofactor | Source gene cofactor function | Target gene cofactor | Target gene cofactor function | Effector | Effector function | Pathway name | Phenotype | Mode of Action | Source tissue | Target tissue | Source cell pathology | Target cell pathology | Source cell perturbation | Target cell perturbation | Source cell stage | Target cell stage | Patient Pathology | Literature patient Pathology | DB Source | PMID | Journal title | Journal name | Authors | Publication year |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Acetylcholine | - | Musacarinic receptor | - | Acetylcholine_Musacarinic receptor | Ligand-receptor | Paracrine | Neuron | Vagal nerve | Macrophage | Hepatic macrophage | Mouse | - | - | - | - | - | - | Musacarinic | - | - | Brain | Liver | Normal | Normal | - | - | - | - | - | - | pubmed | 30546054 | Vagus-macrophage-hepatocyte link promotes post-injury liver ... |
Nature Communications | Tomohito Izumi et al. | 2018 |
| ANG | - | EGFR | - | ANG_EGFR | Ligand-receptor | Paracrine | Endothelial cell | Endothelial cell | TEC | Tumor-associated Endothelial cell | Human,Mouse | - | - | - | - | ANG | Activation | EGFR | Migration,Invasion,Tumor initiation,Tumor development | Activation,Activation,Activation,Activation | Pancreas | Pancreas | Normal | Cancer-associated | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 29606349 | Angiogenin/ribonuclease 5 is an EGFR ligand and a serum biom... |
Cancer Cell | Ying-Nai Wang et al. | 2018 |
| ANG | - | EGFR | - | ANG_EGFR | Ligand-receptor | Autocrine | TEC | Tumor-associated endothelial cell | TEC | Tumor-associated Endothelial cell | Human,Mouse | - | - | - | - | ANG | Activation | EGFR | Migration,Invasion,Tumor initiation,Tumor development | Activation,Activation,Activation,Activation | Pancreas | Pancreas | Cancer-associated | Cancer-associated | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 29606349 | Angiogenin/ribonuclease 5 is an EGFR ligand and a serum biom... |
Cancer Cell | Ying-Nai Wang et al. | 2018 |
| ANGPT1 | - | TEK | Tie2 | ANGPT1_TEK | Ligand-receptor | Autocrine | Glial cell | Glioblastoma cell | Glial cell | Glioblastoma cell | Human,Mouse | - | - | - | - | ANGPT1 | Activation | ANGPT | Survival,Proliferation | Activation,Activation | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 31763674 | ΔNp73/ETS2 complex drives glioblastoma pathogenesis— targeti... |
Neuro-Oncology | Maren Cam et al. | 2020 |
| ANGPT1 | - | TEK | Tie2 | ANGPT1_TEK | Ligand-receptor | Paracrine | Glial cell | Glioblastoma cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | - | - | ANGPT | Angiogenesis | Inhibition | Brain | Brain | Malignant | Normal | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 31763674 | ΔNp73/ETS2 complex drives glioblastoma pathogenesis— targeti... |
Neuro-Oncology | Maren Cam et al. | 2020 |
| ANXA1 | - | FPR1 | - | ANXA1_FPR1 | Ligand-receptor | Autocrine | Malignant cell | Castration-resistant prostate cancer cell | Malignant cell | Castration-resistant prostate cancer cell | Human | - | - | - | - | IL6,EGFR | Activation,Activation | ANNEXIN | Proliferation | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Castration-resistant Prostate Cancer | Castration-resistant Prostate Cancer | pubmed | 32858191 | Annexin A1 promotes the nuclear localization of the epiderma... |
The international journal of biochemistry & cell biology | Sara Teixeira SoaresMota et al. | 2020 |
| APLN | Adipokine Apelin | APLNR | APJ | APLN_APLNR | Ligand-receptor | Paracrine | Adipocyte | Omental adipocyte | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | F13A1 | APLN inhibition receptor | CD36 | Activation | APELIN | Modulating lipid uptake,Metastasis | Activation,Activation | Embryo | Ovary | Normal | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34172534 | Adipokine Apelin/APJ Pathway Promotes Peritoneal Disseminati... |
Molecular cancer research | Samrita Dogra et al. | 2021 |
| ASPN | Asporin | CD44 | - | ASPN_CD44 | Ligand-receptor | Paracrine | Stellate cell | Activated pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | ASPN | Invasion,Migration | Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28400334 | Asporin promotes pancreatic cancer cell invasion and migrati... |
Cancer letters | Lili Wang et al. | 2017 |
| ASPN | Asporin | CD44 | - | ASPN_CD44 | Ligand-receptor | Autocrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | ASPN | EMT,Invasion,Migration | Activation,Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28400334 | Asporin promotes pancreatic cancer cell invasion and migrati... |
Cancer Letters | Lili Wang et al. | 2017 |
| ASPN | Asporin | CD44 | - | ASPN_CD44 | Ligand-receptor | Paracrine | Stellate cell | Pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | ASPN | EMT,Invasion,Migration | Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28400334 | Asporin promotes pancreatic cancer cell invasion and migrati... |
Cancer Letters | Lili Wang et al. | 2017 |
| BAG3 | - | IFITM2 | IFITM-2 | BAG3_IFITM2 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic ductal adenocarcinoma cell | Macrophage | Macrophage | Human | - | - | - | - | Cytokine | Activation | BAG | Tumor growth,Metastasis | Activation,Activation | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 28864347 | Role of BAG3 in cancer progression: A therapeutic opportunit... |
Seminars in Cell & Developmental Biology | Margot De Marco et al. | 2018 |
| BDNF | - | ERBB2 | - | BDNF_ERBB2 | Ligand-receptor | Paracrine | Astrocyte | Astrocyte | Malignant cell | Brain metastatic breast cancer cell | Human,Mouse | - | - | - | - | - | - | BDNF | Proliferation | Inhibition | Brain | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28446206 | Cooperation of neurotrophin receptor TrkB and Her2 in breast... |
Breast Cancer Research | Cecilia Choy et al. | 2017 |
| BDNF | - | NTRK2 | TrkB | BDNF_NTRK2 | Ligand-receptor | Paracrine | Astrocyte | Astrocyte | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | BDNF | Activation | BDNF | Invasion,Migration,Metastasis | Activation,Activation,Activation | Brain | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30796353 | Estradiol induces BDNF/TrkB signaling in triple-negative bre... |
Oncogene | Maria J Contreras-Zárate et al. | 2019 |
| BDNF | - | NTRK2 | TrkB | BDNF_NTRK2 | Ligand-receptor | Autocrine | Malignant cell | Triple-negative breast cancer cell | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | BDNF | Activation | BDNF | Invasion,Migration,Brain metastasis | Activation,Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30796353 | Estradiol induces BDNF/TrkB signaling in triple-negative bre... |
Oncogene | Maria J Contreras-Zárate et al. | 2019 |
| BDNF | - | TRK2 | - | BDNF_TRK2 | Ligand-receptor | Paracrine | Astrocyte | Astrocyte | Malignant cell | Brain metastatic breast cancer cell | Human,Mouse | - | - | - | - | - | - | BDNF | Proliferation | Inhibition | Brain | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28446206 | Cooperation of neurotrophin receptor TrkB and Her2 in breast... |
Breast Cancer Research | Cecilia Choy et al. | 2017 |
| Bmp | - | Bmpr1a | - | Bmp_Bmpr1a | Ligand-receptor | Paracrine | Mesenchymal cell | Intravillus and intercrypt mesenchymal cell | Stem cell | Lgr5+ stem cell | Mouse | - | - | - | - | - | - | BMP | Tumor initiation | Inhibition | Intestine | Intestine | Normal | Normal | - | - | - | - | - | - | pubmed | 28059064 | BMP restricts stemness of intestinal Lgr5+ stem cells by dir... |
Nature communications | Zhen Qi et al. | 2017 |
| BMP2 | - | BMPR2 | - | BMP2_BMPR2 | Ligand-receptor | Paracrine | TAN | Tumor-associated Neutrophil | Cancer stem cell | Hepatocellular carcinoma stem-like cell | Human | - | - | - | - | CXCL5 | Activation | BMP | Proliferation,Invasion | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30933361 | A Positive Feedback Loop between Cancer Stem-Like Cells and ... |
Hepatology | Shao‐Lai Zhou et al. | 2019 |
| BMP4 | BMP-4 | BMPR1A | - | BMP4_BMPR1A | Ligand-receptor | Autocrine | Malignant cell | Colorectal cancer cell | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | - | - | BMP | Survival | Activation | Colorectum | Colorectum | Malignant | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 28611046 | Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorec... |
Cancer research | Yuichiro Yokoyama et al. | 2017 |
| BMP4 | - | BMPR2 | - | BMP4_BMPR2 | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SMAD7 | Activation | BMP | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31941699 | Activation of Canonical BMP4-SMAD7 Signaling Suppresses Brea... |
Cancer research | Bedrich L Eckhardt et al. | 2020 |
| BMP4 | BMP-4 | BMPR2A | - | BMP4_BMPR2A | Ligand-receptor | Autocrine | Malignant cell | Colorectal cancer cell | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | - | - | BMP | Survival | Activation | Colorectum | Colorectum | Malignant | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 28611046 | Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorec... |
Cancer research | Yuichiro Yokoyama et al. | 2017 |
| C3 | - | C3ar1 | - | C3_C3ar1 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | MDSC | Myeloid-derived suppressor cell | Mouse | - | - | - | - | IL10 | Activation | COMPLEMENT | T cell immunity | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33633112 | PIWIL1 governs the crosstalk of cancer cell metabolism and i... |
Signal Transduction and Targeted Therapy | Ning Wang et al. | 2021 |
| C3 | C3a | C3AR1 | - | C3_C3AR1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | BCL2 | Activation | COMPLEMENT | Progression,Docetaxel resistance | Activation,Activation | Prostate | Prostate | Cancer-associated | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32238563 | Cancer epithelial-derived mitochondrial DNA is a targetable ... |
Proceedings of the National Academy of Sciences of the USA | Subhash Haldar et al. | 2020 |
| C5 | C5a | C5AR1 | - | C5_C5AR1 | Ligand-receptor | Paracrine | Stem cell | Mesenchymal stemlike cell | Malignant cell | Glioblastoma cell | Human,Mouse | - | - | - | - | ZEB1 | Activation | COMPLEMENT | Invasion | Inhibition | Brain | Brain | Normal | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 32179921 | Crosstalk between GBM cells and mesenchymal stemlike cells p... |
Neuro-Oncology | Eun-Jung Lim et al. | 2020 |
| CCL1 | - | CCR8 | - | CCL1_CCR8 | Ligand-receptor | Paracrine | TAM | Tumor-infiltrating macrophage | Malignant cell | Hepatoma cell | Human | - | - | - | - | PKM | Activation | PI3K | PKM2 excretion,Monocyte-to-Macrophage differentiation | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 32470318 | Ectosomal PKM2 Promotes HCC by Inducing Macrophage Different... |
Molecular cell | Pei-Pei Hou et al. | 2020 |
| CCL1 | - | CCR8 | - | CCL1_CCR8 | Ligand-receptor | Paracrine | Cancer stem cell | Breast cancer stem cell | T cell | CD4+ CD25+ Treg | Human,Mouse | - | - | - | - | - | - | CCL | Stemness | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | CD4+CD25+ Treg | Breast Cancer | Breast Cancer | pubmed | 29044882 | Sox2 Communicates with Tregs Through CCL1 to Promote the Ste... |
Stem cells | Yingxi Xu et al. | 2017 |
| CCL11 | - | CCR3 | - | CCL11_CCR3 | Ligand-receptor | Paracrine | MDSC | Myeloid-derived suppressor cell | Malignant cell | Non small cell lung cancer cell | Human,Mouse | - | - | - | - | CDH2,VIM,MMP | Activation | CCL | Metastasis | Inhibition | Lung | Lung | Normal | Malignant | - | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 33452453 | Myeloid-derived suppressor cells promote lung cancer metasta... |
Oncogene | Shouheng Lin et al. | 2021 |
| Ccl17 | - | Ccr4 | - | Ccl17_Ccr4 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | HIC1-deleted breast cancer cell | Mouse | - | - | - | - | - | - | CCL | Migration,Progression,Metastasis | Activation,Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30204129 | HIC1 deletion promotes breast cancer progression by activati... |
The Journal of Clinical Investication | Yingying Wang et al. | 2018 |
| CCL19 | - | CCR7 | - | CCL19_CCR7 | Ligand-receptor | Paracrine | Malignant cell | Colorectal cancer cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | miR206 | Activation | CCL | Angiogenesis | Inhibition | Colon | Colon | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30250188 | CCL19 suppresses angiogenesis through promoting miR-206 and ... |
Cell Death and Disease | Zhuoqing Xu et al. | 2018 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Macrophage | Alternatively activated macrophage | Epithelial cell | Pancreatic intraepithelial neoplasia (PanIN) cell | Human,Mouse | - | - | - | - | - | - | - | Pancreatic fibrogenesis,Tumorigenesis | Activation,Activation | Pancreas | Pancreas | Normal | Normal | - | - | M2 | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28514653 | The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio... |
Cell reports | Geou-YarhLiou et al. | 2017 |
| CCL2 | MCP1 | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Monocyte | Circulating CD14+ CCR2+ Monocyte | Human | - | - | - | - | - | - | CCL | Migration | Inhibition | Lung | Lung | Cancer-associated | Normal | - | - | - | CD14+ | Lung squamous cell carcinoma (LSCC) | Lung squamous cell carcinoma (LSCC) | pubmed | 32075803 | Cancer-Associated Fibroblasts Promote Immunosuppression by I... |
Cancer immunology research | Handan Xiang et al. | 2020 |
| Ccl2 | - | Ccr2 | - | Ccl2_Ccr2 | Ligand-receptor | Paracrine | Malignant cell | Bladder cancer cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | VEGFC | Activation | CCL | Lymphangiogenesis,Lymphatic metastasis | Activation,Activation | Bladder | Bladder | Malignant | Cancer-associated | - | - | - | - | LN-positive bladder cancer | LN-positive bladder cancer | pubmed | 30237493 | LNMAT1 promotes lymphatic metastasis of bladder cancer via C... |
Nature communications | Changhao Chen et al. | 2018 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Mural cell | Mural cell | Malignant cell | Tumor cell | Human,Mouse | - | - | - | - | - | - | CCL | Proliferation | Inhibition | Blood | Lung | Normal | Malignant | Mural-β3-integrin loss | - | - | - | Lung Cancer | Lung Cancer | pubmed | 32473126 | Cancer Burden is controlled by mural cell-b3-integrin regula... |
Cell | Ping-Pui Wong et al. | 2020 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Mural cell | Mural cell | Melanocyte | Tumor cell | Human,Mouse | - | - | - | - | - | - | CCL | Proliferation | Inhibition | Blood | Skin | Normal | Malignant | Mural-β3-integrin loss | - | - | - | Cutaneous melanoma | Cutaneous melanoma | pubmed | 32473126 | Cancer Burden is controlled by mural cell-b3-integrin regula... |
Cell | Ping-Pui Wong et al. | 2020 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Mural cell | Mural cell | Malignant cell | Tumor cell | Human,Mouse | - | - | - | - | - | - | CCL | Proliferation | Inhibition | Blood | Breast | Normal | Malignant | Mural-β3-integrin loss | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 32473126 | Cancer Burden is controlled by mural cell-b3-integrin regula... |
Cell | Ping-Pui Wong et al. | 2020 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Breast cancer cell | Human | - | - | - | - | - | - | CCL | Endocrine resistance | Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31710162 | Tumor-associated macrophages secrete CC-chemokine ligand 2 a... |
Cancer Sceince | Dongbo Li et al. | 2020 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Malignant cell | Lung metastatic cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | CDH2,VIM,MMP | Activation | CCL | Metastasis | Inhibition | Lung | Lung | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 29084208 | Transcription factor c-Myb inhibits breast cancer lung metas... |
Oncogene | L Knopfová et al. | 2018 |
| CCL2 | - | CCR2 | - | CCL2_CCR2 | Ligand-receptor | Paracrine | Lymphocyte | B cell acute lymphoblastic leukemia cell | Stromal cell | Bone marrow-derived mesenchymal stromal cell | Human,Mouse | - | - | - | - | POSTN | Activation | CCL | - | - | Blood | Bone marrow | Malignant | Normal | - | - | - | - | B cell acute lymphoblastic leukemia | B cell acute lymphoblastic leukemia | pubmed | 30726736 | Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo... |
Cell Reports | Zhenling Ma et al. | 2019 |
| CCL20 | - | CCR6 | - | CCL20_CCR6 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic ductal adenocarcinoma cell | T cell | Th17 cell | Human,Mouse | - | - | - | - | - | - | CCL | Invasion,Proliferation | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | T helper 17 | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31561620 | NF-κB Dependent Chemokine Signaling in Pancreatic Cancer | Cancers | Claudia Geismann et al. | 2019 |
| CCL20 | - | CCR6 | - | CCL20_CCR6 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic ductal adenocarcinoma cell | Dendritic cell | Dendritic cell | Human,Mouse | - | - | - | - | - | - | CCL | Invasion,Proliferation | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31561620 | NF-κB Dependent Chemokine Signaling in Pancreatic Cancer | Cancers | Claudia Geismann et al. | 2019 |
| CCL21 | - | CCR7 | - | CCL21_CCR7 | Ligand-receptor | Paracrine | Endothelial cell | Lymphatic endothelial cell | Malignant cell | Oral squamous cell carcinoma cell | Human | - | - | - | - | PROM1,CD44,ALDH1A1 | Activation,Activation,Activation | CCL | Stemness,Chemoresistance | Activation,Activation | Lymph | Oral | Normal | Malignant | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 32017846 | CCL21/CCR7 interaction promotes EMT and enhances the stemnes... |
Journal of cellular physiology | Yang Chen et al. | 2020 |
| CCL21 | - | CCR7 | - | CCL21_CCR7 | Ligand-receptor | Paracrine | Endothelial cell | Lymphatic endothelial cell | Malignant cell | Oral squamous cell carcinoma cell | Human | - | - | - | - | CDH1,CDH2,VIM | Activation,Activation,Activation | CCL | Migration,Invasion | Activation,Activation | Lymph | Oral | Normal | Malignant | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 32017846 | CCL21/CCR7 interaction promotes EMT and enhances the stemnes... |
Journal of cellular physiology | Yang Chen et al. | 2020 |
| CCL4 | MIP-1β | CCR5 | - | CCL4_CCR5 | Ligand-receptor | Paracrine | Macrophage | Alternatively activated macrophage | Mesothelial cell | Mesothelial cell | Human,Mouse | - | - | - | - | SELP | Activation | CCL | P-selectin expression | Inhibition | Ovary | Peritoneum | Normal | Normal | - | - | - | - | High grade serous ovarian cancer (HGSOC) | High grade serous ovarian cancer (HGSOC) | pubmed | 29739756 | Alternatively-Activated Macrophages Upregulate Mesothelial E... |
Cancer research | Molly J Carroll et al. | 2018 |
| CCL4 | - | CCR5 | - | CCL4_CCR5 | Ligand-receptor | Paracrine | T cell | CD8+ T cell | Glial cell | Microglia | Human,Mouse | - | - | - | - | CCL5 | Activation | CCL | - | - | Brain | Brain | Normal | Normal | - | - | CD8+ | - | Glioma | Glioma | pubmed | 32358581 | Midkine activation of CD8 + T cells establishes a neuron-imm... |
Nature communications | Xiaofan Guo et al. | 2020 |
| CCL5 | - | CCR5 | - | CCL5_CCR5 | Ligand-receptor | Paracrine | Malignant cell | Circulating tumor cell | T cell | Regulatory T cell | Human,Mouse | - | - | - | - | TGFB1 | Activation | CCL | Metastasis | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | T Regulatory | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 34215748 | Dissecting spatial heterogeneity and the immune-evasion mech... |
Nature Communications | Yun-Fan Sun et al. | 2021 |
| CCL5 | - | CCR5 | - | CCL5_CCR5 | Ligand-receptor | Paracrine | Pericyte | Pericyte | Malignant cell | Glioblastoma cell | Human,Mouse | - | - | - | - | - | - | CCL | Tumor Progression | Inhibition | Brain | Brain | Normal | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 34239070 | Pericytes augment glioblastoma cell resistance to temozolomi... |
Cell Research | Xiao-Ning Zhang et al. | 2021 |
| CCL5 | - | CCR5 | - | CCL5_CCR5 | Ligand-receptor | Paracrine | Endothelial cell | Endothelial cell | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | SERPINE1 | Activation | CCL | Angiogenesis | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 28899878 | Endothelial cells promote triple-negative breast cancer cell... |
FASEB journal : official publication of the Federation of Am... |
Wenwen Zhang et al. | 2018 |
| CCL5 | - | CCR5 | - | CCL5_CCR5 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | CD274 | Activation | CCL | Tumor growth | Inhibition | Colon | Colon | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31802034 | Macrophage-derived CCL5 facilitates immune escape of colorec... |
Cell Death & Differentiation | Chao Liu et al. | 2020 |
| CCL5 | - | CD44 | - | CCL5_CD44 | Ligand-receptor | Paracrine | Microglia | Microglia | Glial cell | Glioma cell | Human,Mouse | - | - | - | - | CREB | Activation | CCL | Tumor growth | Inhibition | Brain | Brain | Normal | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 32358581 | Midkine activation of CD8 + T cells establishes a neuron-imm... |
Nature communications | Xiaofan Guo et al. | 2020 |
| CCL7 | - | CCR1 | - | CCL7_CCR1 | Ligand-receptor | Autocrine | Malignant cell | Gastric cancer cell | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | MCAM,CCL7 | Activation,Activation | CCR1 | Migration,Invasion,Metastasis | Activation,Activation,Activation | Stomach | Stomach | Malignant | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 32616889 | SOX18 promotes gastric cancer metastasis through transactiva... |
Oncogene | Jie Chen et al. | 2020 |
| CCL7 | - | CCR3 | - | CCL7_CCR3 | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Malignant cell | ER+ breast cancer cell | Human | - | - | - | - | - | - | CCL | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 31419632 | Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance... |
iScience | Sumanta Chatterjee et al. | 2019 |
| CCL8 | - | CCR2 | - | CCL8_CCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | - | - | CCL | Metastasis | Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30930117 | Human Tumor-Associated Macrophage and Monocyte Transcription... |
Cancer cell | Luca Cassetta et al. | 2019 |
| CCL8 | - | CCR2 | - | CCL8_CCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Endometrial cancer cell | Human,Mouse | - | - | - | - | - | - | CCL | Metastasis | Activation,Activation | Uterus | Uterus | Cancer-associated | Malignant | - | - | - | - | Endometrial Cancer | Endometrial Cancer | pubmed | 30930117 | Human Tumor-Associated Macrophage and Monocyte Transcription... |
Cancer cell | Luca Cassetta et al. | 2019 |
| CCL8 | - | CCR5 | - | CCL8_CCR5 | Ligand-receptor | Paracrine | Endothelial cell | Endothelial colony-forming cell | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | IL8 | Activation | CCL | Proliferation,Invasion,Migration | Activation,Activation,Activation | Blood | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 33833397 | CCL8 mediates crosstalk between endothelial colony forming c... |
Oncogene | Eun-Sook Kim et al. | 2021 |
| CCN4 | WISP1 | ITGA6 | Integrin 𝛼6β1 | CCN4_ITGA6 | Ligand-receptor | Autocrine | Cancer stem cell | Glioma stem cell | Cancer stem cell | Glioma stem cell | Human | - | - | - | - | - | - | WNT | GSC proliferation,Self-renewal | Activation,Activation | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 32541784 | Dual Role of WISP1 in maintaining glioma stem cells and tumo... |
Nature communications | Weiwe Tao et al. | 2020 |
| CCN4 | WISP1 | ITGA6 | Integrin 𝛼6β1 | CCN4_ITGA6 | Ligand-receptor | Paracrine | Cancer stem cell | Glioma stem cell | TAM | Tumor-associated Macrophage | Human | - | - | - | - | - | - | WNT | M2 TAM survival,GBM growth | Activation,Activation | Brain | Brain | Malignant | Cancer-associated | - | - | - | M2 | Glioblastoma | Glioblastoma | pubmed | 32541784 | Dual Role of WISP1 in maintaining glioma stem cells and tumo... |
Nature communications | Weiwe Tao et al. | 2020 |
| CCN4 | WISP1 | ITGB1 | Integrin 𝛼6β1 | CCN4_ITGB1 | Ligand-receptor | Autocrine | Cancer stem cell | Glioma stem cell | Cancer stem cell | Glioma stem cell | Human | - | - | - | - | - | - | WNT | GSC proliferation,Self-renewal | Activation,Activation | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 32541784 | Dual Role of WISP1 in maintaining glioma stem cells and tumo... |
Nature communications | Weiwe Tao et al. | 2020 |
| CCN4 | WISP1 | ITGB1 | Integrin 𝛼6β1 | CCN4_ITGB1 | Ligand-receptor | Paracrine | Cancer stem cell | Glioma stem cell | TAM | Tumor-associated Macrophage | Human | - | - | - | - | - | - | WNT | M2 TAM survival,GBM growth | Activation,Activation | Brain | Brain | Malignant | Cancer-associated | - | - | - | M2 | Glioblastoma | Glioblastoma | pubmed | 32541784 | Dual Role of WISP1 in maintaining glioma stem cells and tumo... |
Nature communications | Weiwe Tao et al. | 2020 |
| Cd200 | - | Cd200r | - | Cd200_Cd200r | Ligand-receptor | Juxtacrine | Stem cell | Mesenchymal stem cell | Macrophage | Proinflammatory macrophage | Mouse | - | - | - | - | TNFAIP6 | Activation | CD200 | T cell Proliferation,Switching of macrophages phenotype | Inhibition,Activation | Uterus | Uterus | Normal | Normal | - | - | - | M1 | - | - | pubmed | 30778166 | Cell-cell contact with proinflammatory macrophages enhances ... |
Cellular & Molecular Immunology | Yanhong Li et al. | 2019 |
| CD24 | - | SELP | P-selectin | CD24_SELP | Ligand-receptor | Juxtacrine | Malignant cell | Ovarian cancer cell | Mesothelial cell | Mesothelial cell | Human,Mouse | - | - | - | - | - | - | PI3K | Metastasis | Activation | Ovary | Peritoneum | Malignant | Normal | - | - | - | - | High grade serous ovarian cancer (HGSOC) | High grade serous ovarian cancer (HGSOC) | pubmed | 29739756 | Alternatively-Activated Macrophages Upregulate Mesothelial E... |
Cancer research | Molly J Carroll et al. | 2018 |
| CD24 | - | SIGLEC10 | Siglec-10 | CD24_SIGLEC10 | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | CD24 | Tumor growth,Survival | Activation,Activation | Breast | Breast | Malignant | Cancer-associated | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 31367043 | CD24 signalling through macrophage Siglec-10 is a new target... |
Nature | Amira A Barkal et al. | 2019 |
| CD24 | - | SIGLEC10 | Siglec-10 | CD24_SIGLEC10 | Ligand-receptor | Paracrine | Malignant cell | Ovarian cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | CD24 | Tumor growth,Survival | Activation,Activation | Ovary | Ovary | Malignant | Cancer-associated | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 31367043 | CD24 signalling through macrophage Siglec-10 is a new target... |
Nature | Amira A Barkal et al. | 2019 |
| CD274 | PD-L1 | ITGB4 | - | CD274_ITGB4 | Ligand-receptor | Juxtacrine | Malignant cell | Cervical cancer cell | Malignant cell | Cervical cancer cell | Human,Mouse | - | - | - | - | - | - | ITGB4 | Tumor growth,Lymph node metastasis | Activation,Activation | Cervix | Cervix | Malignant | Malignant | - | - | - | - | Cervical Cancer | Cervical Cancer | pubmed | 29706653 | Programmed death ligand 1 promotes lymph node metastasis and... |
Oncogene | Shaojia Wang et al. | 2018 |
| Cd274 | PDL1 | Pdcd1 | PD1 | Cd274_Pdcd1 | Ligand-receptor | Juxtacrine | Malignant cell | Triple-negative breast cancer cell | T cell | T cell | Mouse | - | - | - | - | - | - | PD-L1 | Adaptive immunity | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 29367423 | Chemotherapy induces enrichment of CD47+/CD73+/ PDL1+ immune... |
Proceedings of the National Academy of Sciences of the Unite... |
Debangshu Samanta et al. | 2018 |
| CD274 | PD-L1 | PDCD1 | PDCD1 | CD274_PDCD1 | Ligand-receptor | Juxtacrine | B cell | B-lymphoma cell | T cell | CD8+ T cell | Human | - | - | - | - | - | - | PD-L1 | Immune invasion | Inhibition | Blood | Blood | Malignant | Normal | - | - | - | CD8+ | Diffuse large B-cell lymphoma (DLBCL) | Diffuse large B-cell lymphoma (DLBCL) | pubmed | 30925928 | MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody vi... |
Molecular Cancer | Zhong Zheng et al. | 2019 |
| CD274 | PD-L1 | PDCD1 | PD-1 | CD274_PDCD1 | Ligand-receptor | Juxtacrine | B cell | Antigen-presenting cell | T cell | T cell | Human,Mouse | - | - | - | - | PTPN11 | Activation | CD274 | T cell signaling | Inhibition | Spleen | Blood | Normal | Normal | - | - | - | CD8+ | - | - | pubmed | 32437509 | PD-1 and BTLA regulate T cell signaling differentially and o... |
The Journal of cell biology | Xiaozheng Xu et al. | 2020 |
| CD4 | - | MHC class II | MHC class II | CD4_MHC class II | Receptor-receptor | Juxtacrine | T cell | Cytotoxic CD4+ T cell | Malignant cell | Bladder tumor cell | Human | - | - | - | - | - | - | MHC-II | Activity of cytotoxic T cell | Inhibition | Bladder | Bladder | Normal | Malignant | - | - | CD4+cytotoxic | - | Bladder Cancer | Bladder Cancer | pubmed | 32497499 | Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in... |
Cell | David Y. Oh et al. | 2020 |
| Cd80 | - | Ctla4 | - | Cd80_Ctla4 | Ligand-receptor | Juxtacrine | Cancer stem cell | Tumor-initiating stem cell | T cell | Cytotoxic T lymphocyte | Mouse | - | - | - | - | - | - | CD80 | tSCs survival | Inhibition | Skin | Skin | Malignant | Normal | - | - | - | Cytotoxic | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 31031009 | Adaptive Immune Resistance Emerges from Tumor-Initiating Ste... |
Cell | Yuxuan Miao et al. | 2019 |
| CHI3L1 | - | IL13RA2 | IL-13Rα2 | CHI3L1_IL13RA2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | MMP | Activation | MAPK | Metastasis | Inhibition | Stomach | Stomach | Cancer-associated | Malignant | - | - | M2 | - | Gastric Cancer | Gastric Cancer | pubmed | 28143526 | Tumor-recruited M2 macrophages promote gastric and breast ca... |
Journal of Hematology & Oncology | Yulei Chen et al. | 2017 |
| CHI3L1 | - | IL13RA2 | IL-13Rα2 | CHI3L1_IL13RA2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | MMP | Activation | MAPK | Metastasis | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Breast Cancer | Breast Cancer | pubmed | 28143526 | Tumor-recruited M2 macrophages promote gastric and breast ca... |
Journal of Hematology & Oncology | Yulei Chen et al. | 2017 |
| CLCF1 | - | CNTFR | - | CLCF1_CNTFR | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | CXCL6,TGFB1 | Activation | CLCF1 | Self-renewal,Progression | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CNTF | - | CNTFR | CNTFR_LIFR_gp130 | CNTF_CNTFR | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC,MT-CO1,RPTOR | Activation | CNTF | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| CNTF | - | IL6ST | CNTFR_LIFR_gp130 | CNTF_IL6ST | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC,MT-CO1,RPTOR | Activation | CNTF | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| CNTF | - | LIFR | CNTFR_LIFR_gp130 | CNTF_LIFR | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC,MT-CO1,RPTOR | Activation | CNTF | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| Col1a1 | Type I collagen | Itga2 | GPVI | Col1a1_Itga2 | Ligand-receptor | Paracrine | Malignant cell | Circulating Tumor cell | Platelet | Platelet | Mouse | - | - | - | - | - | - | COLLAGEN | Cancer cell colonization,Cancer cell extravasation | Activation,Activation | Breast | Blood | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32015106 | Hsp47 promotes cancer metastasis by enhancing collagen-depen... |
Proceedings of the National Academy of Sciences of the Unite... |
Gaofeng Xiong et al. | 2020 |
| Col1a1 | Type I collagen | Itgb1 | Integrin α2β1 | Col1a1_Itgb1 | Ligand-receptor | Paracrine | Malignant cell | Circulating Tumor cell | Platelet | Platelet | Mouse | - | - | - | - | - | - | COLLAGEN | Cancer cell colonization,Cancer cell extravasation | Activation,Activation | Breast | Blood | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32015106 | Hsp47 promotes cancer metastasis by enhancing collagen-depen... |
Proceedings of the National Academy of Sciences of the Unite... |
Gaofeng Xiong et al. | 2020 |
| Col1a1 | Type I collagen | Itgb1 | Integrin α2β1 | Col1a1_Gp6 | Ligand-receptor | Paracrine | Malignant cell | Circulating Tumor cell | Platelet | Platelet | Mouse | - | - | - | - | - | - | COLLAGEN | Cancer cell colonization,Cancer cell extravasation | Activation,Activation | Breast | Blood | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32015106 | Hsp47 promotes cancer metastasis by enhancing collagen-depen... |
Proceedings of the National Academy of Sciences of the Unite... |
Gaofeng Xiong et al. | 2020 |
| COMP | - | CD36 | - | COMP_CD36 | Ligand-receptor | Paracrine | Stellate cell | Hepatic stellate cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | COMP | EMT,Proliferation,Metastasis | Activation,Activation,Activation | Liver | Liver | Normal | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30231922 | HSCs-derived COMP drives hepatocellular carcinoma progressio... |
Journal of experimental & clinical cancer research | Qing Li et al. | 2018 |
| Csf | - | Csf1r | - | Csf_Csf1r | Ligand-receptor | Paracrine | Malignant cell | Triple-negative breast cancer cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | EGF | Activation | CSF | - | - | Breast | Breast | Malignant | Cancer-associated | - | - | - | M2 | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 31911555 | miR-149 Suppresses Breast Cancer Metastasis by Blocking Para... |
Cancer Research | Ismael Sanchez-Gonzalez et al. | 2020 |
| CSF1 | - | CSF1R | - | CSF1_CSF1R | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | FERMT2 | CSF1 Agonist | - | - | - | - | CSF | Tumor growth | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28687620 | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac... |
Cancer Research | Khalid Sossey-Alaoui et al. | 2017 |
| CSF1 | - | CSF1R | - | CSF1_CSF1R | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | FERMT2 | CSF1 Agonist | - | - | - | - | CSF | Tumor growth | Inhibition | Breast | Breast | Malignant | Cancer-associated | - | - | - | M2 | Breast Cancer | Breast Cancer | pubmed | 28687620 | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac... |
Cancer Research | Khalid Sossey-Alaoui et al. | 2017 |
| Csf1 | - | Csf1r | - | Csf1_Csf1r | Ligand-receptor | Autocrine | Macrophage | Macrophage | Macrophage | Macrophage | Mouse | - | - | - | - | - | - | CSF | Metastasis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | M1 | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30902885 | Disruption of tumour-associated macrophage trafficking by th... |
Gut | Ying Zhu et al. | 2019 |
| CSF1 | - | CSF1R | - | CSF1_CSF1R | Ligand-receptor | Paracrine | TEC | GBM-associated endothelial cell | TAM | GBM-associated macrophage | Human,Mouse | - | - | - | - | ARG1 | Activation | CSF | Proliferation,Survival | Activation,Activation | Brain | Blood | Cancer-associated | Cancer-associated | - | - | - | M0 | Glioblastoma | Glioblastoma | pubmed | 29422647 | Vascular niche IL-6 induces alternative macrophage activatio... |
Nature communications | Qirui Wang et al. | 2018 |
| CSF1 | - | CSF1R | - | CSF1_CSF1R | Ligand-receptor | Paracrine | Stromal cell | Bone marrow stromal cell | TAM | Supportive monocytes/macrophage | Human,Mouse | - | - | - | - | Cytokine,HGF | Activation,Activation | CSF | Proliferation | Inhibition | Bone marrow | Bone marrow | Normal | Cancer-associated | - | - | - | - | Acute myeloid leukemia (AML) | Acute myeloid leukemia (AML) | pubmed | 30425048 | CSF1R inhibitors exhibit antitumor activity in acute myeloid... |
Blood | David K Edwards 5th et al. | 2019 |
| CSF1 | - | CSF1R | - | CSF1_CSF1R | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | CSF | Proliferation of macrophage | Inhibition | Breast | Breast | Malignant | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33161320 | Breast cancer cells and macrophages in a paracrine-juxtacrin... |
Biomaterials | Sevgi Onal et al. | 2021 |
| Cthrc1 | - | Tgfbr1 | - | Cthrc1_Tgfbr1 | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | αSMA,DES | Activation | TGFb | Liver fibrosis | Activation | Liver | Liver | Normal | Normal | - | - | - | - | Liver fibrosis | Liver fibrosis | pubmed | 30639416 | Autocrine CTHRC1 activates hepatic stellate cells and promot... |
ebiomedicine | Jun Li et al. | 2019 |
| Cthrc1 | - | Tgfbr2 | - | Cthrc1_Tgfbr2 | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | αSMA,DES | Activation | TGFb | Liver fibrosis | Activation | Liver | Liver | Normal | Normal | - | - | - | - | Liver fibrosis | Liver fibrosis | pubmed | 30639416 | Autocrine CTHRC1 activates hepatic stellate cells and promot... |
ebiomedicine | Jun Li et al. | 2019 |
| Cthrc1 | - | Tgfbr3 | - | Cthrc1_Tgfbr3 | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | αSMA,DES | Activation | TGFb | Liver fibrosis | Activation | Liver | Liver | Normal | Normal | - | - | - | - | Liver fibrosis | Liver fibrosis | pubmed | 30639416 | Autocrine CTHRC1 activates hepatic stellate cells and promot... |
ebiomedicine | Jun Li et al. | 2019 |
| Cthrc1 | - | Wnt_noncononical_receptor | - | Cthrc1_Wnt_noncononical_receptor | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | - | - | WNT | Contractility | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Liver fibrosis | Liver fibrosis | pubmed | 30639416 | Autocrine CTHRC1 activates hepatic stellate cells and promot... |
ebiomedicine | Jun Li et al. | 2019 |
| CTSC | - | PRTN3 | - | CTSC_PRTN3 | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | Neutrophil | Neutrophil | Human | - | - | - | - | IL6,CCL3 | Activation,Activation | CTSC | Metastasis | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33450198 | Cathepsin C promotes breast cancer lung metastasis by modula... |
Cancer cell | Yansen Xiao et al. | 2021 |
| CTSC | - | PRTN3 | - | CTSC_PRTN3 | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | Neutrophil | Neutrophil | Human | - | - | - | - | ROS | Activation | CTSC | Metastasis | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33450198 | Cathepsin C promotes breast cancer lung metastasis by modula... |
Cancer cell | Yansen Xiao et al. | 2021 |
| CTSK | - | TLR4 | - | CTSK_TLR4 | Ligand-receptor | Paracrine | Malignant cell | Colorectal cancer cell | TAM | Tumor-associated Macrophage | Human | - | - | - | - | IL10,IL17 | Activation,Activation | CTSK | M2 polarization | Inhibition | Colorectum | Colorectum | Malignant | Cancer-associated | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30850734 | Gut microbiota-stimulated cathepsin K secretion mediates TLR... |
Cell death and differentiation | Rui Li et al. | 2019 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Gastric cancer cell | Human | TNF | CXCL1 Agonist | - | - | STAT3 | Activation | CXCL | Migration,Metastasis | Activation,Activation | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30796034 | A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk betwe... |
Clinical cancer research | Zhijun Zhou et al. | 2019 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Inflammatory breast cancer cell | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Paracrine | Endothelial cell | Human pulmonary artery endothelial cell | Malignant cell | Osteosarcoma cell | Human,Mouse | - | - | - | - | VCAM1 | Activation | CXCL | Migration,Metastasis | Activation,Activation | Lung | Bone | Normal | Malignant | - | - | - | - | Osteosarcoma | Osteosarcoma | pubmed | 32079335 | CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in... |
Cancers | Chia-Chia Chao et al. | 2020 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Oral squamous cell carcinoma cell | Human,Mouse | - | - | - | - | - | - | CXCL | Invasion,Migration | Activation,Activation | Oral | Oral | Cancer-associated | Malignant | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 30616781 | Reciprocal activation of cancer-associated fibroblasts and o... |
Oral Oncology | Ling-YingWei et al. | 2019 |
| CXCL1 | - | CXCR2 | - | CXCL1_CXCR2 | Ligand-receptor | Autocrine | CAF | Cancer-associated Fibroblast | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | MMP1 | Activation | CXCL | Senescence | Inhibition | Oral | Oral | Cancer-associated | Cancer-associated | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 30616781 | Reciprocal activation of cancer-associated fibroblasts and o... |
Oral Oncology | Ling-YingWei et al. | 2019 |
| Cxcl10 | - | Cxcr3 | - | Cxcl10_Cxcr3 | Ligand-receptor | Paracrine | Dendritic cell | CD103+ dendritic cell | T cell | Effector T cell | Mouse | - | - | - | - | - | - | CXCL | Effector T cell recruitment | Inhibition | Skin | Skin | Malignant | Normal | - | - | CD103+ | CD8+ | Melanoma | Melanoma | pubmed | 28486109 | Tumor-Residing Batf3 Dendritic Cells Are Required for Effect... |
Cancer cell | Stefani Spranger et al. | 2017 |
| CXCL10 | - | CXCR3 | - | CXCL10_CXCR3 | Ligand-receptor | Paracrine | Malignant cell | HPV+ CSCC cell | Fibroblast | Fibroblast | Human,Mouse | - | - | - | - | CD247 | Activation | CXCL | Immune escape | Inhibition | Cervix | Cervix | Malignant | Normal | - | - | - | - | Cervical squamous cell carcinoma (CSCC) | Cervical squamous cell carcinoma (CSCC) | pubmed | 34422627 | CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimul... |
Frontiers in oncology | Xiaona Chen et al. | 2021 |
| Cxcl10 | - | Cxcr3 | - | Cxcl10_Cxcr3 | Ligand-receptor | Paracrine | CAF | Metastasis-associated fibroblast (MAF) | Malignant cell | Metastasis-initiating breast cancer cell | Mouse | - | - | - | - | IL1A,IL1B | Activation | CXCL | Metastasis | Inhibition | Lung | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| CXCL10 | - | CXCR3 | - | CXCL10_CXCR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | NK cell | NK cell | Human,Mouse | - | - | - | - | IFNG | Activation | CXCL | Anti-tumor immunity | Inhibition | Liver | Blood | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33689775 | Interferon regulatory factor 1(IRF-1) activates anti-tumor i... |
Cancer letters | Yihe Yan et al. | 2021 |
| CXCL10 | - | CXCR3 | - | CXCL10_CXCR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | NKT cell | NKT cell | Human,Mouse | - | - | - | - | IFNG | Activation | CXCL | Anti-tumor immunity | Inhibition | Liver | Blood | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33689775 | Interferon regulatory factor 1(IRF-1) activates anti-tumor i... |
Cancer letters | Yihe Yan et al. | 2021 |
| CXCL10 | - | CXCR3 | - | CXCL10_CXCR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | IFNG | Activation | CXCL | Anti-tumor immunity | Inhibition | Liver | Blood | Malignant | Normal | - | - | - | CD8+ | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33689775 | Interferon regulatory factor 1(IRF-1) activates anti-tumor i... |
Cancer letters | Yihe Yan et al. | 2021 |
| CXCL10 | - | CXCR3 | - | CXCL10_CXCR3 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | CXCL10 | Activation | CXCL | Proliferation,Metastasis,Angiogenesis | Activation,Activation,Activation | Liver | Blood | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33689775 | Interferon regulatory factor 1(IRF-1) activates anti-tumor i... |
Cancer letters | Yihe Yan et al. | 2021 |
| CXCL11 | - | CXCR3 | - | CXCL11_CXCR3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | IL17 | Activation | CXCL | Migration,Metastasis | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33707417 | Cancer-associated fibroblast -derived CXCL11 modulates hepat... |
Cell death & Disease | Gao Liu et al. | 2021 |
| CXCL11 | - | CXCR3 | - | CXCL11_CXCR3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | IL1B | Activation | CXCL | Migration,Metastasis | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33707417 | Cancer-associated fibroblast -derived CXCL11 modulates hepat... |
Cell death & Disease | Gao Liu et al. | 2021 |
| CXCL12 | - | CXCR4 | - | CXCL12_CXCR4 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | MAPK | Proliferation,Metastasis | Activation,Activation | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 31534521 | TCF12 promotes the tumorigenesis and metastasis of hepatocel... |
Theranostics | Jing Yang et al. | 2019 |
| CXCL12 | - | CXCR4 | - | CXCL12_CXCR4 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | PI3K | Proliferation,Metastasis | Activation,Activation | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 31534521 | TCF12 promotes the tumorigenesis and metastasis of hepatocel... |
Theranostics | Jing Yang et al. | 2019 |
| CXCL12 | SDF-1 | CXCR4 | - | CXCL12_CXCR4 | Ligand-receptor | Paracrine | Stellate cell | NF-κB activated pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | SMO | Activation | CXCL | Metastasis | Inhibition | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 28336327 | Galectin-1-driven upregulation of SDF-1 in pancreatic stella... |
Cancer letters | Dong Qian et al. | 2017 |
| CXCL12 | SDF-1 | CXCR4 | - | CXCL12_CXCR4 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Non small cell lung cancer cell | Human | - | - | - | - | PPARD | Activation | CXCL12 | Invasion,EMT | Activation,Activation | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 33637678 | Cancer-associated fibroblast-derived SDF-1 induces epithelia... |
Cell Death and Disease | Yingyan Wang et al. | 2021 |
| CXCL12 | - | CXCR4 | - | CXCL12_CXCR4 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | TAM | Tumor-associated Macrophage | Human | - | - | - | - | SERPINE1 | Activation | CXCL | Proliferation,Migration,Invasion,EMT | Activation,Activation,Activation,Activation | Liver | Liver | Cancer-associated | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 34195849 | Cancer‑associated fibroblast‑induced M2‑polarized macrophage... |
International journal of oncology | Shuhai Chen et al. | 2021 |
| CXCL13 | - | CXCR5 | - | CXCL13_CXCR5 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human | - | - | - | - | MIR934 | Activation | CXCL | Metastasis | Inhibition | Colon | Colon | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 33213490 | Tumor-derived exosomal miR-934 induces macrophage M2 polariz... |
Journal Hematology & Oncology | Senlin Zhao et al. | 2020 |
| Cxcl14 | - | Gpr85 | - | Cxcl14_Gpr85 | Ligand-receptor | Paracrine | Malignant cell | HIC1-deleted breast cancer cell | Fibroblast | Normal-associated Fibroblast | Mouse | - | - | - | - | CCL17 | Activation | CXCL14 | - | - | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30204129 | HIC1 deletion promotes breast cancer progression by activati... |
The Journal of Clinical Investication | Yingying Wang et al. | 2018 |
| CXCL16 | - | CXCR6 | - | CXCL16_CXCR6 | Ligand-receptor | Paracrine | Dendritic cell | CCR7+ dendritic cell | T cell | Cytotoxic T lymphocyte | Human,Mouse | - | - | - | - | - | - | CXCL | Tumor regression | Inhibition | - | - | Normal | Normal | - | - | CCR7+ DC3 | Cytotoxic CD8+ | Melanoma | Melanoma | pubmed | 34343496 | CXCR6 positions cytotoxic T cells to receive critical surviv... |
Cell | Mauro Di Pilato et al. | 2021 |
| CXCL2 | - | CXCR2 | - | CXCL2_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL2 | - | CXCR2 | - | CXCL2_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Inflammatory breast cancer cell | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL3 | - | CXCR2 | - | CXCL3_CXCR2 | Ligand-receptor | Paracrine | Malignant cell | Colon cancer cell | MDSC | Myeloid-derived suppressor cell | Human,Mouse | KRAS | CXCL3 Antagonist | - | - | - | - | CXCL | Decreasing cytotoxic T Cell | Inhibition | Colon | Myeloid | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30905761 | KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy ... |
Cancer Cell | Wenting Liao et al. | 2019 |
| Cxcl3 | - | Cxcr2 | - | Cxcl3_Cxcr2 | Ligand-receptor | Paracrine | Malignant cell | Colorectal cancer cell | MDSC | Myeloid-derived suppressor cell | Mouse | - | - | - | - | - | - | CXCL | Immune therapy resistance | Inhibition | Colon | Colon | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30905761 | KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy ... |
Cancer Cell | Wenting Liao et al. | 2019 |
| CXCL3 | - | CXCR2 | - | CXCL3_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL3 | - | CXCR2 | - | CXCL3_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Inflammatory breast cancer cell | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Gastric cancer cell | Human | TNF | CXCL5 Agonist | - | - | STAT3 | Activation | CXCL | Migration,Metastasis | Activation,Activation | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30796034 | A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk betwe... |
Clinical cancer research | Zhijun Zhou et al. | 2019 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | NPC cell | Malignant cell | NPC cell | Human,Mouse | - | - | - | - | CDH1,VIM | Inhibition,Activation | CXCL | Metastasis | Inhibition | Nasopharynx | Nasopharynx | Malignant | Malignant | - | - | - | - | Nasopharyngeal carcinoma (NPC) | Nasopharyngeal carcinoma (NPC) | pubmed | 29665837 | The CXCL5/CXCR2 axis contributes to the epithelial-mesenchym... |
Journal of experimental & clinical cancer research : CR | Wen-Ze Qiu et al. | 2018 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Colorectal cancer cell | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | MMP7 | Activation | CXCL | Invasion | Inhibition | Colon | Colon | Malignant | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 28356111 | Tumor-derived CXCL5 promotes human colorectal cancer metasta... |
Molecular Cancer | Jingkun Zhao et al. | 2017 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Colorectal cancer cell | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | SNAIL | Activation | CXCL | EMT | Inhibition | Colon | Colon | Malignant | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 28356111 | Tumor-derived CXCL5 promotes human colorectal cancer metasta... |
Molecular Cancer | Jingkun Zhao et al. | 2017 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Paracrine | Malignant cell | Colorectal cancer cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | FOXD1,VEGFA | Activation | CXCL | Angiogenesis | Inhibition | Colon | Colon | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30792394 | CXCL5 induces tumor angiogenesis via enhancing the expressio... |
Cell Death and Disease | Chun Chen et al. | 2019 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Melanocyte | Tumor cell | Human,Mouse | - | - | - | - | CD274 | Activation | CXCL | Immune invasion | Inhibition | Skin | Skin | Cancer-associated | Malignant | - | - | - | - | Melanoma | Melanoma | pubmed | 30873585 | Cancer‐associated fibroblasts promote PD‐L1 expression in mi... |
International Journal of Cancer | Ziqian Li et al. | 2019 |
| CXCL5 | - | CXCR2 | - | CXCL5_CXCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Tumor cell | Human,Mouse | - | - | - | - | CD274 | Activation | CXCL | Immune invasion | Inhibition | Colon | Colon | Cancer-associated | Malignant | - | - | - | - | Colorectal Carcinoma | Colorectal Carcinoma | pubmed | 30873585 | Cancer‐associated fibroblasts promote PD‐L1 expression in mi... |
International Journal of Cancer | Ziqian Li et al. | 2019 |
| CXCL6 | - | CNTFR | - | CXCL6_CNTFR | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | Neutrophil | Neutrophil | Human,Mouse | - | - | - | - | - | - | - | Recruitment | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | N1 | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CXCL6 | - | CXCR1 | - | CXCL6_CXCR1 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CLCF1 | Activation | CXCL | Tumor growth | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CXCL6 | - | CXCR1 | - | CXCL6_CXCR1 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | E2F1 | Activation | CXCL | Self-renewal | Inhibition | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CXCL6 | - | CXCR2 | - | CXCL6_CXCR2 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CLCF1 | Activation | CXCL | Tumor growth | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CXCL6 | - | CXCR2 | - | CXCL6_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | E2F1 | Activation | CXCL | Self-renewal | Inhibition | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| CXCL8 | IL-8 | CXCR1 | - | CXCL8_CXCR1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Fibroblast | Normal ovarian fibroblast | Human,Mouse | - | - | - | - | - | - | CXCL | Proliferation,Angiogenesis | Activation,Activation | Ovary | Ovary | Cancer-associated | Normal | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34277625 | Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ... |
Frontiers in cell and developmental biology | Zhaodong Ji et al. | 2021 |
| CXCL8 | IL-8 | CXCR1 | - | CXCL8_CXCR1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Proliferation,Stemness | Activation,Activation | Ovary | Ovary | Cancer-associated | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34277625 | Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ... |
Frontiers in cell and developmental biology | Zhaodong Ji et al. | 2021 |
| CXCL8 | - | CXCR1 | - | CXCL8_CXCR1 | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Malignant cell | ER+ breast cancer cell | Human | - | - | - | - | - | - | IL8 | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 31419632 | Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance... |
iScience | Sumanta Chatterjee et al. | 2019 |
| CXCL8 | IL-8 | CXCR1 | - | CXCL8_CXCR1 | Ligand-receptor | Paracrine | Stem cell | Mesenchymal stem cell | Malignant cell | Osteosarcoma cell | Human,Mouse | - | - | - | - | - | - | CXCL | Survival,Metastasis | Activation,Activation | Bone marrow | Bone | Normal | Malignant | - | - | - | - | Osteosarcoma | Osteosarcoma | pubmed | 29915309 | CXCR1/Akt signaling activation induced by mesenchymal stem c... |
Cell death & disease | Lin Du et al. | 2018 |
| CXCL8 | IL-8 | CXCR1 | - | CXCL8_CXCR1 | Ligand-receptor | Autocrine | Malignant cell | Osteosarcoma cell | Malignant cell | Osteosarcoma cell | Human,Mouse | - | - | - | - | - | - | CXCL | Survival,Metastasis | Activation,Activation | Bone | Bone | Malignant | Malignant | - | - | - | - | Osteosarcoma | Osteosarcoma | pubmed | 29915309 | CXCR1/Akt signaling activation induced by mesenchymal stem c... |
Cell death & disease | Lin Du et al. | 2018 |
| CXCL8 | IL8 | CXCR2 | - | CXCL8_CXCR2 | Ligand-receptor | Autocrine | Malignant cell | Inflammatory breast cancer cell | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL8 | IL8 | CXCR2 | - | CXCL8_CXCR2 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Inflammatory breast cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Metastasis | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Inflammatory breast cancer (IBC) | Inflammatory breast cancer (IBC) | pubmed | 31043378 | Inflammatory Breast Cancer Promotes Development of M2 Tumor-... |
Cancer research | Amanda Valeta-Magara et al. | 2019 |
| CXCL8 | IL-8 | CXCR2 | - | CXCL8_CXCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Fibroblast | Normal ovarian fibroblast | Human,Mouse | - | - | - | - | - | - | CXCL | Proliferation,Angiogenesis | Activation,Activation | Ovary | Ovary | Cancer-associated | Normal | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34277625 | Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ... |
Frontiers in cell and developmental biology | Zhaodong Ji et al. | 2021 |
| CXCL8 | IL-8 | CXCR2 | - | CXCL8_CXCR2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | - | - | - | - | CXCL | Proliferation,Stemness | Activation,Activation | Ovary | Ovary | Cancer-associated | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34277625 | Cancer-Associated Fibroblast-Derived Interleukin-8 Promotes ... |
Frontiers in cell and developmental biology | Zhaodong Ji et al. | 2021 |
| CXCL8 | IL-8 | CXCR2 | - | CXCL8_CXCR2 | Ligand-receptor | Paracrine | Malignant cell | Hypoxic colorectal cancer cell | Malignant cell | Normoxic colorectal cancer cell | Human | - | - | - | - | MMP1,MMP2 | Activation,Activation | CXCL | Metastasis | Inhibition | Colorectum | Colorectum | Malignant | Malignant | Hypoxic | Normoxic | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 32737283 | Hypoxic colorectal cancer cells promote metastasis of normox... |
Cell death & disease | Yulong Mi et al. | 2020 |
| Cxcl9 | - | Cxcr3 | - | Cxcl9_Cxcr3 | Ligand-receptor | Paracrine | Dendritic cell | CD103+ dendritic cell | T cell | Effector T cell | Mouse | - | - | - | - | - | - | CXCL | Effector T cell recruitment | Inhibition | Skin | Skin | Malignant | Normal | - | - | CD103+ | CD8+ | Melanoma | Melanoma | pubmed | 28486109 | Tumor-Residing Batf3 Dendritic Cells Are Required for Effect... |
Cancer cell | Stefani Spranger et al. | 2017 |
| Cxcl9 | - | Cxcr3 | - | Cxcl9_Cxcr3 | Ligand-receptor | Paracrine | CAF | Metastasis-associated fibroblast (MAF) | Malignant cell | Metastasis-initiating breast cancer cell | Mouse | - | - | - | - | IL1A,IL1B | Activation | CXCL | Metastasis | Inhibition | Lung | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| DKK1 | - | CKAP4 | - | DKK1_CKAP4 | Ligand-receptor | Paracrine | Malignant cell | Cholangiocarcinoma cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | PLVAP | Activation | DKK1 | Angiogenesis | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 34079085 | Plasmalemma vesicle-associated protein promotes angiogenesis... |
Oncogene | Yi Wang et al. | 2021 |
| Dkk2 | - | Lrp6 | - | Dkk2_Lrp6 | Ligand-receptor | Autocrine | Malignant cell | Colorectal cancer cell | Malignant cell | Colorectal cancer cell | Chicken,Mouse | - | - | - | - | - | - | PI3K | Aerobic glycolysis | Inhibition | Colon | Colon | Malignant | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30867812 | Tumor-secreted dickkopf2 accelerates aerobic glycolysis and ... |
Theranostics | Fengliu Deng et al. | 2019 |
| Dll1 | - | Notch3 | - | Dll1_Notch3 | Ligand-receptor | Juxtacrine | Stem cell | Mammary gland stem cell | Macrophage | Stromal macrophage | Mouse | - | - | - | - | WNT10A,WNT16,WNT3 | Activation,Activation,Activation | NOTCH | Maintain stem cell activity | Inhibition | Mammary gland | Mammary gland | Normal | Normal | - | - | - | - | - | - | pubmed | 29773667 | Notch ligand Dll1 mediates cross-talk between mammary stem c... |
Science | Rumela Chakrabarti et al. | 2018 |
| DUSP28 | - | ITGA1 | ITGα1 | DUSP28_ITGA1 | Ligand-receptor | Autocrine | Malignant cell | Metastatic pancreatic cancer cell | Malignant cell | Metastatic pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | MAPK | Migration,Invasion,Viability | Activation,Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 30902562 | Scattered DUSP28 is a novel biomarker responsible for aggrav... |
Cancer letters | Jungwhoi Lee et al. | 2019 |
| Ecm1 | - | Itga6 | - | Ecm1_Itga6 | Ligand-receptor | Paracrine | Cancer stem cell | Lgr5 cell | Epithelial cell | Alveolar type II (AT2) cell | Mouse | - | - | - | - | ABCG1 | Activation | ECM1 | Tumorigenesis | Inhibition | Lung | Lung | Malignant | Normal | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 32157214 | Identification of Sca-1+Abcg1+ bronchioalveolar epithelial c... |
Oncogene | Huijing Yin et al. | 2020 |
| Ecm1 | - | Itgb4 | - | Ecm1_Itgb4 | Ligand-receptor | Paracrine | Cancer stem cell | Lgr5 cell | Epithelial cell | Alveolar type II (AT2) cell | Mouse | - | - | - | - | ABCG1 | Activation | ECM1 | Tumorigenesis | Inhibition | Lung | Lung | Malignant | Normal | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 32157214 | Identification of Sca-1+Abcg1+ bronchioalveolar epithelial c... |
Oncogene | Huijing Yin et al. | 2020 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Breast cancer cell | Human,Mouse | FERMT2 | EGF Agonist | - | - | - | - | EGF | Tumor growth | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Breast Cancer | Breast Cancer | pubmed | 28687620 | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac... |
Cancer Research | Khalid Sossey-Alaoui et al. | 2017 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | FERMT2 | EGF Agonist | - | - | - | - | EGF | Tumor growth | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28687620 | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac... |
Cancer Research | Khalid Sossey-Alaoui et al. | 2017 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Juxtacrine | Macrophage | Macrophage | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | - | - | EGF | Tumor growth,Angiogenesis,Invasion,Metastasis | Activation,Activation,Activation,Activation | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33161320 | Breast cancer cells and macrophages in a paracrine-juxtacrin... |
Biomaterials | Sevgi Onal et al. | 2021 |
| Egf | - | Egfr | - | Egf_Egfr | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Triple Negative Breast Cancer cell | Mouse | - | - | - | - | - | - | EGF | Tumor progression,Metastasis | Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | M2 | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 31911555 | miR-149 Suppresses Breast Cancer Metastasis by Blocking Para... |
Cancer Research | Ismael Sanchez-Gonzalez et al. | 2020 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Squamous cell carcinoma cell | Malignant cell | Squamous cell carcinoma cell | Human | - | - | - | - | - | - | EGF | Progression | Inhibition | Esophagus | Esophagus | Malignant | Malignant | - | - | - | - | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 30190462 | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX... |
Nature communications | Yuan Jiang et al. | 2018 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Squamous cell carcinoma cell | Malignant cell | Squamous cell carcinoma cell | Human | - | - | - | - | - | - | EGF | Progression | Inhibition | Cervix | Cervix | Malignant | Malignant | - | - | - | - | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 30190462 | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX... |
Nature communications | Yuan Jiang et al. | 2018 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Squamous cell carcinoma cell | Malignant cell | Squamous cell carcinoma cell | Human | - | - | - | - | - | - | EGF | Progression | Inhibition | Lung | Lung | Malignant | Malignant | - | - | - | - | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 30190462 | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX... |
Nature communications | Yuan Jiang et al. | 2018 |
| EGF | - | EGFR | - | EGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Squamous cell carcinoma cell | Malignant cell | Squamous cell carcinoma cell | Human | - | - | - | - | - | - | EGF | Progression | Inhibition | Tongue | Tongue | Malignant | Malignant | - | - | - | - | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 30190462 | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX... |
Nature communications | Yuan Jiang et al. | 2018 |
| FAM3C | ILEI | LIFR | - | FAM3C_LIFR | Ligand-receptor | Autocrine | Cancer stem cell | Breast cancer stem cell | Cancer stem cell | Breast cancer stem cell | Human,Mouse | - | - | IL6ST | FAM3C activation receptor | - | - | FAM3C | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30692635 | TGFβ promotes breast cancer stem cell self-renewal through a... |
Oncogene | Alec N Woosley et al. | 2019 |
| Faslg | FasL | Fas | - | Faslg_Fas | Ligand-receptor | Juxtacrine | Macrophage | CD11b+F4/80+ monocyte-derived macrophage | T cell | CD8+ T cell | Mouse | - | - | - | - | - | - | FASLG | T cell apoptosis | Inhibition | Liver | Liver | Normal | Normal | - | - | CD11b+F4/80+ | CD8+ | Liver Metastasis | Liver Metastasis | pubmed | 33398162 | Liver metastasis restrains immunotherapy efficacy via macrop... |
Nature medicine | Jiali Yu et al. | 2021 |
| Fasn | - | Cd36 | - | Fasn_Cd36 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Colorectal cancer cell | Mouse | - | - | - | - | VIM,CDH1 | Activation,Inhibition | LIPID | Metastasis | Inhibition | Colon | Colon | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 32327627 | Reprogramming of lipid metabolism in cancer-associated fibro... |
Cell Death and Disease | Jin Gong, Yiyun Lin et al. | 2020 |
| FGF18 | - | FGFR2 | - | FGF18_FGFR2 | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | YAP1 | Activation | FGF | Tumor growth | Inhibition | Stomach | Stomach | Malignant | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 32934314 | FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 ... |
Oncogene | Jinglin Zhang et al. | 2020 |
| FGF18 | - | FGFR3 | - | FGF18_FGFR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | - | - | FGF | Angiogenesis | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 29242604 | Ribosomal protein S15a promotes tumor angiogenesis via enhan... |
Oncogene | Pengyi guo et al. | 2018 |
| FGF19 | - | FGF4 | - | FGF19_FGF4 | Ligand-receptor | Autocrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | FGF19 | Activation | FGF | Proliferation,Invasion | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33066597 | FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr... |
Cancers | Norihiko Sasaki et al. | 2020 |
| FGF19 | - | FGF4 | - | FGF19_FGF4 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | - | - | FGF | Proliferation,Invasion | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33066597 | FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr... |
Cancers | Norihiko Sasaki et al. | 2020 |
| FGF19 | - | KLB | - | FGF19_KLB | Ligand-receptor | Autocrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | FGF19 | Activation | FGF | Proliferation,Invasion | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33066597 | FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr... |
Cancers | Norihiko Sasaki et al. | 2020 |
| FGF19 | - | KLB | - | FGF19_KLB | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | - | - | FGF | Proliferation,Invasion | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33066597 | FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Pr... |
Cancers | Norihiko Sasaki et al. | 2020 |
| FGF2 | - | FGFR | - | FGF2_FGFR | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | ER+ breast cancer cell | Human,Mouse | - | - | - | - | RB1,BCL2L11 | Activation,Activation | FGFR | Apoptosis,Survival | Inhibition,Activation | Bone marrow | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 29436393 | Therapeutically targeting tumor microenvironment–mediated dr... |
Journal of Experimental Medicine | Kevin Shee et al. | 2018 |
| FGF2 | - | FGFR | - | FGF2_FGFR | Ligand-receptor | Paracrine | Malignant cell | HNSCC cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | HGF | Activation | FGFR | Progression | Inhibition | Tongue | Tongue | Malignant | Cancer-associated | - | - | - | - | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | pubmed | 29769197 | Cancer-associated fibroblasts drive glycolysis in a targetab... |
Cancer Research | Dhruv Kumar et al. | 2018 |
| FGF2 | - | FGFR1 | - | FGF2_FGFR1 | Ligand-receptor | Autocrine | Malignant cell | Esophageal squamous cell | Malignant cell | Esophageal squamous cell | Human | - | - | - | - | - | - | FGF | Cancer survival,Migration | Activation,Activation | Esophagus | Esophagus | Malignant | Malignant | - | - | - | - | Esophageal squamous cell carcinoma | Esophageal squamous cell carcinoma | pubmed | 27317650 | NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microe... |
Cancer Letters | Nobuhisa Takase et al. | 2016 |
| FGF2 | - | FGFR1 | - | FGF2_FGFR1 | Ligand-receptor | Paracrine | Malignant cell | Esophageal squamous cell | TAM | Tumor-associated Macrophage | Human | - | - | NCAM1 | FGF2 activation receptor | - | - | FGF | Cancer survival,Migration | Activation,Activation | Esophagus | Esophagus | Malignant | Cancer-associated | - | - | - | M2 | Esophageal squamous cell carcinoma | Esophageal squamous cell carcinoma | pubmed | 27317650 | NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microe... |
Cancer Letters | Nobuhisa Takase et al. | 2016 |
| FGF2 | - | FGFR1 | - | FGF2_FGFR1 | Ligand-receptor | Paracrine | CAF | Tumor fibroblast | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | SPRY1 | Activation | FGF | T cell activation | Inhibition | Esophagus | Esophagus | Cancer-associated | Normal | - | - | - | CD8+ | Esophageal Cancer | Esophageal Cancer | pubmed | 33093168 | Tumor Fibroblast-Derived FGF2 Regulates Expression of SPRY1 ... |
Cancer Research | Qing-Yun Chen et al. | 2020 |
| FGF2 | - | FGFR2 | FGF2R | FGF2_FGFR2 | Ligand-receptor | Paracrine | Epithelial cell | Keratinocyte | Melanocyte | Melanocyte | Human | - | - | - | - | MITF | Activation | FGF | Melanogenesis | Inhibition | Skin | Skin | Normal | Normal | - | - | - | - | Disorders of skin pigmentation | Disorders of skin pigmentation | pubmed | 31115052 | Ganoderma lucidum polysaccharide reduces melanogenesis by in... |
Journal of cellular physiology | Ling Jiang et al. | 2019 |
| FGF2 | - | FGFR2 | FGF2R | FGF2_FGFR2 | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Melanocyte | Melanocyte | Human | - | - | - | - | MITF | Activation | FGF | Melanogenesis | Inhibition | Skin | Skin | Normal | Normal | - | - | - | - | Disorders of skin pigmentation | Disorders of skin pigmentation | pubmed | 31115052 | Ganoderma lucidum polysaccharide reduces melanogenesis by in... |
Journal of cellular physiology | Ling Jiang et al. | 2019 |
| FGF2 | FGF | FGFR3 | FGFR | FGF2_FGFR3 | Ligand-receptor | Autocrine | Plasma cell | Plasma cell | Plasma cell | Plasma cell | Human,Mouse | - | - | - | - | MYC,GSH | Inhibition,Inhibition | FGF | Tumor growth | Inhibition,Inhibition | Bone | Bone | Malignant | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 32094301 | FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc ... |
Cancer research | Roberto Ronca et al. | 2020 |
| FGF2 | FGF | FGFR3 | FGFR | FGF2_FGFR3 | Ligand-receptor | Paracrine | Plasma cell | Plasma cell | Plasma cell | Plasma cell | Human,Mouse | - | - | - | - | MYC,GSH | Inhibition,Inhibition | FGF | Tumor growth,Apoptosis | Inhibition,Inhibition | Bone | Bone | Malignant | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 32094301 | FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc ... |
Cancer research | Roberto Ronca et al. | 2020 |
| FGF4 | - | FGFR1 | - | FGF4_FGFR1 | Ligand-receptor | Paracrine | Malignant cell | Lymphoma cell | TEC | Tumor-associated Endothelial cell | Human,Mouse | - | - | - | - | ETS2 | Activation | FGF4 | Feed-forward FGFR1-ETS2 angiocrine cascade | Activation | Lymph | Lymph | Malignant | Cancer-associated | - | - | - | - | Lymphoma | Lymphoma | pubmed | 27989801 | Molecular Checkpoint Decisions Made by Subverted Vascular Ni... |
Cancer Cell | Zhongwei Cao et al. | 2017 |
| FGL1 | - | LAG3 | - | FGL1_LAG3 | Ligand-receptor | Paracrine | Malignant cell | Tumor cell | T cell | T cell | Human,Mouse | - | - | - | - | - | - | FGL1 | Immune invasion | Inhibition | Lung | Blood | Malignant | Normal | - | - | - | - | Non-small cell lung carcinomas (NSCLC) | Non-small cell lung carcinomas (NSCLC) | pubmed | 30580966 | Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligan... |
Cell | Jun Wang et al. | 2019 |
| FGL2 | - | FCGR3A | CD16 | FGL2_FCGR3A | Ligand-receptor | Paracrine | Glial cell | Glioma cell | Macrophage | Macrophage | Human,Mouse | - | - | - | - | PPBP | Activation | FCGR3A | Progression | Inhibition | Brain | Brain | Malignant | Normal | - | - | - | - | Glioma | Glioma | pubmed | 33676940 | FGL2-wired macrophages secrete CXCL7 to regulate the stem-li... |
Cancer Letters | JunYan et al. | 2021 |
| FLRT3 | - | LPHN | - | FLRT3_LPHN | Ligand-receptor | Autocrine | Malignant cell | MCF-7 breast cancer cell | Malignant cell | MCF-7 breast cancer cell | Human | - | - | - | - | LGALS9 | Activation | FLRT3 | Cytotoxic T cell-induced death,Protect cancer cell | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31354733 | The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms i... |
Frontiers in immunology | Inna M Yasinska et al. | 2019 |
| GAS6 | Gas6 | AXL | - | GAS6_AXL | Ligand-receptor | Paracrine | Stromal cell | Bone marrow-derived stromal cell | Cancer stem cell | Leukemia stem cell | Human,Mouse | - | - | - | - | - | - | GAS | Self-renewal capacity | Inhibition | Bone marrow | Bone marrow | Normal | Malignant | - | - | - | - | Chronic Myelogenous Leukemia (CML) | Chronic Myelogenous Leukemia (CML) | pubmed | 27852702 | Gas6/Axl Signaling regulates Self-renewal of chronic myeloge... |
Clinical cancer research : an official journal of the Americ... |
Yanli Jin et al. | 2017 |
| GAS6 | - | AXL | - | GAS6_AXL | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Non small cell lung cancer cell | Human,Mouse | - | - | - | - | - | - | GAS | EMT | Inhibition | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 32909687 | The actin modulator hMENA regulates GAS6-AXL axis and pro-tu... |
EMBO reports | Roberta Melchionna et al. | 2020 |
| GAS6 | - | AXL | - | GAS6_AXL | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | - | - | GAS | EMT | Inhibition | Pancreas | Pancreas | Cancer-associated | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 32909687 | The actin modulator hMENA regulates GAS6-AXL axis and pro-tu... |
EMBO reports | Roberta Melchionna et al. | 2020 |
| GAS6 | - | MERTK | - | GAS6_MERTK | Ligand-receptor | Autocrine | B cell | Multiple myeloma cell | B cell | Multiple myeloma cell | Human | - | - | - | - | - | - | GAS6 | Apoptosis,Proliferation | Inhibition,Activation | Blood | Blood | Malignant | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 28154173 | Autocrine and Paracrine Interactions between Multiple Myelom... |
Journal of Biological Chemistry | Miki Furukawa et al. | 2017 |
| GAS6 | - | MERTK | - | GAS6_MERTK | Ligand-receptor | Paracrine | Stromal cell | Bone marrow stromal cell | B cell | Multiple myeloma cell | Human | - | - | - | - | - | - | GAS6 | Apoptosis,Proliferation | Inhibition,Activation | Bone marrow | Blood | Normal | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 28154173 | Autocrine and Paracrine Interactions between Multiple Myelom... |
Journal of Biological Chemistry | Miki Furukawa et al. | 2017 |
| GAS6 | - | MERTK | - | GAS6_MERTK | Ligand-receptor | Paracrine | Stromal cell | Bone marrow stromal cell | B cell | Multiple myeloma cell | Human | - | - | - | - | ICAM1,IL6 | Activation | GAS6 | Proliferation,Migration,Apoptosis | Activation,Activation,Inhibition | Bone marrow | Blood | Normal | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 28154173 | Autocrine and Paracrine Interactions between Multiple Myelom... |
Journal of Biological Chemistry | Miki Furukawa et al. | 2017 |
| Gcg | Glucagon | Gcgr | Glucagon receptor | Gcg_Gcgr | Ligand-receptor | Paracrine | α cell | α cell | β cell | β cell | Mouse | - | - | - | - | INS | Activation | GCG | - | - | Pancreas | Pancreas | Normal | Normal | - | - | - | - | - | - | pubmed | 30380405 | Insulin Secretion Depends on Intra-islet Glucagon Signaling | Cell press | Berit Svendsen et al. | 2018 |
| Gcg | Glucagon | Glp1r | GLP-1R | Gcg_Glp1r | Ligand-receptor | Paracrine | α cell | α cell | β cell | β cell | Mouse | - | - | - | - | INS | Activation | GCG | - | - | Pancreas | Pancreas | Normal | Normal | - | - | - | - | - | - | pubmed | 30380405 | Insulin Secretion Depends on Intra-islet Glucagon Signaling | Cell press | Berit Svendsen et al. | 2018 |
| GDF15 | - | GFRAL | - | GDF15_GFRAL | Ligand-receptor | Paracrine | Stellate cell | Hepatic stellate cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | GDF15 | Proliferation | Inhibition | Liver | Liver | Normal | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33346004 | Hepatic Stellate Cells in hepatocellular carcinoma promote t... |
Gastroenterology | Yuta Myojin et al. | 2021 |
| Gdf3 | Gdf3 | Acvr1c | ALKs | Gdf3_Acvr1c | Ligand-receptor | Paracrine | Macrophage | Adipose tissue macrophage | Adipocyte | Adipocyte | Mouse | - | - | - | - | - | - | GDF3 | Lipolysis | Inhibition | Adipose | Adipose | Normal | Normal | - | - | - | - | High-fat diet-induced (HFD-induced) obesity | High-fat diet-induced (HFD-induced) obesity | pubmed | 33830083 | Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3... |
JCI insight | Xiangming Hu et al. | 2021 |
| GDNF | - | RET | - | GDNF_RET | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Human,Mouse | - | - | TGFBR1 | GDNF activation receptor | αSMA,CoI1,GDNF | Activation | GDNF | Fibrogenesis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Liver fibrosis | Liver fibrosis | pubmed | 31171625 | Glial cell line-derived neurotrophic factor (GDNF) mediates ... |
Gut | Le Tao et al. | 2019 |
| GPI | - | GPER1 | - | GPI_GPER1 | Ligand-receptor | Autocrine | Malignant cell | Endometrium cancer cell | Malignant cell | Endometrium cancer cell | Human | - | - | - | - | - | - | PI3K | Endometrial cancer cell growth | Inhibition | Endometrium | Endometrium | Malignant | Malignant | - | - | - | - | Endometrial Cancer | Endometrial Cancer | pubmed | 30836961 | Autocrine motility factor promotes endometrial cancer progre... |
Cell Communication and Signaling | Yiran Li et al. | 2019 |
| HBEGF | HB-EGF | EGFR | - | HBEGF_EGFR | Ligand-receptor | Autocrine | Malignant cell | Cervical cancer cell | Malignant cell | Cervical cancer cell | Human,Mouse | - | - | - | - | - | - | EGF | Proliferation | Inhibition | Cervix | Cervix | Malignant | Malignant | - | - | - | - | Cervical Cancer | Cervical Cancer | pubmed | 28498437 | Autocrine expression of the epidermal growth factor receptor... |
International Journal of Oncology | Marlies Schrevel et al. | 2017 |
| HBEGF | - | EGFR | ErbB1 | HBEGF_EGFR | Ligand-receptor | Paracrine | Endothelial cell | Endothelial cell | Cardiomyocyte | Cardiomyocyte | Human,Mouse | - | - | - | - | - | - | EGF | Cardiomyocyte growth | Inhibition | Heart | Heart | Normal | Normal | - | - | - | - | Cardiac Hypertrophy | Cardiac Hypertrophy | pubmed | 30922063 | Endothelial Cells Regulate Physiological Cardiomyocyte Growt... |
Circulation | Riikka Kivelä et al. | 2019 |
| HGF | - | MET | - | HGF_MET | Ligand-receptor | Paracrine | Myofibroblast | Bone marrow-derived myofibroblasts (BMFs) | Malignant cell | Gastric cancer cell | Human | - | - | - | - | - | - | HGF | - | - | Bone marrow | Stomach | Normal | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 27109105 | Crosstalk between bone marrow-derived myofibroblasts and gas... |
Oncogene | Liming Zhu et al. | 2016 |
| HGF | - | MET | c-Met | HGF_MET | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | MET-unamplified gastric cancer cell | Human | - | - | - | - | TWIST1 | Activation | HGF | Metastasis | Inhibition | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30158543 | HGF-mediated crosstalk between cancer-associated fibroblasts... |
Cell death & disease | Xusheng Ding et al. | 2018 |
| HGF | - | MET | - | HGF_MET | Ligand-receptor | Paracrine | Stellate cell | Hepatic stellate cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | STMN1, PDGFB | Activation,Activation | HGF | Tumor growth | Inhibition | Liver | Liver | Normal | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 31785057 | STMN1 upregulation mediates hapatocellular carcinoma and hep... |
Cancer science | Rui Zhang et al. | 2020 |
| HGF | - | MET | c-MET | HGF_MET | Ligand-receptor | Paracrine | TAM | AML support cell | Blast | AML blast | Human,Mouse | - | - | - | - | - | - | HGF | Proliferation,Differentiation | Activation,Activation | Bone marrow | Bone marrow | Cancer-associated | Malignant | - | - | - | - | Acute myeloid leukemia (AML) | Acute myeloid leukemia (AML) | pubmed | 30425048 | CSF1R inhibitors exhibit antitumor activity in acute myeloid... |
Blood | David K Edwards 5th et al. | 2019 |
| HGF | - | MET | c-Met | HGF_MET | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | HNSCC cell | Human,Mouse | - | - | - | - | FGF2 | Activation | MET | Progression | Inhibition | Tongue | Tongue | Cancer-associated | Malignant | - | - | - | - | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | pubmed | 29769197 | Cancer-associated fibroblasts drive glycolysis in a targetab... |
Cancer Research | Dhruv Kumar et al. | 2018 |
| Hgf | - | Rnmt | cMet | Hgf_Rnmt | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Cancer stem cell | Tumor-initiating cell | Mouse | - | - | - | - | HEY1 | Activation | HGF | Tumorigenesis,Self-renewal | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 27134167 | Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell... |
Cell reports | Eunice Yuen Ting Lau et al. | 2016 |
| High mannose N-glycan | - | Mannose receptor | - | High mannose N-glycan_Mannose receptor | Ligand-receptor | Juxtacrine | Cancer stem cell | CD133+ hepatoma stem cell | Endothelial cell | Lymphatic endothelial cell | Human | - | - | - | - | IL17A | Activation | - | - | - | Liver | Lymph | Malignant | Normal | - | - | CD133+ | - | Hepatoma | Hepatoma | pubmed | 31499129 | IL-17A secreted from lymphatic endothelial cells promotes tu... |
Journal of Hepatology | Yuanyan Wei et al. | 2019 |
| HMGA1 | - | AGER | RAGE | HMGA1_AGER | Ligand-receptor | Autocrine | Malignant cell | Triple-negative breast cancer cell | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | HMGA1 | Activation | HMGA1 | Migration,Invasion | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30135148 | Extracellular HMGA1 Promotes Tumor Invasion and Metastasis i... |
Clinical Cancer Research | Olga Méndez et al. | 2018 |
| HMGB1 | - | TLR4 | - | HMGB1_TLR4 | Ligand-receptor | Paracrine | Malignant cell | Damaged tumour cell | Myeloid cell | TLR4-positive myeloid cell | Human | - | - | - | - | TGFB1 | Activation | HMGB1 | Immune,Tumor growth | Inhibition,Activation | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34234778 | High Mobility Group Box 1(HMGB1) Induces Toll-Like Receptor ... |
Frontiers in immunology | Anette Teo Hansen Selnø et al. | 2021 |
| HMGB1 | - | TLR4 | - | HMGB1_TLR4 | Ligand-receptor | Paracrine | Malignant cell | Damaged tumour cell | Myeloid cell | TLR4-positive myeloid cell | Human | - | - | - | - | TGFB1 | Activation | HMGB1 | Immune,Tumor growth | Inhibition,Activation | Colorectum | Colorectum | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 34234778 | High Mobility Group Box 1(HMGB1) Induces Toll-Like Receptor ... |
Frontiers in immunology | Anette Teo Hansen Selnø et al. | 2021 |
| ICAM1 | - | ITGB1 | - | ICAM1_ITGB1 | Ligand-receptor | Juxtacrine | Neutrophil | Neutrophil | Epithelial cell | Cholangiocyte | Human | - | - | - | - | ITPR3 | Inhibition | ICAM | Cholestasis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Alcoholic hepatitis (AH) | Alcoholic hepatitis (AH) | pubmed | 33214166 | Neutrophils interact with cholangiocytes to cause cholestati... |
Gut | Masahiro Takeuchi et al. | 2020 |
| Ifn | Type 1 IFN | Ifnar1 | - | Ifn_Ifnar1 | Ligand-receptor | Paracrine | Epithelial cell | Non-tumor cell | NK cell | Natural killer (NK) cell | Mouse | - | - | - | - | - | - | - | NK cell anti-tumor immunity | Inhibition | Skin | Skin | Normal | Normal | - | - | - | - | Melanoma | Melanoma | pubmed | 30332631 | Tumor-derived cGAMP triggers a STING-mediated interferon res... |
Immunity | Assaf Marcus et al. | 2018 |
| Ifng | IFN-γ | Ifngr1 | IFN-γR | Ifng_Ifngr1 | Ligand-receptor | Paracrine | T cell | CD8+ T cell | Malignant cell | Liver cancer cell | Mouse | - | - | - | - | CXCL9,CXCL10 | Activation,Activation | IFN-II | Proliferation | Inhibition | Liver | Liver | Normal | Malignant | - | - | CD8+ | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33191170 | Nanoparticle -Mediated Delivery of 2-Deoxy-D-Glucose Induces... |
Cellular and molecular gastroenterology and hepatology | Kyo Sasaki et al. | 2021 |
| Ifng | - | Ifngr1 | - | Ifng_Ifngr1 | Ligand-receptor | Paracrine | T cell | T cell | Stem cell | Neural stem cell (NSC) | Mouse | - | - | - | - | BST2 | Activation | IFN-II | Proliferation | Inhibition | Brain | Brain | Normal | Normal | Brain aging | Brain aging | CD8+ | - | - | Brain Ageing | pubmed | 31270459 | Single-cell analysis reveals T cell infiltration in old neur... |
Nature | Ben W Dulken et al. | 2019 |
| IFNG | - | IFNGR1 | - | IFNG_IFNGR1 | Ligand-receptor | Paracrine | T cell | CD8+ T cell | Malignant cell | Cancer cell | Human,Mouse | - | - | - | - | MHC classⅠgene | Activation | IFN-II | MHC-Ⅰantigen presentation | Inhibition | Lung | Lung | Normal | Malignant | - | - | CD8+ | - | Small-cell lung cancer | Small-cell lung cancer | pubmed | 31564637 | An Evolutionarily Conserved Function of Polycomb Silences th... |
Immunity | Marian L. Burr et al. | 2019 |
| IFNG | - | IFNGR1 | - | IFNG_IFNGR1 | Ligand-receptor | Paracrine | T cell | T cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | CD274 | Activation | IFNG | Proliferation | Inhibition | Liver | Liver | Normal | Malignant | - | - | CD8+ | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 31678303 | Disruption of SIRT7 Increases the Efficacy of Checkpoint Inh... |
Gastroenterology | Junyu Xiang et al. | 2020 |
| IGF1 | - | IGF1R | - | IGF1_IGF1R | Ligand-receptor | Paracrine | TEC | Tumor-associated endothelial cell | Malignant cell | Lymphoma cell | Human,Mouse | IGFBP7 | IGF1 Antagonist | - | - | - | - | IGF | Chemoresistance | Inhibition | Lymph | Lymph | Cancer-associated | Malignant | - | - | - | - | Lymphoma | Lymphoma | pubmed | 27989801 | Molecular Checkpoint Decisions Made by Subverted Vascular Ni... |
Cancer Cell | Zhongwei Cao et al. | 2017 |
| IGF2 | - | IGF1R | - | IGF2_IGF1R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | ASCC cell | Human | - | - | - | - | - | - | IGF | Tumor growth | Inhibition | Anus | Anus | Cancer-associated | Malignant | - | - | - | - | Anal squamous cell carcinoma | Anal squamous cell carcinoma | pubmed | 30714617 | Interaction between IGF2-PI3K axis and cancer-associated-fib... |
International journal of cancer | Wulfran Cacheux et al. | 2019 |
| IGF2 | - | IGF1R | IGF-1R | IGF2_IGF1R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Lung cancer cell | Human,Mouse | - | - | - | - | ABCB1 | Activation | IGF | Drug resistance | Inhibition | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 29383798 | Reverse of non-small cell lung cancer drug resistance induce... |
Cancer Science | Quanhui Zhang et al. | 2018 |
| IGFBP2 | - | ITGA5 | - | IGFBP2_ITGA5 | Ligand-receptor | Paracrine | Glial cell | Glioma cell | Glial cell | Glioma cell | Human,Mouse | - | - | - | - | MMP2,CDH5 | Activation | FAK/ERK | Vasculogenic mimicry formation | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 30368528 | IGFBP2 promotes vasculogenic mimicry formation via regulatin... |
Oncogene | Y Liu et al. | 2019 |
| IGFBP2 | - | ITGB1 | - | IGFBP2_ITGB1 | Ligand-receptor | Paracrine | Glial cell | Glioma cell | Glial cell | Glioma cell | Human,Mouse | - | - | - | - | MMP2,CDH5 | Activation | FAK/ERK | Vasculogenic mimicry formation | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 30368528 | IGFBP2 promotes vasculogenic mimicry formation via regulatin... |
Oncogene | Y Liu et al. | 2019 |
| IGSF11 | VSIG-3 | VSIR | VISTA | IGSF11_VSIR | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | T cell | T cell | Human,Mouse | - | - | - | - | - | - | VISTA | T cell production,Cytokine production | Inhibition,Activation | Liver | Blood | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30220083 | VSIG-3 as a ligand of VISTA inhibits human T-cell function | Immunology | Jinghua Wang et al. | 2019 |
| IGSF11 | VSIG-3 | VSIR | VISTA | IGSF11_VSIR | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | T cell | T cell | Human,Mouse | - | - | - | - | - | - | VISTA | T cell production,Cytokine production | Inhibition,Activation | Stomach | Blood | Malignant | Normal | - | - | - | - | Intestinal-type gastric cancer | Intestinal-type gastric cancer | pubmed | 30220083 | VSIG-3 as a ligand of VISTA inhibits human T-cell function | Immunology | Jinghua Wang et al. | 2019 |
| IL10 | - | IL10RA | - | IL10_IL10RA | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human | - | - | - | - | - | - | IL10 | Invasion,Metastasis | Activation,Activation | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30850734 | Gut microbiota-stimulated cathepsin K secretion mediates TLR... |
Cell death and differentiation | Rui Li et al. | 2019 |
| IL11 | - | IL11R | - | IL11_IL11R | Ligand-receptor | Paracrine | Malignant cell | Prostate cancer cell | Preosteoclast | Preosteoclast | Human,Mouse | - | - | - | - | - | - | IL11 | Osteoclastogenesis | Activation | Prostate | Bone | Malignant | Normal | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33731701 | Acetylation of KLF5 maintains EMT and tumorigenicity to caus... |
Nature communications | Baotong Zhang et al. | 2021 |
| Il11 | - | Il11ra | - | Il11_Il11ra | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | CXCL1,WNT4,CCL11 | Activation,Activation,Activation | IL11 | - | - | Liver | Liver | Normal | Normal | - | - | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 31398325 | Landscape of Intercellular Crosstalk in Healthy and NASH Liv... |
Molecular cell | Xuelian Xiong et al. | 2019 |
| Il11 | - | Il11ra | gp130+IL11RA | Il11_Il11ra | Ligand-receptor | Autocrine | Hepatocyte | Hepatocyte | Hepatocyte | Hepatocyte | Mouse | - | - | - | - | IL11 | Activation | IL6 | Cell death | Inhibition | Liver | Liver | Normal | Normal | Lipotoxic | Lipotoxic | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| Il11 | - | Il11ra | gp130+IL11RA | Il11_Il11ra | Ligand-receptor | Paracrine | Hepatocyte | Hepatocyte | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | IL11 | Activation | IL6 | - | - | Liver | Liver | Normal | Normal | Lipotoxic | - | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| Il11 | - | Il11ra | gp130+IL11RA | Il11_Il11ra | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | - | - | IL6 | Fibrosis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| Il11 | - | Il6st | gp130+IL11RA | Il11_Il6st | Ligand-receptor | Autocrine | Hepatocyte | Hepatocyte | Hepatocyte | Hepatocyte | Mouse | - | - | - | - | IL11 | Activation | IL6 | Cell death | Inhibition | Liver | Liver | Normal | Normal | Lipotoxic | Lipotoxic | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| Il11 | - | Il6st | gp130+IL11RA | Il11_Il6st | Ligand-receptor | Paracrine | Hepatocyte | Hepatocyte | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | IL11 | Activation | IL6 | - | - | Liver | Liver | Normal | Normal | Lipotoxic | - | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| Il11 | - | Il6st | gp130+IL11RA | Il11_Il6st | Ligand-receptor | Autocrine | Stellate cell | Hepatic stellate cell | Stellate cell | Hepatic stellate cell | Mouse | - | - | - | - | - | - | IL6 | Fibrosis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Non-alcoholic steatohepatitis (NASH) | Non-alcoholic steatohepatitis (NASH) | pubmed | 33397952 | Hepatocyte-specific IL11 cis-signaling drives lipotoxicity a... |
Nature communications | Feng Yang et al. | 2020 |
| IL13 | - | IL13RA1 | - | IL13_IL13RA1 | Ligand-receptor | Paracrine | Epithelial cell | Pancreatic intraepithelial neoplasia (PanIN) cell | Macrophage | Inflammatory macrophage | Human,Mouse | - | - | - | - | - | - | IL4 | Activated macrophages(M2) | Inhibition | Pancreas | Pancreas | Normal | Normal | - | - | - | M1 | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28514653 | The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio... |
Cell reports | Geou-YarhLiou et al. | 2017 |
| IL13 | - | IL13RA1 | - | IL13_IL13RA1 | Ligand-receptor | Paracrine | TUFT cell | TUFT cell | Macrophage | Inflammatory macrophage | Human,Mouse | - | - | - | - | - | - | IL4 | Activated macrophages(M2) | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | M1 | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28514653 | The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio... |
Cell reports | Geou-YarhLiou et al. | 2017 |
| IL13 | - | IL13RA1 | IL2rγ-IL13r⍺1 | IL13_IL13RA1 | Ligand-receptor | Paracrine | T cell | CD4+ Th2 cell | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | MYC | Activation | IL4 | Tumorigenesis,Proliferation,Tumor growth | Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | CD4+ TH2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 32046984 | Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ... |
Cancer Discovery | Prasenjit Dey et al. | 2020 |
| IL13 | - | IL2RG | IL2rγ-IL13r⍺1 | IL13_IL2RG | Ligand-receptor | Paracrine | T cell | CD4+ Th2 cell | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | MYC | Activation | IL4 | Tumorigenesis,Proliferation,Tumor growth | Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | CD4+ TH2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 32046984 | Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ... |
Cancer Discovery | Prasenjit Dey et al. | 2020 |
| IL15 | - | IL2RB | IL-2Rβ | IL15_IL2RB | Ligand-receptor | Paracrine | Dendritic cell | CCR7+ dendritic cell | T cell | Cytotoxic T lymphocyte | Human,Mouse | - | - | - | - | - | - | IL15 | Tumor regression | Inhibition | - | - | Normal | Normal | - | - | CCR7+ DC3 | Cytotoxic CD8+ | Melanoma | Melanoma | pubmed | 34343496 | CXCR6 positions cytotoxic T cells to receive critical surviv... |
Cell | Mauro Di Pilato et al. | 2021 |
| IL15RA | IL-15Rα | IL2RG | IL-2Rγ | IL15RA_IL2RG | Ligand-receptor | Paracrine | Dendritic cell | CCR7+ dendritic cell | T cell | Cytotoxic T lymphocyte | Human,Mouse | - | - | - | - | - | - | IL15RA | Tumor regression | Inhibition | - | - | Normal | Normal | - | - | CCR7+ DC3 | Cytotoxic CD8+ | Melanoma | Melanoma | pubmed | 34343496 | CXCR6 positions cytotoxic T cells to receive critical surviv... |
Cell | Mauro Di Pilato et al. | 2021 |
| IL17A | - | IL17RA | - | IL17A_IL17RA | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human | - | - | - | - | - | - | IL17 | Invasion,Metastasis | Activation,Activation | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30850734 | Gut microbiota-stimulated cathepsin K secretion mediates TLR... |
Cell death and differentiation | Rui Li et al. | 2019 |
| IL17A | - | IL17RA | - | IL17A_IL17RA | Ligand-receptor | Paracrine | Endothelial cell | Lymphatic endothelial cell | Cancer stem cell | CD133+ hepatoma stem cell | Human | - | - | - | - | CD274 | Activation | IL17A | Immune invasion,Self-renewal | Activation,Activation | Lymph | Liver | Normal | Malignant | - | - | - | CD133+ | Hepatoma | Hepatoma | pubmed | 31499129 | IL-17A secreted from lymphatic endothelial cells promotes tu... |
Journal of Hepatology | Yuanyan Wei et al. | 2019 |
| IL18 | - | IL18R | - | IL18_IL18R | Ligand-receptor | Paracrine | TAM | Myeloma-associated macrophage | Plasma cell | Multiple myeloma cell | Human,Mouse | - | - | - | - | - | - | IL18 | Bone destruction,Proliferation of MM cell | Activation,Activation | Bone marrow | Bone marrow | Cancer-associated | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 34289378 | β2-microglobulin triggers NLRP3 inflammasome activation in t... |
Immunity | Daniel Hofbauer et al. | 2021 |
| Il1a | - | Il1r1 | - | Il1a_Il1r1 | Ligand-receptor | Paracrine | Malignant cell | Metastasis-initiating breast cancer cell | CAF | Metastasis-associated fibroblast (MAF) | Mouse | - | - | - | - | CXCL9,CXCL10 | Activation | IL1 | - | - | Breast | Lung | Malignant | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| Il1a | - | Il1r1 | - | Il1a_Il1r1 | Ligand-receptor | Paracrine | Keratinocyte | Epidermal keratinocyte | Fibroblast | Dermal fibroblast | Mouse | Il1rn | Il1a antagonist | - | - | Cox2 | Activation | IL1 | Myofibroblast differentiation | Inhibition | Skin | Skin | Normal | Normal | - | - | - | - | - | - | pubmed | 30878678 | Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Ef... |
Journal of Investigative Dermatology | Rui Zheng et al. | 2019 |
| IL1A | - | IL1R1 | - | IL1A_IL1R1 | Ligand-receptor | Autocrine | Stellate cell | Pancreatic stellate cell | Stellate cell | Hepatic stellate cell | Human,Mouse | - | - | - | - | LIF | Activation | IL1 | Generate inflammatory CAF | Inhibition | Pancreas | Pancreas | Normal | Normal | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 30366930 | IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Sha... |
Cancer Discovery | Giulia Biffi et al. | 2019 |
| Il1a | - | Il1r1 | - | Il1a_Il1r1 | Ligand-receptor | Autocrine | Malignant cell | Metastasis-initiating breast cancer cell | Malignant cell | Metastasis-initiating breast cancer cell | Mouse | - | - | - | - | IL1A,IL1B | Activation | IL1 | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| IL1B | - | IL18R | - | IL1B_IL18R | Ligand-receptor | Paracrine | TAM | Myeloma-associated macrophage | Plasma cell | Multiple myeloma cell | Human,Mouse | - | - | - | - | - | - | IL1 | Bone destruction,Proliferation of MM cell | Activation,Activation | Bone marrow | Bone marrow | Cancer-associated | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 34289378 | β2-microglobulin triggers NLRP3 inflammasome activation in t... |
Immunity | Daniel Hofbauer et al. | 2021 |
| Il1b | - | Il1r1 | - | Il1b_Il1r1 | Ligand-receptor | Paracrine | Malignant cell | Metastasis-initiating breast cancer cell | CAF | Metastasis-associated fibroblast (MAF) | Mouse | - | - | - | - | CXCL9,CXCL10 | Activation | IL1 | - | - | Breast | Lung | Malignant | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| IL1B | - | IL1R1 | - | IL1B_IL1R1 | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Malignant cell | ER+ breast cancer cell | Human | - | - | - | - | - | - | IL1 | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 31419632 | Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance... |
iScience | Sumanta Chatterjee et al. | 2019 |
| IL1B | - | IL1R1 | - | IL1B_IL1R1 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Schwann cell | Schwann cell | Human,Mouse | - | - | - | - | IL6 | Activation | IL1 | - | - | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 32308766 | Tumor-neuroglia interaction promotes pancreatic cancer metas... |
Theranostics | Dan Su et al. | 2020 |
| Il1b | - | Il1r1 | - | Il1b_Il1r1 | Ligand-receptor | Autocrine | Malignant cell | Metastasis-initiating breast cancer cell | Malignant cell | Metastasis-initiating breast cancer cell | Mouse | - | - | - | - | IL1A,IL1B | Activation | IL1 | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32198421 | Metastasis-initiating cells induce and exploit a fibroblast ... |
Nature communications | Maren Pein et al. | 2020 |
| IL1B | IL-1β | IL1R1 | IL-1R | IL1B_IL1R1 | Ligand-receptor | Paracrine | Malignant cell | Oral squamous cell carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CXCL1,MMP1 | Activation,Activation | IL1B | Invasion,Migration | Activation,Activation | Oral | Oral | Malignant | Cancer-associated | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 30616781 | Reciprocal activation of cancer-associated fibroblasts and o... |
Oral Oncology | Ling-YingWei et al. | 2019 |
| IL1RN | - | IL1R1 | IL-1R | IL1RN_IL1R1 | Ligand-receptor | Paracrine | Macrophage | Alternatively activated macrophage | Epithelial cell | Pancreatic intraepithelial neoplasia (PanIN) cell | Human,Mouse | - | - | - | - | - | - | - | Pancreatic fibrogenesis,Tumorigenesis | Activation,Activation | Pancreas | Pancreas | Normal | Normal | - | - | M2 | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 28514653 | The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesio... |
Cell reports | Geou-YarhLiou et al. | 2017 |
| IL32 | - | ITGB3 | Integrin β3 | IL32_ITGB3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | FN1,CDH2,VIM | Activation,Activation,Activation | IL32 | EMT,Invasion,Metastasis | Activation,Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30391782 | Cancer-associated fibroblast(CAF)-derived IL32 promotes brea... |
Cancer letters | Siyang Wen et al. | 2019 |
| IL33 | - | IL1RAP | - | IL33_IL1RAP | Ligand-receptor | Paracrine | Perivascular cell | Perivascular cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | IL1 | Invasion,Metastasis | Activation,Activation | Blood | Pancreas | Normal | Cancer-associated | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| IL33 | - | IL1RAP | - | IL33_IL1RAP | Ligand-receptor | Paracrine | Fibroblast | Stromal fibroblast | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | IL1 | Invasion,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Cancer-associated | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| IL33 | - | IL1RL1 | - | IL33_IL1RL1 | Ligand-receptor | Paracrine | Perivascular cell | Perivascular cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | IL1 | Invasion,Metastasis | Activation,Activation | Blood | Pancreas | Normal | Cancer-associated | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| IL33 | - | IL1RL1 | - | IL33_IL1RL1 | Ligand-receptor | Paracrine | Fibroblast | Stromal fibroblast | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | IL1 | Invasion,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Cancer-associated | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| Il33 | - | Il1rl1 | - | Il33_Il1rl1 | Ligand-receptor | Paracrine | Cancer stem cell | Tumor-initiating cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | TGFB1 | Activation | IL33 | Differentiation | Inhibition | Skin | Skin | Malignant | Cancer-associated | - | - | - | FcεRIα+ | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 32675345 | Tumor-initiating cells establish an IL-33-TGF-β niche signal... |
Science | Sachiko Taniguchi et al. | 2020 |
| IL33 | IL-33 | IL1RL1 | ST2L | IL33_IL1RL1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | - | - | IL33 | EMT,Migration,Invasion,Metastasis | Activation,Activation,Activation,Activation | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 31659258 | The reciprocal interaction between tumor cells and activated... |
Oncogene | Quan Zhou et al. | 2020 |
| IL37 | - | IL37R | - | IL37_IL37R | Ligand-receptor | Paracrine | Malignant cell | Non small cell lung cancer cell | TAM | Tumor-conditioned macrophage | Human | - | - | - | - | MARCO | Activation | IL37 | Immune suppressive phenotype | Inhibition | Lung | Lung | Malignant | Cancer-associated | - | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 33293426 | Targeting MARCO and IL37R on Immunosuppressive Macrophages i... |
Cancer Research | Linnéa La Fleur et al. | 2021 |
| IL4 | - | IL2RG | IL2rγ-IL4r⍺ | IL4_IL2RG | Ligand-receptor | Paracrine | T cell | CD4+ Th2 cell | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | MYC | Activation | IL2 | Tumorigenesis,Proliferation,Tumor growth | Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | CD4+ TH2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 32046984 | Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ... |
Cancer Discovery | Prasenjit Dey et al. | 2020 |
| IL4 | - | IL4R | - | IL4_IL4R | Ligand-receptor | Autocrine | B cell | Chronic lymphocytic leukemia cell | B cell | Chronic lymphocytic leukemia cell | Human | - | - | - | - | JAG1,NOTCH1,NOTCH2 | Activation,Activation,Activation | IL4 | Tumor growth | Inhibition | Bone marrow | Bone marrow | Malignant | Malignant | - | - | - | - | Chronic lymphocytic leukemia (CLL) | Chronic lymphocytic leukemia (CLL) | pubmed | 30478302 | IL-4-dependent Jagged1 expression/processing is associated w... |
Cell death & disease | Filomena De Falco et al. | 2018 |
| IL4 | - | IL4R | - | IL4_IL4R | Ligand-receptor | Paracrine | Stem cell | Adipose-derived stem cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | DUSP4 | Inhibition | IL4 | Proliferation,Invasion,Stemness | Activation,Activation,Activation | Adipose | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28400477 | IL4 Primes the Dynamics of Breast Cancer Progression via DUS... |
Cancer Research | Miriam Gaggianesi et al. | 2017 |
| IL4 | - | IL4R | - | IL4_IL4R | Ligand-receptor | Paracrine | T cell | CD4+ helper T cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | DUSP4 | Inhibition | IL4 | Proliferation,Invasion,Stemness | Activation,Activation,Activation | Breast | Breast | Normal | Malignant | - | - | CD4+ | - | Breast Cancer | Breast Cancer | pubmed | 28400477 | IL4 Primes the Dynamics of Breast Cancer Progression via DUS... |
Cancer Research | Miriam Gaggianesi et al. | 2017 |
| IL4 | - | IL4R | IL2rγ-IL4r⍺ | IL4_IL4R | Ligand-receptor | Paracrine | T cell | CD4+ Th2 cell | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | MYC | Activation | IL2 | Tumorigenesis,Proliferation,Tumor growth | Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | CD4+ TH2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 32046984 | Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic ... |
Cancer Discovery | Prasenjit Dey et al. | 2020 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Myofibroblast | Bone marrow-derived myofibroblasts (BMFs) | Myofibroblast | Bone marrow-derived myofibroblasts (BMFs) | Human | - | - | - | - | - | - | IL6 | CSC-like cell | Inhibition | Bone marrow | Bone marrow | Normal | Normal | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 27109105 | Crosstalk between bone marrow-derived myofibroblasts and gas... |
Oncogene | Liming Zhu et al. | 2016 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Cancer stem cell | Glioma stem cell | Cancer stem cell | Glioma stem cell | Human | - | - | - | - | STAT3 | Activation | - | GSC characteristic | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 33576874 | Regulatory T cells promote glioma cell stemness through TGF-... |
Cancer Immunology, Immunotherapy | Shasha Liu et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Stem cell | Mesenchymal stem cell | Malignant cell | Osteosarcoma cell | Human,Mouse | - | - | - | - | - | - | STAT3 | Tumor growth,Metastasis | Activation,Activation | Bone | Bone | Normal | Malignant | - | - | - | - | Osteosarcoma | Osteosarcoma | pubmed | 28053020 | Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosa... |
Clinical cancer research | S. Rubina Baglio et al. | 2017 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | AKR1C3 | Activation | IL6 | Proliferation,Metastasis | Activation,Activation | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33361392 | A Positive Feedback Loop of AKR1C3-Mediated Activation of NF... |
Cancer Research | Qingqing Zhou et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Glial cell | Tumor cell | Glial cell | Tumor cell | Human,Mouse | - | - | - | - | - | - | IL6 | Tumor Progression | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 28724615 | Glioblastoma cellular cross-talk converges on NF-kB to atten... |
Genes & development | Ciro Zanca et al. | 2017 |
| IL6 | IL-6 | IL6R | IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | Tumor growth,Invasion | Activation,Activation | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30927911 | Targeting interleukin-6 as a strategy to overcome stroma-ind... |
Molecular cancer | In Hye Ham et al. | 2019 |
| IL6 | IL-6 | IL6R | IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | CAF | CD146-positive vascular cancer-associated fibroblast | Malignant cell | Intrahepatic cholangiocarcinoma cell | Human | - | - | - | - | EZH2 | Activation | IL6 | Stemness,Proliferation,Malignancy | Activation,Activation,Activation | Bile duct | Bile duct | Cancer-associated | Malignant | - | - | CD146+ | - | Intrahepatic cholangiocarcinoma (ICC) | Intrahepatic cholangiocarcinoma (ICC) | pubmed | 32505533 | Single-cell transcriptomic architecture and intercellular cr... |
Journal of hepatology | Min Zhang et al. | 2020 |
| IL6 | - | IL6R | IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | MET-unamplified gastric cancer cell | Human | - | - | - | - | TWIST1 | Activation | IL6 | Metastasis | Inhibition | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30158543 | HGF-mediated crosstalk between cancer-associated fibroblasts... |
Cell death & disease | Xusheng Ding et al. | 2018 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | miR-124 | Inhibition | IL6 | Invasion | Inhibition | Pancreas | Pancreas | Cancer-associated | Malignant | - | - | M2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33172931 | A Notch-Dependent Inflammatory Feedback Circuit between Macr... |
Cancer research | Yawen Geng et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Granulocyte | Granulocyte | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | Autophagy,Chemotherapy resistance | Activation,Activation | Colorectum | Colorectum | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 34131122 | IL-6 regulates autophagy and chemotherapy resistance by prom... |
Nature communications | Fuqing Hu et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | Autophagy,Chemotherapy resistance | Activation,Activation | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 34131122 | IL-6 regulates autophagy and chemotherapy resistance by prom... |
Nature communications | Fuqing Hu et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | Autophagy,Chemotherapy resistance | Activation,Activation | Colorectum | Colorectum | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 34131122 | IL-6 regulates autophagy and chemotherapy resistance by prom... |
Nature communications | Fuqing Hu et al. | 2021 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Malignant cell | Colorectal tumor cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | POSTN | Activation | IL6 | - | - | Colorectum | Colorectum | Malignant | Cancer-associated | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31968254 | Periostin Promotes Colorectal Tumorigenesis through Integrin... |
Cell reports | Handong Ma et al. | 2020 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | TEC | GBM-associated endothelial cell | TAM | GBM-associated macrophage | Human,Mouse | - | - | - | - | ARG1 | Activation | IL6 | Proliferation,Survival | Activation,Activation | Brain | Blood | Cancer-associated | Cancer-associated | - | - | - | M0 | Glioblastoma | Glioblastoma | pubmed | 29422647 | Vascular niche IL-6 induces alternative macrophage activatio... |
Nature communications | Qirui Wang et al. | 2018 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | FOXQ1,CCL2 | Activation,Activation | IL6 | Migration,Invasion,Metastasis | Activation,Activation,Activation | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30927925 | Crosstalk between cancer cells and tumor associated macropha... |
Molecular cancer | Chen Wei et al. | 2019 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | RTRAF | IL6 Agonist | - | - | - | - | IL6 | CSC,Metastasis | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28166202 | CGI-99 promotes breast cancer metastasis via autocrine inter... |
Oncogene | C Lin et al. | 2017 |
| IL6 | - | IL6R | IL-6R_GP130 | IL6_IL6R | Ligand-receptor | Paracrine | B cell | B cell | Malignant cell | Lung cancer cell | Human,Mouse | - | - | - | - | MUC16 | Activation | IL6 | EMT,Metastasis | Activation,Activation | Lung | Lung | Normal | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 33056994 | ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expre... |
Cell death & disease | Yuanyuan Lei et al. | 2020 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | - | - | MMP9,NANOG,SOX9 | Activation,Activation,Activation | IL6 | Migration,Invasion,Metastasis,Stemness | Activation,Activation,Activation,Activation | Ovary | Ovary | Cancer-associated | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 31212816 | Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasi... |
Cancers | Michelle K Y Siu et al. | 2019 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Schwann cell | Schwann cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | EMT,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 32308766 | Tumor-neuroglia interaction promotes pancreatic cancer metas... |
Theranostics | Dan Su et al. | 2020 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Malignant cell | HPV+ cervical cancer cell | Malignant cell | HPV positive cervical cancer cell | Human | - | - | - | - | STAT3 | Activation | IL6 | Proliferation,Survival | Activation,Activation | Cervix | Cervix | Malignant | Malignant | - | - | - | - | HPV positive cervical cancer | HPV positive cervical cancer | pubmed | 31226168 | Autocrine STAT3 activation in HPV positive cervical cancer t... |
PLoS pathogens | Ethan L. Morgan et al. | 2019 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | SREBP1,EIF4EBP1 | Activation,Inhibition | IL6 | Flammation,Tumorigenesis | Activation,Activation | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30523261 | An inflammatory-CCRK circuitry drives mTORC1-dependent metab... |
Nature communications | Hanyong Sun et al. | 2018 |
| IL6 | - | IL6R | - | IL6_IL6R | Ligand-receptor | Paracrine | Macrophage | Macrophage | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | NEK9 | Activation | IL6 | Metastasis | Inhibition | Stomach | Stomach | Normal | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 33500736 | NEK9, a novel effector of IL-6/STAT3, regulates metastasis o... |
Theranostics | Guofang Lu et al. | 2021 |
| IL6 | - | IL6R | IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Cancer cell | Human,Mouse | - | - | - | - | - | - | - | Migration,Invasion,Metastasis | Activation,Activation,Activation | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 31735641 | Cancer-Derived Succinate Promotes Macrophage Polarization an... |
Molecular Cell | Jing Yiing Wu et al. | 2020 |
| IL6 | IL-6 | IL6R | GP130/IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Prostate cancer cell | Human | - | - | - | - | - | - | IL6 | Tumorigenesis,Stemness,Invasion | Activation,Activation,Activation | Prostate | Prostate | Cancer-associated | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32066880 | MAOA-mediated reprogramming of stromal fibroblasts promotes ... |
Oncogene | Jingjing Li et al. | 2020 |
| IL6 | IL-6 | IL6R | IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Tumor cell | Human | - | - | - | - | CD274 | Activation | IL6 | Invasion | Inhibition | Thyroid | Thyroid | Cancer-associated | Malignant | - | - | - | - | Thyroid Cancer | Thyroid Cancer | pubmed | 33247999 | Interleukin 6 regulates the expression of programmed cell de... |
Cancer Sci | Guo-Qiang Zhang et al. | 2021 |
| IL6 | IL-6 | IL6R | IL-6Rα | IL6_IL6R | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Tumor cell | Human,Mouse | - | - | - | - | IL6 | Activation | IL6 | Proliferation,Apoptosis,Invasion,Tumor growth | Activation,Inhibition,Activation,Activation | Esophagus | Esophagus | Cancer-associated | Malignant | - | - | - | - | Esophageal squamous cell carcinoma | Esophageal squamous cell carcinoma | pubmed | 29976575 | IL-6 Mediates Cross-Talk between Tumor Cells and Activated F... |
Cancer research | Tatiana A Karakasheva et al. | 2018 |
| IL6 | IL-6 | IL6R | IL-6Rα | IL6_IL6R | Ligand-receptor | Autocrine | CAF | Cancer-associated Fibroblast | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | - | - | IL6 | Proliferation,Apoptosis,Invasion,Tumor growth | Activation,Inhibition,Activation,Activation | Esophagus | Esophagus | Cancer-associated | Cancer-associated | - | - | - | - | Esophageal Cancer | Esophageal Cancer | pubmed | 29976575 | IL-6 Mediates Cross-Talk between Tumor Cells and Activated F... |
Cancer research | Tatiana A Karakasheva et al. | 2018 |
| IL6 | IL-6 | IL6R | GP130/IL-6R | IL6_IL6R | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colon cancer cell | Human | - | - | - | - | - | - | IL6 | EMT,Migration,Invasion | Activation,Activation,Activation | Colon | Colon | Cancer-associated | Malignant | - | - | CD68+ | - | Colon Cancer | Colon Cancer | pubmed | 30243096 | PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through ... |
Biomedicine& Pharmacotherapy | Sikang Gao et al. | 2018 |
| Il6 | Obesity-induced interleukin-6 | Il6ra | - | Il6_Il6ra | Ligand-receptor | Paracrine | B cell | B cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | CCL20 | Activation | - | CAC progression | Inhibition | Stomach | Stomach | Normal | Cancer-associated | - | - | - | M2 | Colitis-associated colorectal cancer (CAC) | Colitis-associated colorectal cancer (CAC) | pubmed | 29695802 | Obesity exacerbates colitis-associated cancer via IL-6-regul... |
Nature communications | Claudia M Wunderlich et al. | 2018 |
| Il6 | IL-6 | Il6ra | IL-6 receptor | Il6_Il6ra | Ligand-receptor | Paracrine | Macrophage | Hepatic macrophage | Hepatocyte | Hepatocyte | Mouse | - | - | - | - | FOXM1 | Activation | IL6 | Proliferation | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | - | - | pubmed | 30546054 | Vagus-macrophage-hepatocyte link promotes post-injury liver ... |
Nature Communications | Tomohito Izumi et al. | 2018 |
| IL6 | - | IL6ST | - | IL6_IL6ST | Ligand-receptor | Autocrine | Glial cell | Tumor cell | Glial cell | Tumor cell | Human,Mouse | - | - | - | - | - | - | IL6 | Tumor Progression | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 28724615 | Glioblastoma cellular cross-talk converges on NF-kB to atten... |
Genes & development | Ciro Zanca et al. | 2017 |
| IL6 | - | IL6ST | IL-6R_GP130 | IL6_IL6ST | Ligand-receptor | Paracrine | B cell | B cell | Malignant cell | Lung cancer cell | Human,Mouse | - | - | - | - | MUC16 | Activation | IL6 | EMT,Metastasis | Activation,Activation | Lung | Lung | Normal | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 33056994 | ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expre... |
Cell death & disease | Yuanyuan Lei et al. | 2020 |
| IL6 | - | IL6ST | GP130 | IL6_IL6ST | Ligand-receptor | Paracrine | Fibroblast | Fibroblast | Malignant cell | ER+ breast cancer cell | Human | - | - | - | - | - | - | IL6 | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 31419632 | Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance... |
iScience | Sumanta Chatterjee et al. | 2019 |
| IL6 | - | IL6ST | - | IL6_IL6ST | Ligand-receptor | Paracrine | Schwann cell | Schwann cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | IL6 | EMT,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 32308766 | Tumor-neuroglia interaction promotes pancreatic cancer metas... |
Theranostics | Dan Su et al. | 2020 |
| IL6 | - | IL6ST | - | IL6_IL6ST | Ligand-receptor | Autocrine | Malignant cell | HPV+ cervical cancer cell | Malignant cell | HPV positive cervical cancer cell | Human | - | - | - | - | STAT3 | Activation | IL6 | Proliferation,Survival | Activation,Activation | Cervix | Cervix | Malignant | Malignant | - | - | - | - | HPV positive cervical cancer | HPV positive cervical cancer | pubmed | 31226168 | Autocrine STAT3 activation in HPV positive cervical cancer t... |
PLoS pathogens | Ethan L. Morgan et al. | 2019 |
| IL6 | - | IL6ST | - | IL6_IL6ST | Ligand-receptor | Paracrine | Macrophage | Macrophage | Malignant cell | Gastric cancer cell | Human,Mouse | - | - | - | - | NEK9 | Activation | IL6 | Metastasis | Inhibition | Stomach | Stomach | Normal | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 33500736 | NEK9, a novel effector of IL-6/STAT3, regulates metastasis o... |
Theranostics | Guofang Lu et al. | 2021 |
| IL6 | IL-6 | IL6ST | GP130/IL-6R | IL6_IL6ST | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Prostate cancer cell | Human | - | - | - | - | - | - | IL6 | Tumorigenesis,Stemness,Invasion | Activation,Activation,Activation | Prostate | Prostate | Cancer-associated | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32066880 | MAOA-mediated reprogramming of stromal fibroblasts promotes ... |
Oncogene | Jingjing Li et al. | 2020 |
| IL6 | IL-6 | IL6ST | GP130/IL-6R | IL6_IL6ST | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colon cancer cell | Human | - | - | - | - | - | - | IL6 | EMT,Migration,Invasion | Activation,Activation,Activation | Colon | Colon | Cancer-associated | Malignant | - | - | CD68+ | - | Colon Cancer | Colon Cancer | pubmed | 30243096 | PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through ... |
Biomedicine& Pharmacotherapy | Sikang Gao et al. | 2018 |
| Il7 | IL-7 | Il7r | IL-7R | Il7_Il7r | Ligand-receptor | Paracrine | Stromal cell | Bone marrow stromal cell | B cell | Pro B cell | Mouse | - | - | - | - | - | - | IL7 | - | - | Bone marrow | Bone marrow | Normal | Normal | - | - | - | Pro | - | - | pubmed | 30158115 | Cell circuits between B cell progenitors and IL-7+ mesenchym... |
Journal of Experimental Medicine | Chris Fistonich et al. | 2018 |
| INHBA | Activin A | ACVR1B | ActRIB | INHBA_ACVR1B | Ligand-receptor | Paracrine | Malignant cell | Cancer cell | Fibroblast | Fibroblast | Human,Mouse | - | - | - | - | DIAPH3 | Activation | ACTIVIN | Proliferation,Migration | Activation,Activation | Skin | Skin | Malignant | Normal | - | - | - | - | Skin Cancer | Skin Cancer | pubmed | 32150356 | A paracrine activin A–mDia2 axis promotes squamous carcinoge... |
EMBO Molecular Medicine | Michael Cangkrama et al. | 2020 |
| JAG1 | Jagged1 | NOTCH1 | - | JAG1_NOTCH1 | Ligand-receptor | Juxtacrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | - | - | NOTCH | Proliferation,Metastasis | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32943090 | Linc00514 promotes breast cancer metastasis and M2 polarizat... |
Journal of experimental & clinical cancer research : CR | Sifeng Tao et al. | 2020 |
| JAG1 | Jagged1 | NOTCH1 | Notch1 | JAG1_NOTCH1 | Ligand-receptor | Juxtacrine | Endothelial cell | Endothelial cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | VEGFA | Activation | NOTCH | Angiogenesis | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33046710 | Jagged1-Notch1-deployed tumor perivascular niche promotes br... |
Nature communications | Huimin Jiang et al. | 2020 |
| Lactate | - | Gpr132 | - | Lactate_Gpr132 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | VEGF | Activation | - | M2 polarization | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30180849 | NFE2L2 activation drive macrophages polarization and cancer ... |
Cell Communication and Signaling | Rui Feng et al. | 2018 |
| Lactate | - | Gpr132 | - | Lactate_Gpr132 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | VEGF | Activation | - | M2 polarization | Inhibition | Pancreas | Pancreas | Malignant | Cancer-associated | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 30180849 | NFE2L2 activation drive macrophages polarization and cancer ... |
Cell Communication and Signaling | Rui Feng et al. | 2018 |
| Lactate | - | Mct | - | Lactate_Mct | Ligand-receptor | Paracrine | Malignant cell | Colorectal cancer cell | Endothelial cell | Endothelial cell | Chicken,Mouse | - | - | - | - | - | - | - | Angiogenesis | Inhibition | Colon | Colon | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30867812 | Tumor-secreted dickkopf2 accelerates aerobic glycolysis and ... |
Theranostics | Fengliu Deng et al. | 2019 |
| LCN2 | - | SLC22A17 | LCN2R | LCN2_SLC22A17 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Endothelial cell | Lymphatic endothelial cell | Human | - | - | - | - | VEGFC | Activation | LCN2 | - | - | Breast | Lymph | Cancer-associated | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 27353364 | Lipocalin 2 from macrophages stimulated by tumor cell-derive... |
Science signaling | Michaela Jung et al. | 2016 |
| LEP | Leptin | LEPR | Ob-R | LEP_LEPR | Ligand-receptor | Paracrine | Adipocyte | - | Malignant cell | Breast cancer cell | Human | - | - | - | - | ACAT2 | Activation | PI3K | Proliferation,Migration,Invasion | Activation,Activation,Activation | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28770546 | Leptin promotes the migration and invasion of breast cancer ... |
Cellular Oncology | Yunxiu Huang et al. | 2017 |
| Lgals3 | Galectin 3 | Gp6 | Glycoprotein VI | Lgals3_Gp6 | Ligand-receptor | Juxtacrine | Malignant cell | Colorectal cancer cell | Platelet | Platelet | Mouse | - | - | - | - | EGF,PDGF,TGFB1 | Activation,Activation,Activation | GALECTIN | - | - | Colon | Blood | Malignant | Normal | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30305116 | Role of platelets and platelet receptors in cancer metastasi... |
Journal of hematology & oncology | Martin Schlesinger et al. | 2018 |
| Lgals3 | Galectin-3 | Gp6 | GPVI | Lgals3_Gp6 | Ligand-receptor | Juxtacrine | Malignant cell | Breast cancer cell | Platelet | Platelet | Mouse | - | - | - | - | - | - | GALECTIN | Metastasis | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 32040544 | Platelet glycoprotein VI promotes metastasis through interac... |
Blood | Elmina Mammadova-Bach et al. | 2020 |
| LGALS9 | Galactin-9 | VSIR | VISTA | LGALS9_VSIR | Ligand-receptor | Paracrine | Monocyte | Acute myeloid leukemia cell | T cell | T cell | Human | - | - | - | - | GZMB | Activation | GALECTIN | Apoptosis | Inhibition | Blood | Blood | Malignant | Normal | - | - | - | - | Acute myeloid leukemia (AML) | Acute myeloid leukemia (AML) | pubmed | 33329552 | Ligand-Receptor Interactions of Galectin-9 and VISTA Suppres... |
Frontiers in Immunology | Inna M. Yasinska et al. | 2020 |
| LGALS9 | Galactin-9 | VSIR | VISTA | LGALS9_VSIR | Ligand-receptor | Paracrine | Monocyte | Acute myeloid leukemia cell | T cell | T cell | Human | - | - | - | - | GZMB | Activation | GALECTIN | Apoptosis | Inhibition | Bone marrow | Blood | Malignant | Normal | - | - | - | - | Acute myeloid leukemia (AML) | Acute myeloid leukemia (AML) | pubmed | 33329552 | Ligand-Receptor Interactions of Galectin-9 and VISTA Suppres... |
Frontiers in Immunology | Inna M. Yasinska et al. | 2020 |
| LIF | - | IL6ST | - | LIF_IL6ST | Ligand-receptor | Paracrine | Stellate cell | Pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | LIFR | Tumor progression,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 30996350 | Targeting LIF-mediated paracrine interaction for pancreatic ... |
Nature | Yu Shi et al. | 2019 |
| LIF | - | IL6ST | LIFR_gp130 | LIF_IL6ST | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | LIFR | Metastasis | Inhibition | Bone marrow | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| LIF | - | LIFR | - | LIF_LIFR | Ligand-receptor | Paracrine | Stellate cell | Pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human,Mouse | - | - | - | - | - | - | LIFR | Tumor progression,Metastasis | Activation,Activation | Pancreas | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 30996350 | Targeting LIF-mediated paracrine interaction for pancreatic ... |
Nature | Yu Shi et al. | 2019 |
| LIF | - | LIFR | LIFR_gp130 | LIF_LIFR | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | LIFR | Metastasis | Inhibition | Bone marrow | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| LILRB2 | - | HLA-B | HLA-B | LILRB2_HLA-B | Ligand-receptor | Paracrine | Malignant cell | Lung adenocarcinoma cell | T cell | T cell | Human | - | - | - | - | - | - | - | Myeloid cell activation | Inhibition | Lung | Lung | Malignant | Normal | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 32549766 | Ligand-receptor interaction atlas within and between tumor c... |
International Journal of Biological Sciences | Zhencong Chen et al. | 2020 |
| Lipid | - | Cd36 | - | Lipid_Cd36 | Ligand-receptor | Paracrine | Adipocyte | Adipocyte | Malignant cell | Breast cancer cell | Mouse | - | - | - | - | CD36,FABP4 | Activation,Activation | CD36 | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33087562 | Blocking PPARγ interaction facilitates Nur77 interdiction of... |
Proceedings of the National Academy of Sciences of the Unite... |
Peng-Bo Yang et al. | 2020 |
| Lipid | - | Fabp4 | - | Lipid_Fabp4 | Ligand-receptor | Paracrine | Adipocyte | Adipocyte | Malignant cell | Breast cancer cell | Mouse | - | - | - | - | CD36,FABP4 | Activation,Activation | FABP4 | Proliferation | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33087562 | Blocking PPARγ interaction facilitates Nur77 interdiction of... |
Proceedings of the National Academy of Sciences of the Unite... |
Peng-Bo Yang et al. | 2020 |
| LOX | - | ITGB1 | β1 integrin | LOX_ITGB1 | Ligand-receptor | Paracrine | Glial cell | PTEN-deficient glioblastoma cell | Monocyte | Blood-derived monocyte | Human,Mouse | BAPN | LOX Antagonist | - | - | SPP1 | Activation | LOX | Survival,Angiogenesis | Activation,Activation | Brain | Blood vessel | Malignant | Normal | PTEN-deficient | - | - | - | Glioblastoma | Glioblastoma | pubmed | 31185211 | Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthet... |
Cancer cell | Peiwen Chen et al. | 2019 |
| LPA | - | LPAR | - | LPA_LPAR | Ligand-receptor | Paracrine | Malignant cell | Ovarian cancer cell | CAF | Cancer-associated Fibroblast | Human | - | - | - | - | αSMA | Activation | LPA | - | - | Ascites | Ascites | Malignant | Cancer-associated | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 30503552 | Ovarian Cancer Cell-derived Lysophosphatidic Acid Induces Gl... |
Cancer Letters | Rangasudhagar Radhakrishnan et al. | 2019 |
| LRP6N | LRP6 ectodomain | CXCR4 | SDF-1 | LRP6N_CXCR4 | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | - | - | LRP6N | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31010839 | LRP6 Ectodomain Prevents SDF-1/CXCR4-Induced Breast Cancer M... |
Clinical cancer research : an official journal of the Americ... |
Jiankang Zhang et al. | 2019 |
| LTA | Lymphotoxin-α | TNFRSF14 | - | LTA_TNFRSF14 | Ligand-receptor | Autocrine | Lymphocyte | Hodgkin/Reed-Sternberg cell | Lymphocyte | Hodgkin/Reed-Sternberg cell | Human | - | - | - | - | CD274,PDCD1LG2 | Activation,Activation | Lta | Immune invasion | Inhibition | Blood | Blood | Malignant | Malignant | - | - | - | - | Hodgkin lymphoma | Hodgkin lymphoma | pubmed | 30696620 | Autocrine LTA signaling drives NF-κB and JAK-STAT activity a... |
Blood | Linda von Hoff et al. | 2019 |
| Lta1 | LTα1β2 | Ltbr | LTβR | Lta1_Ltbr | Ligand-receptor | Paracrine | B cell | Eμ-Myc B-cell | Endothelial cell | Blood endothelial cell | Mouse | - | - | - | - | - | - | LT | Angiogenesis | Inhibition | Blood | Blood | Malignant | Normal | - | - | - | - | Lymphoma | Lymphoma | pubmed | 31932457 | Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signal... |
Cancer Research | Marleen Gloger et al. | 2020 |
| LTD4 | - | CYSLTR1 | CysLTR1 | LTD4_CYSLTR1 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Colon cancer cell | Human,Mouse | - | - | - | - | MMP9 | Activation | LTD4 | Invasion | Inhibition | Colon | Colon | Cancer-associated | Malignant | - | - | M2 | - | Colorectal Cancer | Colorectal Cancer | pubmed | 28098359 | M2-like macrophages induce colon cancer cell invasion via ma... |
Journal of cellular physiology | Katyayni Vinnakota et al. | 2017 |
| MBTPS1 | - | S1PR1 | - | MBTPS1_S1PR1 | Ligand-receptor | Paracrine | Malignant cell | Apoptotic tumor cell | TAM | Tumor-associated Macrophage | Human | - | - | - | - | LCN2 | Activation | S1P | - | - | Breast | Breast | Malignant | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 27353364 | Lipocalin 2 from macrophages stimulated by tumor cell-derive... |
Science signaling | Michaela Jung et al. | 2016 |
| MDK | Midkine | LRP1 | - | MDK_LRP1 | Ligand-receptor | Paracrine | Neuron | Nf1-mutant Retinal ganglion cell | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | CCL4 | Activation | MK | - | - | Brain | Brain | Normal | Normal | - | - | - | CD8+ | Glioma | Glioma | pubmed | 32358581 | Midkine activation of CD8 + T cells establishes a neuron-imm... |
Nature communications | Xiaofan Guo et al. | 2020 |
| Mdk | Midkine | Notch2 | - | Mdk_Notch2 | Ligand-receptor | Autocrine | Malignant cell | Non small cell lung cancer cell | Malignant cell | Non small cell lung cancer cell | Mouse | - | - | - | - | - | - | NOTCH2 | Tumor progression,Metastasis,Angiogenesis | Activation,Activation,Inhibition | Lung | Lung | Malignant | Malignant | Hypoxic | - | - | - | Non-small cell lung cancer | Non-small cell lung cancer | pubmed | 32847073 | Midkine Is a Potential Therapeutic Target of Tumorigenesis, ... |
Cancers | Dong Hoon Shin et al. | 2020 |
| NELL2 | - | ROBO3 | - | NELL2_ROBO3 | Ligand-receptor | Autocrine | Malignant cell | Ewing sarcoma cell | Malignant cell | Ewing sarcoma cell | Human,Mouse | - | - | - | - | BAF complex | Activation | NELL2 | Tumor growth | Inhibition | Bone | Bone | Malignant | Malignant | - | - | - | - | Ewing Sarcoma | Ewing Sarcoma | pubmed | 34233189 | NELL2-cdc42 signaling regulates BAF complexes and Ewing sarc... |
Cell Reports | Panneerselvam Jayabal et al. | 2021 |
| NGF | - | NTRK1 | TrkA | NGF_NTRK1 | Ligand-receptor | Paracrine | Neuron | Neuron | Malignant cell | Head and neck squamous cell carcinoma cell | Human | - | - | - | - | SNAI2,TWIST1 | Activation,Activation | NT | EMT | Inhibition | Head and neck | Head and neck | Normal | Malignant | - | - | - | - | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | pubmed | 31838083 | Nerve growth factor (NGF)-TrkA axis in head and neck squamou... |
Cancer letters | Chengzhong Lin et al. | 2020 |
| NRG1 | - | ERBB2 | - | NRG1_ERBB2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | Activation | PI3K | Tumor survival,Proliferation | Activation,Activation | Prostate | Prostate | Cancer-associated | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32679108 | Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Re... |
Cancer cell | Zeda Zhang et al. | 2020 |
| NRG1 | - | ERBB3 | - | NRG1_ERBB3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | Activation | PI3K | Tumor survival,Proliferation | Activation,Activation | Prostate | Prostate | Cancer-associated | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32679108 | Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Re... |
Cancer cell | Zeda Zhang et al. | 2020 |
| NRG1 | - | ERBB3 | HER3 | NRG1_ERBB3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Luminal breast cancer cell | Human | - | - | - | - | - | - | NRG1 | Proliferation,Migration | Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33692466 | Stromal NRG1 in luminal breast cancer defines pro-fibrotic a... |
Oncogene | Mireia Berdiel-Acer et al. | 2021 |
| NRG1 | - | ERBB3 | ErbB3 | NRG1_ERBB3 | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | JAG1 | Activation | NRG | Invasion,Intravasation | Activation,Activation | Breast | Breast | Malignant | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 29636067 | A novel neuregulin - jagged1 paracrine loop in breast cancer... |
Breast Cancer Research | Ramon M. Cabrera et al. | 2018 |
| NRG1 | - | ERBB4 | ErbB4 | NRG1_ERBB4 | Ligand-receptor | Paracrine | Endothelial cell | Endothelial cell | Cardiomyocyte | Cardiomyocyte | Human,Mouse | - | - | - | - | - | - | NRG | Cardiomyocyte growth | Inhibition | Heart | Heart | Normal | Normal | - | - | - | - | Cardiac Hypertrophy | Cardiac Hypertrophy | pubmed | 30922063 | Endothelial Cells Regulate Physiological Cardiomyocyte Growt... |
Circulation | Riikka Kivelä et al. | 2019 |
| OSM | - | IL6ST | OSMR_gp130 | OSM_IL6ST | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | OSM | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| OSM | - | IL6ST | LIFR_gp130 | OSM_IL6ST | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | OSM | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| OSM | - | LIFR | LIFR_gp130 | OSM_LIFR | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | OSM | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| OSM | - | OSMR | OSMR_gp130 | OSM_OSMR | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | SRC | Activation | OSM | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 34477239 | gp130 Cytokines Activate Novel Signaling Pathways and Alter ... |
Journal of Bone and Mineral Research | Tolu Omokehinde et al. | 2021 |
| Pdgf | - | Pdgfr | - | Pdgf_Pdgfr | Ligand-receptor | Paracrine | Platelet | Platelet | Malignant cell | Colorectal cancer cell | Mouse | - | - | - | - | PGE2 | Activation | PDGF | - | - | Blood | Colon | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 30305116 | Role of platelets and platelet receptors in cancer metastasi... |
Journal of hematology & oncology | Martin Schlesinger et al. | 2018 |
| PDGFB | PDGF-BB | PDGFRB | PDGFRβ | PDGFB_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Perivascular cell | Perivascular cell | Human,Mouse | - | - | - | - | IL33 | Activation | PDGF | Metastasis | Activation | Pancreas | Blood | Malignant | Normal | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| PDGFB | PDGF-BB | PDGFRB | PDGFRβ | PDGFB_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Fibroblast | Stromal fibroblast | Human,Mouse | - | - | - | - | IL33 | Activation | PDGF | Metastasis | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 27150562 | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and strom... |
Nature Communications | Yunlong Yang et al. | 2016 |
| PDGFB | PDGF-BB | PDGFRB | PDGFR-β | PDGFB_PDGFRB | Ligand-receptor | Paracrine | Cancer stem cell | Carcinoma associated mesenchymal stem/stromal cell | Cancer stem cell | Cancer stem-like cell | Human,Mouse | - | - | - | - | - | - | PDGF | Stemness,Platinum resistance,EMT | Activation,Activation,Activation | Ovary | Ovary | Malignant | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 32726910 | Carcinoma-Associated Mesenchymal Stem Cells Promote Chemores... |
Cancers | Shreya Raghavan et al. | 2020 |
| PDGFB | - | PDGFRB | - | PDGFB_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | Stellate cell | Hepatic stellate cell | Human,Mouse | - | - | - | - | HGF | Activation | PDGF | HSC activation | Inhibition | Liver | Liver | Malignant | Normal | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 31785057 | STMN1 upregulation mediates hapatocellular carcinoma and hep... |
Cancer science | Rui Zhang et al. | 2020 |
| PDGFB | - | PDGFRB | - | PDGFB_PDGFRB | Ligand-receptor | Autocrine | Malignant cell | Anoikis resistant cancer cell | Malignant cell | Anoikis resistant cancer cell | Human,Mouse | - | - | - | - | PDGFB | Activation | PDGF | Angiogenesis,Metastasis | Activation,Activation | Stomach | Stomach | Malignant | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 34341514 | Anoikis resistant gastric cancer cells promote angiogenesis ... |
Oncogene | Shangce Du et al. | 2021 |
| PDGFB | - | PDGFRB | - | PDGFB_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | Anoikis resistant gastric cancer cell | Endothelial cell | Vascular endothelial cell | Human,Mouse | - | - | - | - | - | - | PDGF | Angiogenesis,Metastasis | Activation,Activation | Stomach | Stomach | Malignant | Normal | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 34341514 | Anoikis resistant gastric cancer cells promote angiogenesis ... |
Oncogene | Shangce Du et al. | 2021 |
| PDGF-BB | - | PDGFRB | - | PDGF-BB_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | ER+ breast cancer cell | Fibroblast | Fibroblast | Human | - | - | - | - | IL1B | Activation | PDGF-BB | - | - | Breast | Breast | Malignant | Normal | - | - | - | - | ER+ breast cancer | ER+ breast cancer | pubmed | 31419632 | Paracrine Crosstalk between Fibroblasts and ER+ Breast Cance... |
iScience | Sumanta Chatterjee et al. | 2019 |
| PDGFC | - | PDGFRA | - | PDGFC_PDGFRA | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Gastrointestinal stromal tumor cell | Human | - | - | - | - | SLUG | Activation | PI3K | Proliferation,Migration,Invasion | Activation,Activation,Activation | Stomach | Stomach | Cancer-associated | Malignant | - | - | - | - | Gastrointestinal Stromal Tumors (GIST) | Gastrointestinal Stromal Tumors (GIST) | pubmed | 33603171 | Cancer-associated fibroblast secretion of PDGFC promotes gas... |
Oncogene | Hyunho Yoon et al. | 2021 |
| PDGFD | - | PDGFRB | - | PDGFD_PDGFRB | Ligand-receptor | Paracrine | Malignant cell | Cholangiocarcinoma cell | CAF | Cancer-associated Fibroblast | Human | - | - | - | - | VEGFC,VEGFA | Activation,Activation | PDGF | Lymphatic vasculature expansion,Tumor cell intravasation | Activation,Activation | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 30553841 | Platelet-derived growth factor-D enables liver myofibroblast... |
Journal of hepatology | Massimiliano Cadamuro et al. | 2019 |
| PGE2 | - | EGFR | - | PGE2_EGFR | Ligand-receptor | Paracrine | Glial cell | Tumor-activated enteric glial cell | Cancer stem cell | Colon cancer stem cell | Human,Mouse | - | - | - | - | - | - | PGE2 | Tumor growth | Inhibition | Colon | Colon | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31662289 | Tumor cells hijack enteric glia to activate colon cancer ste... |
EBioMedicine | Simon Valès et al. | 2019 |
| Pge2 | - | Nr4a1 | Nur77 | Pge2_Nr4a1 | Ligand-receptor | Paracrine | Malignant cell | Prostate cancer cell | Stromal cell | Stromal cell | Mouse | - | - | - | - | PRL | Activation | PGE2 | - | - | Prostate | Prostate | Malignant | Normal | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 30819896 | Cox-2 mediates tumor-stromal prolactin signaling to initiate... |
Proceedings of the National Academy of Sciences of the Unite... |
Yu Zheng et al. | 2019 |
| PGE2 | - | PTGER4 | EP4 | PGE2_PTGER4 | Ligand-receptor | Paracrine | Glial cell | Tumor-activated enteric glial cell | Cancer stem cell | Colon cancer stem cell | Human,Mouse | - | - | - | - | - | - | PGE2 | Tumorigenesis,Tumor growth | Activation,Activation | Colon | Colon | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31662289 | Tumor cells hijack enteric glia to activate colon cancer ste... |
EBioMedicine | Simon Valès et al. | 2019 |
| PGE2 | - | PTGER4 | - | PGE2_PTGER4 | Ligand-receptor | Paracrine | Stellate cell | Hepatic stellate cell | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | - | - | - | Anti-tumor immunity | Inhibition | Liver | Liver | Normal | Normal | - | - | - | CD8+ | Obesity-Associated Liver Cancer | Obesity-Associated Liver Cancer | pubmed | 28202625 | Gut Microbiota Promotes Obesity-Associated Liver Cancer thro... |
Cancer Discovery | Tze Mun Loo et al. | 2017 |
| PGE2 | - | PTGER4 | - | PGE2_PTGER4 | Ligand-receptor | Paracrine | Stellate cell | Hepatic stellate cell | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | - | - | - | Anti-tumor immunity | Inhibition | Liver | Liver | Normal | Normal | - | - | - | CD8+ | Obesity-Associated Liver Cancer | Obesity-Associated Liver Cancer | pubmed | 28202625 | Gut Microbiota Promotes Obesity-Associated Liver Cancer thro... |
Cancer Discovery | Tze Mun Loo et al. | 2017 |
| PGE2 | - | PTGER4 | Ptger4 | PGE2_PTGER4 | Ligand-receptor | Paracrine | Fibroblast | Ptgs2-expressing fibroblast | Cancer stem cell | Tumour-initiating stem cell | Human,Mouse | - | - | - | - | - | - | PGE2 | Tumorigenesis | Inhibition | Colon | Colon | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 32322056 | Paracrine orchestration of intestinal tumorigenesis by a mes... |
Nature | Manolis Roulis et al. | 2020 |
| PGE2 | - | PTGER5 | EP4 | PGE2_PTGER5 | Ligand-receptor | Autocrine | Malignant cell | Tumor cell | Malignant cell | Tumor cell | Human | - | - | - | - | VEGFA,VEGFC,VEGFD | Activation,Activation,Activation | PGE2 | Proliferation | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31277414 | Mir526b and Mir655 promote Tumor Associated Angiogenesis and... |
Cansers | Stephanie Hunter et al. | 2019 |
| PGF | PIGE | FLT1 | VEGFR1 | PGF_FLT1 | Ligand-receptor | Paracrine | Cardiomyocyte | Cardiomyocyte | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | - | - | VEGF | Cardiomyocyte growth | - | Heart | Heart | Normal | Normal | - | - | - | - | Cardiac Hypertrophy | Cardiac Hypertrophy | pubmed | 30922063 | Endothelial Cells Regulate Physiological Cardiomyocyte Growt... |
Circulation | Riikka Kivelä et al. | 2019 |
| Plau | uPA | Plaur | uPAR | Plau_Plaur | Ligand-receptor | Autocrine | Malignant cell | Keratinocyte | Malignant cell | Keratinocyte | Mouse | - | - | - | - | - | - | PLAU | Basal cell carcinoma formation | Inhibition | Skin | Skin | Malignant | Malignant | - | - | - | - | Basal cell carcinoma | Basal cell carcinoma | pubmed | 30291846 | Overexpression of Desmoglein 2 in a Mouse model of Gorlin Sy... |
The Journal of investigative dermatology | Donna M Brennan-Crispi et al. | 2019 |
| Polyunsaturated fatty acid | - | Pparg | PPARγ | Polyunsaturated fatty acid_Pparg | Ligand-receptor | Paracrine | Astrocyte | Astrocyte | Malignant cell | Brain metastatic cancer cell | Mouse | - | - | - | - | - | - | PPARG | Brain metastasis | Inhibition | Brain | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 31578185 | Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ S... |
Cancer Discovery | Yongkang Zou et al. | 2019 |
| POSTN | Periostin | ITGAV | - | POSTN_ITGAV | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | IL6 | Activation | PERIOSTIN | Tumorigenesis | Inhibition | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31968254 | Periostin Promotes Colorectal Tumorigenesis through Integrin... |
Cell reports | Handong Ma et al. | 2020 |
| POSTN | Periostin | ITGAV | - | POSTN_ITGAV | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | IL6 | Activation | PERIOSTIN | Tumorigenesis | Inhibition | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31968254 | Periostin Promotes Colorectal Tumorigenesis through Integrin... |
Cell reports | Handong Ma et al. | 2020 |
| POSTN | Periostin | ITGAV | Integrin αvβ3 | POSTN_ITGAV | Ligand-receptor | Paracrine | Stromal cell | Bone marrow-derived mesenchymal stromal cell | Lymphocyte | B cell acute lymphoblastic leukemia cell | Human,Mouse | - | - | - | - | CCL2 | Activation | Postn | Proliferation,Progression | Activation,Activation | Bone marrow | Blood | Normal | Malignant | - | - | - | - | B cell acute lymphoblastic leukemia | B cell acute lymphoblastic leukemia | pubmed | 30726736 | Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo... |
Cell Reports | Zhenling Ma et al. | 2019 |
| POSTN | Periostin | ITGAV | Integrin αvβ5 | POSTN_ITGAV | Ligand-receptor | Paracrine | Stromal cell | Bone marrow-derived mesenchymal stromal cell | Lymphocyte | B cell acute lymphoblastic leukemia cell | Human,Mouse | - | - | - | - | CCL2 | Activation | Postn | Proliferation,Progression | Activation,Activation | Bone marrow | Blood | Normal | Malignant | - | - | - | - | B cell acute lymphoblastic leukemia | B cell acute lymphoblastic leukemia | pubmed | 30726736 | Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo... |
Cell Reports | Zhenling Ma et al. | 2019 |
| POSTN | Periostin | ITGB3 | - | POSTN_ITGB3 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | IL6 | Activation | PERIOSTIN | Tumorigenesis | Inhibition | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31968254 | Periostin Promotes Colorectal Tumorigenesis through Integrin... |
Cell reports | Handong Ma et al. | 2020 |
| POSTN | Periostin | ITGB3 | Integrin αvβ3 | POSTN_ITGB3 | Ligand-receptor | Paracrine | Stromal cell | Bone marrow-derived mesenchymal stromal cell | Lymphocyte | B cell acute lymphoblastic leukemia cell | Human,Mouse | - | - | - | - | CCL2 | Activation | Postn | Proliferation,Progression | Activation,Activation | Bone marrow | Blood | Normal | Malignant | - | - | - | - | B cell acute lymphoblastic leukemia | B cell acute lymphoblastic leukemia | pubmed | 30726736 | Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo... |
Cell Reports | Zhenling Ma et al. | 2019 |
| POSTN | Periostin | ITGB5 | - | POSTN_ITGB5 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Colorectal cancer cell | Human,Mouse | - | - | - | - | IL6 | Activation | PERIOSTIN | Tumorigenesis | Inhibition | Colorectum | Colorectum | Cancer-associated | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 31968254 | Periostin Promotes Colorectal Tumorigenesis through Integrin... |
Cell reports | Handong Ma et al. | 2020 |
| POSTN | Periostin | ITGB5 | Integrin αvβ5 | POSTN_ITGB5 | Ligand-receptor | Paracrine | Stromal cell | Bone marrow-derived mesenchymal stromal cell | Lymphocyte | B cell acute lymphoblastic leukemia cell | Human,Mouse | - | - | - | - | CCL2 | Activation | Postn | Proliferation,Progression | Activation,Activation | Bone marrow | Blood | Normal | Malignant | - | - | - | - | B cell acute lymphoblastic leukemia | B cell acute lymphoblastic leukemia | pubmed | 30726736 | Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promo... |
Cell Reports | Zhenling Ma et al. | 2019 |
| POSTN | - | LRP6 | - | POSTN_LRP6 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Cancer cell | Human,Mouse | - | - | - | - | - | - | PTK7 | Proliferation,Invasion | Activation,Activation | Tongue | Tongue | Cancer-associated | Malignant | - | - | - | - | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | pubmed | 30348980 | Periostin secreted by cancer-associated fibroblasts promotes... |
Cell Death Disease | Binbin Yu et al. | 2018 |
| POSTN | - | PTK7 | - | POSTN_PTK7 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Cancer cell | Human,Mouse | - | - | - | - | - | - | PTK7 | Proliferation,Invasion | Activation,Activation | Tongue | Tongue | Cancer-associated | Malignant | - | - | - | - | Head and neck squamous cell carcinoma | Head and neck squamous cell carcinoma | pubmed | 30348980 | Periostin secreted by cancer-associated fibroblasts promotes... |
Cell Death Disease | Binbin Yu et al. | 2018 |
| Prl | - | Prlr | - | Prl_Prlr | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | Prostate cancer cell | Mouse | - | - | - | - | - | - | PRL | Metastasis | Inhibition | Prostate | Prostate | Normal | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 30819896 | Cox-2 mediates tumor-stromal prolactin signaling to initiate... |
Proceedings of the National Academy of Sciences of the Unite... |
Yu Zheng et al. | 2019 |
| Pros1 | - | Mertk | - | Pros1_Mertk | Ligand-receptor | Paracrine | Macrophage | Bone marrow derived Macrophage | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | IL10 | Inhibition | PROS1 | - | - | Lung | Lung | Normal | Cancer-associated | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33848267 | Myeloid cell-derived PROS1 inhibits tumor metastasis by regu... |
The Journal of Clinical Investigation | Avi Maimon et al. | 2021 |
| Pros1 | - | Mertk | - | Pros1_Mertk | Ligand-receptor | Paracrine | Macrophage | Bone marrow derived Macrophage | TAM | Tumor-associated Macrophage | Mouse | - | - | - | - | IL10 | Inhibition | PROS1 | - | - | Lung | Lung | Normal | Cancer-associated | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 33848267 | Myeloid cell-derived PROS1 inhibits tumor metastasis by regu... |
The Journal of Clinical Investigation | Avi Maimon et al. | 2021 |
| PTX3 | - | TLR4 | - | PTX3_TLR4 | Ligand-receptor | Autocrine | Melanocyte | Melanocyte | Melanocyte | Melanocyte | Human,Mouse | - | - | - | - | - | - | PTX3 | Induced melanoma cell migration | Inhibition | Skin | Skin | Malignant | Malignant | - | - | - | - | Cutaneous melanoma | Cutaneous melanoma | pubmed | 31253871 | Cancer cell-derived long pentraxin 3 (PTX3) promotes melanom... |
Oncogene | M Rathore et al. | 2019 |
| Retn | - | Tlr4 | - | Retn_Tlr4 | Ligand-receptor | Paracrine | Adipocyte | Adipocyte | Malignant cell | Breast cancer cell | Mouse | - | - | - | - | - | - | RESISTIN | Proliferation,Stemness | Activation,Activation | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33318171 | Adipocytes promote breast tumorigenesis through TAZ-dependen... |
Proceedings of the National Academy of Sciences of the Unite... |
Yuhao Gao et al. | 2020 |
| Rnase1 | hRNase 1 | Epha4 | EphA4 | Rnase1_Epha4 | Ligand-receptor | Paracrine | Cancer stem cell | Breast CSC-like cell | Cancer stem cell | Breast CSC-like cell | Mouse | - | - | - | - | RNASE1 | Activation | EPHA4 | Tumor initiating capability,Tumorigenesis | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast tumor | Breast tumor | pubmed | 33986289 | Human ribonuclease 1 serves as a secretory ligand of ephrin ... |
Nature communications | Heng-Huan Lee et al. | 2021 |
| Rnase1 | hRNase 1 | Epha4 | EphA4 | Rnase1_Epha4 | Ligand-receptor | Autocrine | Cancer stem cell | Breast CSC-like cell | Cancer stem cell | Breast CSC-like cell | Mouse | - | - | - | - | RNASE1 | Activation | EPHA4 | Tumor initiating capability,Tumorigenesis | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast tumor | Breast tumor | pubmed | 33986289 | Human ribonuclease 1 serves as a secretory ligand of ephrin ... |
Nature communications | Heng-Huan Lee et al. | 2021 |
| RSPO1 | R-spondin | LGR4 | - | RSPO1_LGR4 | Ligand-receptor | Paracrine | Osteoblast | Nichte cell/(pre)osteoblast | B cell | Multiple myeloma cell | Human | - | - | - | - | WNT | Activation | RSPO | Proliferation | Inhibition | Bone marrow | Bone marrow | Normal | Malignant | - | - | - | - | Multiple Myeloma | Multiple Myeloma | pubmed | 28028233 | Aberrantly expressed LGR4 empowers Wnt signaling in multiple... |
Proceedings of the National Academy of Sciences of the Unite... |
Harmen van Andel et al. | 2017 |
| Rspo1 | Rspo1 | Lgr4 | Lgr4 | Rspo1_Lgr4 | Ligand-receptor | Paracrine | Mesenchymal cell | Nonmyofibroblastic CD34+ Gp38+ mesenchymal cell | Stem cell | Intestinal epithelial stem cell | Mouse | - | - | - | - | - | - | RSPO1 | Proliferation | Inhibition | Ileum | Ileum | Normal | Normal | - | - | - | - | Intestinal inflammation | Intestinal inflammation | pubmed | 28074039 | CD34+ mesenchymal cells are a major component of the intesti... |
Proceedings of the National Academy of Sciences of the Unite... |
Igor Stzepourginski et al. | 2017 |
| Rspo1 | Rspo1 | Lgr4 | Lgr4 | Rspo1_Lgr4 | Ligand-receptor | Paracrine | Mesenchymal cell | Nonmyofibroblastic CD34+ Gp38+ mesenchymal cell | Stem cell | Intestinal epithelial stem cell | Mouse | - | - | - | - | - | - | RSPO1 | Proliferation | Inhibition | Colon | Colon | Normal | Normal | - | - | - | - | Intestinal inflammation | Intestinal inflammation | pubmed | 28074039 | CD34+ mesenchymal cells are a major component of the intesti... |
Proceedings of the National Academy of Sciences of the Unite... |
Igor Stzepourginski et al. | 2017 |
| Rspo1 | Rspo1 | Lgr5 | Lgr5 | Rspo1_Lgr5 | Ligand-receptor | Paracrine | Mesenchymal cell | Nonmyofibroblastic CD34+ Gp38+ mesenchymal cell | Stem cell | Intestinal epithelial stem cell | Mouse | - | - | - | - | - | - | RSPO1 | Proliferation | Inhibition | Ileum | Ileum | Normal | Normal | - | - | - | - | Intestinal inflammation | Intestinal inflammation | pubmed | 28074039 | CD34+ mesenchymal cells are a major component of the intesti... |
Proceedings of the National Academy of Sciences of the Unite... |
Igor Stzepourginski et al. | 2017 |
| Rspo1 | Rspo1 | Lgr5 | Lgr5 | Rspo1_Lgr5 | Ligand-receptor | Paracrine | Mesenchymal cell | Nonmyofibroblastic CD34+ Gp38+ mesenchymal cell | Stem cell | Intestinal epithelial stem cell | Mouse | - | - | - | - | - | - | RSPO1 | Proliferation | Inhibition | Colon | Colon | Normal | Normal | - | - | - | - | Intestinal inflammation | Intestinal inflammation | pubmed | 28074039 | CD34+ mesenchymal cells are a major component of the intesti... |
Proceedings of the National Academy of Sciences of the Unite... |
Igor Stzepourginski et al. | 2017 |
| S100A9 | - | AGER | - | S100A9_AGER | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Hepatocellular carcinoma cell | Human | - | - | - | - | Stemness related gene,CCL2 | Activation,Activation | AGER | Metastasis,Tumor growth | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33205453 | S100 calcium-binding protein A9 from tumor-associated macrop... |
International journal of cancer | Ran Wei et al. | 2021 |
| SEMA3C | - | NRP1 | - | SEMA3C_NRP1 | Ligand-receptor | Paracrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | - | SEMA3 | Perineural invasion | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33420365 | MAOA promotes prostate cancer cell perineural invasion throu... |
Oncogene | Lijuan Yin et al. | 2021 |
| SEMA3C | - | NRP1 | - | SEMA3C_NRP1 | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | - | SEMA3 | Perineural invasion | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33420365 | MAOA promotes prostate cancer cell perineural invasion throu... |
Oncogene | Lijuan Yin et al. | 2021 |
| SEMA3C | - | PLXNA2 | - | SEMA3C_PLXNA2 | Ligand-receptor | Paracrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | - | SEMA3 | Perineural invasion | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33420365 | MAOA promotes prostate cancer cell perineural invasion throu... |
Oncogene | Lijuan Yin et al. | 2021 |
| SEMA3C | - | PLXNA2 | - | SEMA3C_PLXNA2 | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | - | SEMA3 | Perineural invasion | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33420365 | MAOA promotes prostate cancer cell perineural invasion throu... |
Oncogene | Lijuan Yin et al. | 2021 |
| SEMA3C | - | PLXNA2 | - | SEMA3C_PLXNA2 | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | - | - | SEMA3 | Perineural invasion | Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33420365 | MAOA promotes prostate cancer cell perineural invasion throu... |
Oncogene | Lijuan Yin et al. | 2021 |
| Sema3d | - | Nrp1 | - | Sema3d_Nrp1 | Ligand-receptor | Autocrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Mouse | - | - | - | - | - | - | PLXND1 | Progression,Metastasis | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31163177 | Axon Guidance Molecules Promote Perineural Invasion and Meta... |
Gastroenterology | Noelle R Jurcak et al. | 2019 |
| Sema3d | - | Nrp1 | - | Sema3d_Nrp1 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Neuron | Dorsal root ganglion cell | Mouse | - | - | - | - | - | - | PLXND1 | Perineural invasion | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31163177 | Axon Guidance Molecules Promote Perineural Invasion and Meta... |
Gastroenterology | Noelle R Jurcak et al. | 2019 |
| Sema3d | - | Plxnd1 | - | Sema3d_Plxnd1 | Ligand-receptor | Autocrine | Malignant cell | Pancreatic cancer cell | Malignant cell | Pancreatic cancer cell | Mouse | - | - | - | - | - | - | PLXND1 | Progression,Metastasis | Activation,Activation | Pancreas | Pancreas | Malignant | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31163177 | Axon Guidance Molecules Promote Perineural Invasion and Meta... |
Gastroenterology | Noelle R Jurcak et al. | 2019 |
| SERPINE1 | PAI-1 | LRP1 | - | SERPINE1_LRP1 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic cancer cell | Stellate cell | Pancreatic stellate cell | Human | KRAS | SERPINE1 Agonist | - | - | IL8 | Activation | LRP1 | Fibrosis | Inhibition | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 31695760 | Pancreatic stellate cells activated by mutant KRAS-mediated ... |
Theranostics | Hao-Chen Wang et al. | 2019 |
| Shh | - | Ptch1 | - | Shh_Ptch1 | Ligand-receptor | Paracrine | Melanocyte | Melanocyte | CAF | Tumor-associated Fibroblast | Mouse | - | - | - | - | VEGF | Activation | Shh | Endothelial cell proliferation,Angiogenesis | Activation,Activation | Skin | Skin | Malignant | Cancer-associated | - | - | - | - | Melanoma | Melanoma | pubmed | 28127049 | Hhip regulates tumor-stroma-mediated upregulation of tumor a... |
Experimental & molecular medicine | Vijayendra Agrawal et al. | 2017 |
| Shh | - | Ptch1 | - | Shh_Ptch1 | Ligand-receptor | Paracrine | Malignant cell | Prostate cancer cell | Osteoblast | Osteoblast | Mouse | - | - | - | - | IL6 | Activation | HH | Metastasis | Inhibition | Prostate | Bone | Malignant | Normal | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 28292438 | MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network... |
Cancer cell | Jason Boyang Wu et al. | 2017 |
| SHH | - | PTCH1 | PTCH | SHH_PTCH1 | Ligand-receptor | Paracrine | Malignant cell | Lung adenocarcinoma cell | Stromal cell | Stromal cell | Human,Mouse | - | - | - | - | VEGFA | Activation | HH | - | - | Lung | Lung | Malignant | Normal | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 28368412 | Noncanonical GLI1 signaling promotes stemness features and i... |
Oncogene | A Po et al. | 2017 |
| SIRPA | - | CD47 | - | SIRPA_CD47 | Ligand-receptor | Juxtacrine | Macrophage | Macrophage | Malignant cell | Colon cancer cell | Human,Mouse | - | - | - | - | - | - | MAPK | Proliferation,Migration | Activation,Activation | Colon | Colon | Normal | Malignant | - | - | - | - | Colorectal Cancer | Colorectal Cancer | pubmed | 32226539 | Tumor-intrinsic CD47 signal regulates glycolysis and promote... |
Theranostics | Tuo Hu et al. | 2020 |
| Sirpa | - | Cd47 | - | Sirpa_Cd47 | Ligand-receptor | Juxtacrine | Macrophage | Macrophage | Malignant cell | Triple Negative Breast Cancer cell | Mouse | - | - | - | - | - | - | SIRPA | Innate immunity | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 29367423 | Chemotherapy induces enrichment of CD47+/CD73+/ PDL1+ immune... |
Proceedings of the National Academy of Sciences of the Unite... |
Debangshu Samanta et al. | 2018 |
| Sirpa | SIRPα | Cd47 | - | Sirpa_Cd47 | Ligand-receptor | Juxtacrine | TAM | Tumor-associated Macrophage | Malignant cell | Cancer cell | Mouse | - | - | - | - | - | - | SIRPA | Phagocytosis | Inhibition | Skin | Skin | Cancer-associated | Malignant | - | - | M2 | - | Melanoma | Melanoma | pubmed | 31659802 | CSF1R- and SHP2-Inhibitor-Loaded Nanoparticles Enhance Cytot... |
Advanced materials | Anujan Ramesh et al. | 2019 |
| SPINK1 | - | EGFR | - | SPINK1_EGFR | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | Cancer cell | Human | - | - | - | - | TWIST1,SNAIL1 | Activation | EGFR | EMT,Chemoresistance | Activation,Activation | Prostate | Prostate | Normal | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 30333494 | Targeting SPINK1 in the damaged tumour microenvironment alle... |
Nature communications | Fei Chen et al. | 2018 |
| SPP1 | OPN(osteopontin) | CD44 | - | SPP1_CD44 | Ligand-receptor | Paracrine | Mesothelial cell | Cancer-associated mesothelial cell | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | - | - | - | - | SPP1 | Cancer stemness,Chemoresistance,Tumorigenesis | Activation,Activation,Activation | Ovary | Ovary | Malignant | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34396988 | Cancer-associated mesothelial cells promote ovarian cancer c... |
The Journal of clinical investigation | Jin Qian et al. | 2021 |
| SPP1 | OPN(osteopontin) | CD44 | - | SPP1_CD44 | Ligand-receptor | Paracrine | Mesothelial cell | Cancer-associated mesothelial cell | Malignant cell | Ovarian cancer cell | Human,Mouse | - | - | - | - | - | - | SPP1 | Cancer stemness,Chemoresistance,Tumorigenesis | Activation,Activation,Activation | Ovary | Ovary | Malignant | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34396988 | Cancer-associated mesothelial cells promote ovarian cancer c... |
The Journal of clinical investigation | Jin Qian et al. | 2021 |
| Spp1 | Opn | Itga4 | - | Spp1_Itga4 | Ligand-receptor | Paracrine | Macrophage | Macrophage | Macrophage | Macrophage | Mouse | - | - | - | - | CD163 | Activation | SPP1 | Angiogenesis | Inhibition | Ascites | Blood | Normal | Normal | - | - | - | - | Rheumatoid arthritis | Rheumatoid arthritis | pubmed | 29559970 | Interleukin-18 Amplifies Macrophage Polarization and Morphol... |
Frontiers in Immunology | Takuro Kobori et al. | 2018 |
| SPP1 | OPN | ITGAV | Integrin AlphaVbeta3 | SPP1_ITGAV | Ligand-receptor | Paracrine | Stellate cell | Pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | FOXM1 | Activation | SPP1 | EMT,Invasion,Metastasis,Chemoresistance | Activation,Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | Hypoxia | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 30367545 | Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling... |
Molecular oncology | Junyu Cao et al. | 2018 |
| SPP1 | OPN | ITGB3 | Integrin AlphaVbeta3 | SPP1_ITGB3 | Ligand-receptor | Paracrine | Stellate cell | Pancreatic stellate cell | Malignant cell | Pancreatic cancer cell | Human | - | - | - | - | FOXM1 | Activation | SPP1 | EMT,Invasion,Metastasis,Chemoresistance | Activation,Activation,Activation,Activation | Pancreas | Pancreas | Normal | Malignant | Hypoxia | - | - | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 30367545 | Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling... |
Molecular oncology | Junyu Cao et al. | 2018 |
| SRGN | - | CD44 | - | SRGN_CD44 | Ligand-receptor | Autocrine | Malignant cell | Triple-negative breast cancer cell | Malignant cell | Triple Negative Breast Cancer cell | Human | - | - | - | - | CREB1 | Activation | SPP1 | EMT | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 28692037 | SRGN-TGFß2 regulatory loop confers invasion and metastasis i... |
Oncogenesis | Z Zhang et al. | 2017 |
| Succinate | - | SUCNR1 | - | Succinate_SUCNR1 | Ligand-receptor | Paracrine | Malignant cell | Cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | IL6 | Activation | SUCNR1 | Migration,EMT,Metastasis | Activation,Activation,Activation | Lung | Lung | Malignant | Cancer-associated | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 31735641 | Cancer-Derived Succinate Promotes Macrophage Polarization an... |
Molecular Cell | Jing Yiing Wu et al. | 2020 |
| TAC1 | Substance P | TACR1 | NK-1R | TAC1_TACR1 | Ligand-receptor | Paracrine | Neuron | Dorsal root ganglia | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | MMP1 | TAC1 Agonist | - | - | MMP1 | Activation | TAC | Migration,Invasion,Perineural invasion | Activation,Activation,Activation | - | Pancreas | Normal | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 29896303 | MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural ... |
Theranostics | Chumei Huang et al. | 2018 |
| TGFA | TGF-α | EGFR | - | TGFA_EGFR | Ligand-receptor | Paracrine | Fibroblast | Normal omental stromal fibroblast | Malignant cell | Metastatic ovarian cancer cell | Human,Mouse | - | - | - | - | - | - | EGF | Metastasis | Inhibition | Ovary | Ovary | Normal | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 28166193 | A loop of cancer-stroma-cancer interaction promotes peritone... |
Oncogene | T S Lau et al. | 2017 |
| TGFA | - | EGFR | - | TGFA_EGFR | Ligand-receptor | Autocrine | Malignant cell | Lung cancer cell | Malignant cell | Lung cancer cell | Human | - | - | - | - | VIM | Activation | EGF | Metastasis | Inhibition | Lung | Lung | Malignant | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 29339541 | PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR ... |
Cancer Research | Higinio Dopeso, Hui-Ke Jiao et al. | 2018 |
| TGFA | - | EGFR | - | TGFA_EGFR | Ligand-receptor | Paracrine | Malignant cell | Lung cancer cell | Malignant cell | Lung cancer cell | Human | - | - | - | - | VIM | Activation | EGF | Metastasis | Inhibition | Lung | Lung | Malignant | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 29339541 | PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR ... |
Cancer Research | Higinio Dopeso, Hui-Ke Jiao et al. | 2018 |
| TGFB1 | TGF-β1 | RGCC | RGC-32 | TGFB1_RGCC | Ligand-receptor | Paracrine | Malignant cell | Colon cancer cell | TAM | Tumor-associated Macrophage | Human,Mouse | - | - | - | - | - | - | TGFB1 | Migration,Tumor progression | Activation,Activation | Colon | Colon | Malignant | Cancer-associated | - | - | - | - | Colon Cancer | Colon Cancer | pubmed | 31601783 | Response gene to complement 32 expression in macrophages aug... |
Cell Death& Disease | Peng Zhao et al. | 2019 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic adenocarcinoma cell | Stellate cell | Pancreatic stellate cell | Human | - | - | - | - | IL1R1 | Inhibition | TGFb | - | - | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic adenocarcinoma | Pancreatic adenocarcinoma | pubmed | 27473228 | The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions b... |
Journal of Experimental & Clinical Cancer Research | Vegard Tjomsland et al. | 2016 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Pancreatic adenocarcinoma cell | Stellate cell | Pancreatic stellate cell | Human | - | - | - | - | IL1R1 | Inhibition | TGFb | - | - | Pancreas | Pancreas | Malignant | Normal | - | - | - | - | Pancreatic adenocarcinoma | Pancreatic adenocarcinoma | pubmed | 27473228 | The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions b... |
Journal of Experimental & Clinical Cancer Research | Vegard Tjomsland et al. | 2016 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | Myofibroblast | Bone marrow-derived myofibroblasts (BMFs) | Human | - | - | - | - | - | - | TGFB1 | Tumorigenesis | Activation | Stomach | Bone marrow | Malignant | Normal | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 27109105 | Crosstalk between bone marrow-derived myofibroblasts and gas... |
Oncogene | Liming Zhu et al. | 2016 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Gallbladder cancer cell | CAF | Cancer-associated Fibroblast | Human | - | - | - | - | TSP4 | Activation | - | GBC progression | Activation | Gallbladder | Gallbladder | Malignant | Cancer-associated | - | - | - | - | Gallbladder Cancer (GBC) | Gallbladder Cancer (GBC) | pubmed | 33407730 | Thrombospondin 4/integrin α2/HSF1 axis promotes proliferatio... |
Journal of Experimental & Clinical Cancer Research | Yu Shi et al. | 2021 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Human,Mouse | FERMT2 | TGFB1 Agonist | - | - | - | - | FERMT2 | Tumor growth | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28687620 | Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Ac... |
Cancer Research | Khalid Sossey-Alaoui et al. | 2017 |
| Tgfb1 | TGF-β1 | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Paracrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Mouse | - | - | - | - | - | - | OSR1 | EMT,Metastasis | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33051597 | OSR1 phosphorylates the Smad2/3 linker region and induces TG... |
Oncogene | Yang Li et al. | 2020 |
| TGFB1 | - | TGFBR1 | TGFBR | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Osteosarcoma cell | Stem cell | Mesenchymal stem cell | Human,Mouse | - | - | - | - | IL6 | Activation | - | Inducing a prometastatic phenotype | Inhibition | Bone | Bone | Malignant | Normal | - | - | - | - | Osteosarcoma and Undifferentiated Pleomorphic Sarc... |
Osteosarcoma | pubmed | 28053020 | Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosa... |
Clinical cancer research | S. Rubina Baglio et al. | 2017 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Ovary cancer cell | Mesothelial cell | Cancer-associated mesothelial cell | Human,Mouse | - | - | - | - | - | - | - | OPN expression,OPN secretion | Activation,Activation | Ovary | Ovary | Malignant | Malignant | - | - | - | - | Ovarian Cancer | Ovarian Cancer | pubmed | 34396988 | Cancer-associated mesothelial cells promote ovarian cancer c... |
The Journal of clinical investigation | Jin Qian et al. | 2021 |
| Tgfb1 | TGF-β | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Paracrine | Stem cell | Mesenchymal stem cell | Macrophage | Lipopolysaccharide-stimulated macrophage | Mouse | - | - | - | - | - | - | TGFb | Inflammation | Inhibition | - | - | Normal | Normal | - | - | - | - | Sepsis | Sepsis | pubmed | 31771622 | MSC-secreted TGF-β regulates lipopolysaccharide-stimulated m... |
Stem cell research & therapy | Feng Liu et al. | 2019 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | SNAI1,CDH2,CDH1 | Activation,Activation,Inhibition | TGFb | Migration,Invasion | Activation,Activation | Pancreas | Pancreas | Cancer-associated | Malignant | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 33428605 | Tumor-associated macrophages promote pancreatic ductal adeno... |
Aging | Cheng Xiong et al. | 2021 |
| TGFB1 | TGF-β1 | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | HAPLN1 | Activation | TGFb | ECM remodeling,Invasion | Activation,Activation | Stomach | Stomach | Malignant | Cancer-associated | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 34724589 | Cancer-associated fibroblasts-derived HAPLN1 promotes tumour... |
Gastric cancer : official journal of the International Gastr... |
Tiancheng Zhang et al. | 2021 |
| Tgfb1 | - | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Paracrine | Monocyte | Fetal Monocyte | Macrophage | PreAlveolar macrophage | Mouse | - | - | - | - | PPARG | Activation | TGFb | AM differentiation | Inhibition | Lung | Lung | Normal | Normal | - | - | - | - | - | - | pubmed | 29126797 | The Cytokine TGF-β Promotes the Development and Homeostasis ... |
Immunity | Xueyang Yu et al. | 2017 |
| Tgfb1 | - | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Autocrine | Macrophage | Alveolar macrophage | Macrophage | Alveolar macrophage | Mouse | - | - | - | - | - | - | TGFb | Self-maintenance | Inhibition | Lung | Lung | Normal | Normal | - | - | - | - | - | - | pubmed | 29126797 | The Cytokine TGF-β Promotes the Development and Homeostasis ... |
Immunity | Xueyang Yu et al. | 2017 |
| TGFB1 | TGFB | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | KLF5 acetylation,CXCR4 | Activation | TGFb | Bone metastasis,Chemoresistance | Activation,Activation | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33731701 | Acetylation of KLF5 maintains EMT and tumorigenicity to caus... |
Nature communications | Baotong Zhang et al. | 2021 |
| Tgfb1 | - | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Cancer stem cell | Tumor-initiating cell | Mouse | - | - | - | - | IL33 | Activation | TGFb | Tumor progression | Inhibition | Skin | Skin | Cancer-associated | Malignant | - | - | FcεRIα+ | - | Squamous cell carcinoma | Squamous cell carcinoma | pubmed | 32675345 | Tumor-initiating cells establish an IL-33-TGF-β niche signal... |
Science | Sachiko Taniguchi et al. | 2020 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Tumor cell | Human,Mouse | - | - | - | - | IL1B,CCL2 | Activation | NOTCH | Monocyte recruitment | Inhibition | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Basal-like breast cancer | Basal-like breast cancer | pubmed | 28790030 | Notch shapes the innate immunophenotype in breast cancer | Cancer Discovery | Qiang Shen et al. | 2017 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CLCF1 | Activation | TGFb | Tumor growth | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | TGFb | Self-renewal | Inhibition | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | TAN | Tumor-associated neutrophil | Human,Mouse | - | - | - | - | MPO,ROS1,ICAM1,FAS,TNF,TNFSF10 | Activation | TGFb | Polarization | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | N1 | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Breast cancer cell | Human,Mouse | - | - | - | - | CDK5 | Activation | TGFb | EMT,Metastasis | Activation,Activation | Breast | Breast | Cancer-associated | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 29325547 | Paracrine and epigenetic control of CAF-induced metastasis: ... |
Molecular Cancer | Yu Ren et al. | 2018 |
| TGFB1 | TGF-β1 | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | Malignant cell | Gastrointestinal stromal tumor cell | Fibroblast | Gastric fibroblast | Human,Mouse | - | - | - | - | - | - | TGFb | Migration,Metastasis | Activation,Activation | Stomach | Stomach | Malignant | Normal | - | - | - | - | Gastrointestinal Stromal Tumors (GIST) | Gastrointestinal Stromal Tumors (GIST) | pubmed | 33568624 | TGF-β1-mediated transition of resident fibroblasts to cancer... |
Oncogenesis | Hyunho Yoon et al. | 2021 |
| Tgfb1 | - | Tgfbr1 | - | Tgfb1_Tgfbr1 | Ligand-receptor | Paracrine | Macrophage | Bone marrow-derived macrophage | Stem cell | Adventitia stem/progenitor cell | Mouse | - | - | - | - | - | - | TGFb | SMC differentiation,Neointima hyperplasia | Activation,Activation | Bone marrow | Aorta | Normal | Normal | - | - | - | - | - | - | pubmed | 30778537 | Macrophage-derived MMP-8 determines smooth muscle cell diffe... |
Cardiovascular research | Feng Yang et al. | 2020 |
| TGFB1 | - | TGFBR1 | TGF-β type I receptor | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | MDSC | Myeloid-derived suppressor cell | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | IL6,IL22,TNF | Activation,Activation,Activation | KAT6A | Immune,Metastasis | Inhibition,Activation | Bone marrow | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 34392614 | KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppres... |
Advanced science | Bo Yu et al. | 2021 |
| TGFB1 | TGF-β1 | TGFBR1 | - | TGFB1_TGFBR1 | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Pancreatic ductal adenocarcinoma cell | Human,Mouse | - | - | - | - | NANOG,SOX2,OCT3/4 | Activation,Activation,Activation | TGFb | Stemness | Inhibition | Pancreas | Pancreas | Cancer-associated | Malignant | - | - | M2 | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 31199988 | Macrophage-expressed CD51 promotes cancer stem cell properti... |
Cancer Letters | Bin Zhang et al. | 2019 |
| TGFB1 | - | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Paracrine | T cell | Regulatory T cell | Cancer stem cell | Glioma stem cell | Human | - | - | - | - | IL6 | Activation | TGFB1 | - | - | Brain | Brain | Normal | Malignant | - | - | T Regulatory | - | Glioma | Glioma | pubmed | 33576874 | Regulatory T cells promote glioma cell stemness through TGF-... |
Cancer Immunology, Immunotherapy | Shasha Liu et al. | 2021 |
| TGFB1 | TGF-β1 | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | HAPLN1 | Activation | TGFb | ECM remodeling,Invasion | Activation,Activation | Stomach | Stomach | Malignant | Cancer-associated | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 34724589 | Cancer-associated fibroblasts-derived HAPLN1 promotes tumour... |
Gastric cancer : official journal of the International Gastr... |
Tiancheng Zhang et al. | 2021 |
| Tgfb1 | - | Tgfbr2 | - | Tgfb1_Tgfbr2 | Ligand-receptor | Paracrine | Monocyte | Fetal Monocyte | Macrophage | PreAlveolar macrophage | Mouse | - | - | - | - | PPARG | Activation | TGFb | AM differentiation | Inhibition | Lung | Lung | Normal | Normal | - | - | - | - | - | - | pubmed | 29126797 | The Cytokine TGF-β Promotes the Development and Homeostasis ... |
Immunity | Xueyang Yu et al. | 2017 |
| Tgfb1 | - | Tgfbr2 | - | Tgfb1_Tgfbr2 | Ligand-receptor | Autocrine | Macrophage | Alveolar macrophage | Macrophage | Alveolar macrophage | Mouse | - | - | - | - | - | - | TGFb | Self-maintenance | Inhibition | Lung | Lung | Normal | Normal | - | - | - | - | - | - | pubmed | 29126797 | The Cytokine TGF-β Promotes the Development and Homeostasis ... |
Immunity | Xueyang Yu et al. | 2017 |
| TGFB1 | TGFB | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | KLF5 acetylation,CXCR4 | Activation | TGFb | Bone metastasis,Chemoresistance | Activation,Activation | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 33731701 | Acetylation of KLF5 maintains EMT and tumorigenicity to caus... |
Nature communications | Baotong Zhang et al. | 2021 |
| TGFB1 | - | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CLCF1 | Activation | TGFb | Tumor growth | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | TGFb | Self-renewal | Inhibition | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | TAN | Tumor-associated neutrophil | Human,Mouse | - | - | - | - | MPO,ROS1,ICAM1,FAS,TNF,TNFSF10 | Activation | TGFb | Polarization | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | N1 | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | TGF-β1 | TGFBR2 | - | TGFB1_TGFBR2 | Ligand-receptor | Paracrine | Malignant cell | Gastrointestinal stromal tumor cell | Fibroblast | Gastric fibroblast | Human,Mouse | - | - | - | - | - | - | TGFb | Migration,Metastasis | Activation,Activation | Stomach | Stomach | Malignant | Normal | - | - | - | - | Gastrointestinal Stromal Tumors (GIST) | Gastrointestinal Stromal Tumors (GIST) | pubmed | 33568624 | TGF-β1-mediated transition of resident fibroblasts to cancer... |
Oncogenesis | Hyunho Yoon et al. | 2021 |
| TGFB1 | - | TGFBR3 | - | TGFB1_TGFBR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | CLCF1 | Activation | TGFb | Tumor growth | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR3 | - | TGFB1_TGFBR3 | Ligand-receptor | Autocrine | Malignant cell | Hepatocellular carcinoma cell | Malignant cell | Hepatocellular carcinoma cell | Human,Mouse | - | - | - | - | - | - | TGFb | Self-renewal | Inhibition | Liver | Liver | Malignant | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB1 | - | TGFBR3 | - | TGFB1_TGFBR3 | Ligand-receptor | Paracrine | Malignant cell | Hepatocellular carcinoma cell | TAN | Tumor-associated neutrophil | Human,Mouse | - | - | - | - | MPO,ROS1,ICAM1,FAS,TNF,TNFSF10 | Activation | TGFb | Polarization | Inhibition | Liver | Liver | Malignant | Cancer-associated | - | - | - | N1 | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 33682185 | Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Sup... |
Hepatology | Mengjia Song et al. | 2021 |
| TGFB2 | - | TGFBR2 | - | TGFB2_TGFBR2 | Ligand-receptor | Autocrine | Malignant cell | Triple-negative breast cancer cell | Malignant cell | Triple Negative Breast Cancer cell | Human | - | - | - | - | SMAD2/3 | Activation | - | Metastasis | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 28692037 | SRGN-TGFß2 regulatory loop confers invasion and metastasis i... |
Oncogenesis | Z Zhang et al. | 2017 |
| TGFB2 | TGF-β2 | TGFBR2 | - | TGFB2_TGFBR2 | Ligand-receptor | Paracrine | TAN | Tumor-associated Neutrophil | Cancer stem cell | Hepatocellular carcinoma stem-like cell | Human | - | - | - | - | CXCL5 | Activation | TGFb | Proliferation,Invasion | Activation,Activation | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30933361 | A Positive Feedback Loop between Cancer Stem-Like Cells and ... |
Hepatology | Shao‐Lai Zhou et al. | 2019 |
| THBS4 | - | ITGA2 | - | THBS4_ITGA2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Gallbladder cancer cell | Human | - | - | - | - | TGFB1 | Activation | PI3K | Invasion,Metastasis,Cancer stemness | Activation,Activation,Activation | Gallbladder | Gallbladder | Cancer-associated | Malignant | - | - | - | - | Gallbladder Cancer (GBC) | Gallbladder Cancer (GBC) | pubmed | 33407730 | Thrombospondin 4/integrin α2/HSF1 axis promotes proliferatio... |
Journal of Experimental & Clinical Cancer Research | Yu Shi et al. | 2021 |
| THY1 | CD90 | ITGB2 | Mac-1 | THY1_ITGB2 | Ligand-receptor | Juxtacrine | Malignant cell | Tumor cell | Neutrophil | Parenchymal neutrophil | Human | - | - | - | - | TIMP1 | Activation | THY1 | Breast cancer metastasis | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 30482778 | Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIM... |
Clinical Cancer Research | Ying Wang et al. | 2019 |
| TINAGL1 | Tinagl1 | EGFR | - | TINAGL1_EGFR | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | Integrin/FAK | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | EGFR | - | TINAGL1_EGFR | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | EGFR | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGA5 | - | TINAGL1_ITGA5 | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | Integrin/FAK | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGA5 | - | TINAGL1_ITGA5 | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | EGFR | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGAV | - | TINAGL1_ITGAV | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | Integrin/FAK | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGAV | - | TINAGL1_ITGAV | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | EGFR | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGB1 | - | TINAGL1_ITGB1 | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | Integrin/FAK | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGB1 | - | TINAGL1_ITGB1 | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | EGFR | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TINAGL1 | Tinagl1 | ITGB1 | - | TINAGL1_ITGB1 | ECM-receptor | - | ECM | - | Malignant cell | Triple Negative Breast Cancer cell | Human,Mouse | - | - | - | - | - | - | TINAGL1 | Progression | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Triple-negative breast cancer | Triple-negative breast cancer | pubmed | 30612941 | Tinagl1 Suppresses Triple-Negative Breast Cancer Progression... |
Cancer cell | Minhong Shen et al. | 2019 |
| TNC | - | ITGA2 | - | TNC_ITGA2 | Ligand-receptor | Autocrine | Cancer stem cell | Brain tumor-initiating cell | Cancer stem cell | Brain tumor-initiating cell | Human,Mouse | - | - | - | - | TNC | Activation | TENASCIN | Tumor growth | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 28416488 | Activation of NOTCH Signaling by Tenascin-C Promotes Growth ... |
Cancer Research | Susobhan Sarkar et al. | 2017 |
| TNC | - | ITGB1 | - | TNC_ITGB1 | Ligand-receptor | Autocrine | Cancer stem cell | Brain tumor-initiating cell | Cancer stem cell | Brain tumor-initiating cell | Human,Mouse | - | - | - | - | TNC | Activation | TENASCIN | Tumor growth | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 28416488 | Activation of NOTCH Signaling by Tenascin-C Promotes Growth ... |
Cancer Research | Susobhan Sarkar et al. | 2017 |
| TNF | - | TNFRSF1A | - | TNF_TNFRSF1A | Ligand-receptor | Paracrine | T cell | CD4+ T effector memory T cell | Stem cell | Intestinal stem cell | Human | - | - | - | - | - | - | TNF | ISC proliferation | Inhibition | Fetal intestine | Fetal intestine | Normal | Normal | - | - | CD4+ T effector memory | - | Necrotizing enterocolitis | Necrotizing enterocolitis | pubmed | 30770246 | Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T... |
Immunity | Renée R C E Schreurs et al. | 2019 |
| TNF | - | TNFRSF1A | - | TNF_TNFRSF1A | Ligand-receptor | Paracrine | T cell | CD4+ T effector memory T cell | Stem cell | Intestinal stem cell | Human | - | - | - | - | - | - | TNF | ISC proliferation | Inhibition | Fetal intestine | Fetal intestine | Normal | Normal | - | - | CD4+ T effector memory | - | Necrotizing enterocolitis | Necrotizing enterocolitis | pubmed | 30770246 | Human Fetal TNF-α-Cytokine-Producing CD4 + Effector Memory T... |
Immunity | Renée R C E Schreurs et al. | 2019 |
| TNF | TNF-α | TNFRSF1A | TNFR1 | TNF_TNFRSF1A | Ligand-receptor | Paracrine | Malignant cell | Pancreatic ductal adenocarcinoma cell | CAF | Tumor-associated Fibroblast | Human | - | - | - | - | GPR68,IL6 | Activation,Activation | TNF | Proliferation | Inhibition | Pancreas | Pancreas | Malignant | Cancer-associated | - | - | - | - | Pancreatic ductal adenocarcinoma | Pancreatic ductal adenocarcinoma | pubmed | 29092903 | GPR68, a proton-sensing GPCR, mediates interaction of cancer... |
FASEB journal : official publication of the Federation of Am... |
Shu Z Wiley et al. | 2018 |
| TNF | TNFA | TNFRSF1A | TNFR1 | TNF_TNFRSF1A | Ligand-receptor | Paracrine | Macrophage | Macrophage | Malignant cell | Breast cancer cell | Human | - | - | - | - | HK2 | Activation | TNF | Migration | Inhibition | Breast | Breast | Normal | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 28945218 | TNF-α-YAP/p65-HK2 axis mediates breast cancer cell migration | Oncogenesis | Y Gao et al. | 2017 |
| TNF | TNF-α | TNFRSF1B | TNFR2 | TNF_TNFRSF1B | Ligand-receptor | Paracrine | Malignant cell | Gastric cancer cell | CAF | Cancer-associated Fibroblast | Human,Mouse | - | - | - | - | IL33 | Activation | TNF | - | - | Stomach | Stomach | Malignant | Cancer-associated | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 31659258 | The reciprocal interaction between tumor cells and activated... |
Oncogene | Quan Zhou et al. | 2020 |
| TNFRSF14 | HVEM | BTLA | - | TNFRSF14_BTLA | Ligand-receptor | Juxtacrine | B cell | Antigen-presenting cell | T cell | T cell | Human,Mouse | - | - | - | - | PTPN6 | Activation | BTLA | T cell signaling | Inhibition | Spleen | Blood | Normal | Normal | - | - | - | CD8+ | - | - | pubmed | 32437509 | PD-1 and BTLA regulate T cell signaling differentially and o... |
The Journal of cell biology | Xiaozheng Xu et al. | 2020 |
| TNFSF10 | TRAIL | TNFRSF10A | DR4 | TNFSF10_TNFRSF10A | Ligand-receptor | Paracrine | Adipocyte | Adipocyte | T cell | T lymphocyte | Human | - | - | - | - | TL1A,TNFRSF10A,TNFRSF10B | Activation,Activation,Activation | TRAIL | - | - | Visceral adipose tissue | Visceral adipose tissue | Normal | Normal | - | - | - | - | Obesity | Obesity | pubmed | 32732304 | A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macroph... |
Diabetes | Nitzan Maixner et al. | 2020 |
| TNFSF10 | TRAIL | TNFRSF10B | DR5 | TNFSF10_TNFRSF10B | Ligand-receptor | Paracrine | Adipocyte | Adipocyte | T cell | T lymphocyte | Human | - | - | - | - | TL1A,TNFRSF10A,TNFRSF10B | Activation,Activation,Activation | TRAIL | - | - | Visceral adipose tissue | Visceral adipose tissue | Normal | Normal | - | - | - | - | Obesity | Obesity | pubmed | 32732304 | A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macroph... |
Diabetes | Nitzan Maixner et al. | 2020 |
| TNFSF11 | - | TNFRSF11A | - | TNFSF11_TNFRSF11A | Ligand-receptor | Juxtacrine | Stromal cell | Decidual stromal cell | T cell | Decidual γδ Τ cell | Human,Mouse | - | - | - | - | TGFB1 | Activation | NFKB1 | Preventing pregnancy loss | Inhibition | Decidua | Blood | Normal | Normal | - | - | - | Decidual γδ | - | - | pubmed | 30737372 | Decidual RANKL/RANK interaction promotes the residence and p... |
Cell Death & Disease | Rui-Qi Chang et al. | 2019 |
| TNFSF11 | - | TNFRSF11A | - | TNFSF11_TNFRSF11A | Ligand-receptor | Juxtacrine | Stem cell | Bone marrow mesenchymal stem cell | Stem cell | Bone marrow mesenchymal stem cell | Human,Mouse | - | - | - | - | WNT,CTNNB1 | Inhibition,Inhibition | NFKB1 | Osteogenic differentiation of BMSCs,Osteoclastogenesis | Inhibition,Activation | Bone | Bone | Normal | Normal | - | - | - | - | - | - | pubmed | 30510839 | RANKL signaling in bone marrow mesenchymal stem cells negati... |
Bone Research | Xiao Chen et al. | 2018 |
| TNFSF12 | TWEAK | TNFRSF12A | Fn14 | TNFSF12_TNFRSF12A | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Cholangiocarcinoma cell | Human | - | - | - | - | CCL2 | Activation | TWEAK | Tumor growth | Inhibition | Liver | Liver | Cancer-associated | Malignant | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 33221352 | TWEAK/Fn14 signalling promotes cholangiocarcinoma niche form... |
Journal of hepatology | Benjamin J Dwyer et al. | 2021 |
| TNFSF12 | TWEAK | TNFRSF12A | Fn14 | TNFSF12_TNFRSF12A | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | CAF | Cancer-associated Fibroblast | Human | - | - | - | - | - | - | TWEAK | Proliferation | Inhibition | Liver | Liver | Cancer-associated | Cancer-associated | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 33221352 | TWEAK/Fn14 signalling promotes cholangiocarcinoma niche form... |
Journal of hepatology | Benjamin J Dwyer et al. | 2021 |
| TNFSF15 | TL1A | TNFRSF25 | DR3 | TNFSF15_TNFRSF25 | Ligand-receptor | Paracrine | T cell | T lymphocyte | Adipocyte | Adipocyte | Human | - | - | - | - | E2F1 | Activation | VEGI | Adipocyte dysfunction,Obesity | Activation,Activation | Visceral adipose tissue | Visceral adipose tissue | Normal | Normal | - | - | - | - | Obesity | Obesity | pubmed | 32732304 | A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macroph... |
Diabetes | Nitzan Maixner et al. | 2020 |
| TNFSF15 | TL1A | TNFRSF25 | DR3 | TNFSF15_TNFRSF25 | Ligand-receptor | Paracrine | T cell | T lymphocyte | Macrophage | Adipose tissue macrophage | Human | - | - | - | - | - | - | VEGI | Adipocyte dysfunction,Obesity | Activation,Activation | Visceral adipose tissue | Visceral adipose tissue | Normal | Normal | - | - | - | - | Obesity | Obesity | pubmed | 32732304 | A TRAIL-TL1A Paracrine Network Involving Adipocytes, Macroph... |
Diabetes | Nitzan Maixner et al. | 2020 |
| TNFSF9 | CD137L | TNFRSF9 | CD137 | TNFSF9_TNFRSF9 | Ligand-receptor | Paracrine | Dendritic cell | CD11b-CD103+dendritic cell | Dendritic cell | CD11b+CD103−dendritic cell | Human,Mouse | - | - | - | - | IL23A | Inhibition | CD137 | - | - | Colon | Colon | Normal | Normal | - | - | CD11b - CD103 + | CD11b + CD103 - | - | - | pubmed | 32209473 | CD137 Signaling Regulates Acute Colitis via RALDH2-Expressin... |
Cell Report | Jing Jin et al. | 2020 |
| VCAM1 | VCAM-1 | ITGA4 | VLA-4 | VCAM1_ITGA4 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Lung cancer cell | Human | - | - | - | - | - | - | VCAM | Proliferation,Invasion,Migration | Activation,Activation,Activation | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 31904479 | VCAM-1 secreted from cancer-associated fibroblasts enhances ... |
Cancer letters | Zhuan Zhou et al. | 2020 |
| VCAM1 | VCAM-1 | ITGB1 | VLA-4 | VCAM1_ITGB1 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Lung cancer cell | Human | - | - | - | - | - | - | VCAM | Proliferation,Invasion,Migration | Activation,Activation,Activation | Lung | Lung | Cancer-associated | Malignant | - | - | - | - | Lung Cancer | Lung Cancer | pubmed | 31904479 | VCAM-1 secreted from cancer-associated fibroblasts enhances ... |
Cancer letters | Zhuan Zhou et al. | 2020 |
| VCAM1 | - | ITGB1 | - | VCAM1_ITGB1 | Ligand-receptor | Juxtacrine | Neutrophil | Neutrophil | Epithelial cell | Cholangiocyte | Human | - | - | - | - | ITPR3 | Inhibition | VCAM | Cholestasis | Inhibition | Liver | Liver | Normal | Normal | - | - | - | - | Alcoholic hepatitis (AH) | Alcoholic hepatitis (AH) | pubmed | 33214166 | Neutrophils interact with cholangiocytes to cause cholestati... |
Gut | Masahiro Takeuchi et al. | 2020 |
| VEGFA | VEGF | FLT1 | VEGFR1 | VEGFA_FLT1 | Ligand-receptor | Paracrine | Malignant cell | Medulloblastoma cell | Endothelial cell | Vascular endothelial cell | Human,Mouse | - | - | - | - | - | - | VEGF | Angiogenesis | Inhibition | Cerebellum | Cerebellum | Malignant | Normal | - | - | - | - | Medulloblastoma (MB) | Medulloblastoma (MB) | pubmed | 33469989 | REST promotes ETS1-dependent vascular growth in medulloblast... |
Molecular oncology | Shavali Shaik et al. | 2021 |
| VEGFA | - | KDR | - | VEGFA_KDR | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Endothelial cell | Lymphatic endothelial cell | Human | - | - | - | - | - | - | VEGF | Tumor-associated lymphangiogenesis | Activation,Activation | Liver | Lymph | Cancer-associated | Normal | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 30553841 | Platelet-derived growth factor-D enables liver myofibroblast... |
Journal of hepatology | Massimiliano Cadamuro et al. | 2019 |
| Vegfa | - | Kdr | VEGFR | Vegfa_Kdr | Ligand-receptor | Paracrine | Malignant cell | Renal cell carcinoma (RCC) cell | Endothelial cell | Endothelial cell | Mouse | RAC1 | Vegfa Agonist | - | - | - | - | MAPK | Angiogenesis | Inhibition | Kidney | Kidney | Malignant | Normal | - | - | - | - | Clear cell renal cell carcinoma (ccRCC) | Clear cell renal cell carcinoma (ccRCC) | pubmed | 32371578 | Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth... |
Molcular Cancer Therapeutics | Erik T Goka et al. | 2020 |
| VEGFA | - | KDR | VEGFR2 | VEGFA_KDR | Ligand-receptor | Autocrine | Endothelial cell | Endothelial cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | ADAM12,HBEGF | Activation,Activation | VEGF | Cardiomyocyte growth | Inhibition | Heart | Heart | Normal | Normal | - | - | - | - | Cardiac Hypertrophy | Cardiac Hypertrophy | pubmed | 30922063 | Endothelial Cells Regulate Physiological Cardiomyocyte Growt... |
Circulation | Riikka Kivelä et al. | 2019 |
| VEGFA | - | KDR | VEGFR | VEGFA_KDR | Ligand-receptor | Paracrine | Cancer stem cell | Breast cancer stem cell | Endothelial cell | TME-derived endothelial cell | Human,Mouse | - | - | - | - | JAG1 | Activation | VEGFA | Angiogenesis | Inhibition | Breast | Breast | Malignant | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33046710 | Jagged1-Notch1-deployed tumor perivascular niche promotes br... |
Nature communications | Huimin Jiang et al. | 2020 |
| VEGFA | - | NRP2 | - | VEGFA_NRP2 | Ligand-receptor | Autocrine | Malignant cell | Lung adenocarcinoma cell | Malignant cell | Lung adenocarcinoma cell | Human,Mouse | - | - | - | - | VEGFA,NRP2 | Activation | NRP2 | Tumor growth,Stemness | Activation,Activation | Lung | Lung | Malignant | Malignant | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 28368412 | Noncanonical GLI1 signaling promotes stemness features and i... |
Oncogene | A Po et al. | 2017 |
| VEGFA | - | NRP2 | - | VEGFA_NRP2 | Ligand-receptor | Paracrine | Stromal cell | Stromal cell | Malignant cell | Lung adenocarcinoma cell | Human,Mouse | - | - | - | - | VEGFA,NRP2 | Activation | NRP2 | Tumor growth,Stemness | Activation,Activation | Lung | Lung | Normal | Malignant | - | - | - | - | Lung adenocarcinoma | Lung adenocarcinoma | pubmed | 28368412 | Noncanonical GLI1 signaling promotes stemness features and i... |
Oncogene | A Po et al. | 2017 |
| Vegfa | - | Nrp2 | Neuropilin-2 | Vegfa_Nrp2 | Ligand-receptor | Autocrine | Malignant cell | Breast cancer cell | Malignant cell | Breast cancer cell | Mouse | - | - | - | - | - | - | VEGF | Proliferation,Survival | Activation,Activation | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 29717062 | VEGF-neuropilin-2 signaling promotes stem-like traits in bre... |
Science signaling | Ameer L Elaimy et al. | 2018 |
| Vegfa | - | Vegfr | - | Vegfa_Vegfr | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Hepatocellular carcinoma cell | Mouse | - | - | - | - | CDH2 | Activation | VEGF | EMT | Inhibition | Liver | Liver | Cancer-associated | Malignant | - | - | M2 | - | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 30180849 | NFE2L2 activation drive macrophages polarization and cancer ... |
Cell Communication and Signaling | Rui Feng et al. | 2018 |
| Vegfa | - | Vegfr | - | Vegfa_Vegfr | Ligand-receptor | Paracrine | TAM | Tumor-associated Macrophage | Malignant cell | Pancreatic cancer cell | Mouse | - | - | - | - | CDH2 | Activation | VEGF | EMT | Inhibition | Pancreas | Pancreas | Cancer-associated | Malignant | - | - | M2 | - | Pancreatic Cancer | Pancreatic Cancer | pubmed | 30180849 | NFE2L2 activation drive macrophages polarization and cancer ... |
Cell Communication and Signaling | Rui Feng et al. | 2018 |
| VEGFB | - | FLT1 | VEGFR1 | VEGFB_FLT1 | Ligand-receptor | Paracrine | Cardiomyocyte | Cardiomyocyte | Endothelial cell | Endothelial cell | Human,Mouse | - | - | - | - | - | - | VEGF | Cardiomyocyte growth | - | Heart | Heart | Normal | Normal | - | - | - | - | Cardiac Hypertrophy | Cardiac Hypertrophy | pubmed | 30922063 | Endothelial Cells Regulate Physiological Cardiomyocyte Growt... |
Circulation | Riikka Kivelä et al. | 2019 |
| VEGFC | - | FLT4 | - | VEGFC_FLT4 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Endothelial cell | Lymphatic endothelial cell | Human | - | - | - | - | - | - | VEGF | Metastasis | Activation,Activation | Liver | Lymph | Cancer-associated | Normal | - | - | - | - | Cholangiocarcinoma | Cholangiocarcinoma | pubmed | 30553841 | Platelet-derived growth factor-D enables liver myofibroblast... |
Journal of hepatology | Massimiliano Cadamuro et al. | 2019 |
| VEGFC | - | FLT4 | - | VEGFC_FLT4 | Ligand-receptor | Autocrine | Malignant cell | Oral squamous cell carcinoma cell | Malignant cell | Oral squamous cell carcinoma cell | Human,Mouse | - | - | - | - | CNTN1,VEGFC | Activation,Activation | VEGF | Migration | Inhibition | Oral | Oral | Malignant | Malignant | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 30416855 | VEGF-C/Flt-4 axis in tumor cells contributes to the progress... |
American journal of cancer research | Seiji Shigetomi et al. | 2018 |
| VEGFC | - | FLT4 | - | VEGFC_FLT4 | Ligand-receptor | Paracrine | Malignant cell | Oral squamous cell carcinoma cell | Endothelial cell | Lymphatic endothelial cell | Human,Mouse | - | - | - | - | - | - | VEGF | Lymphangiogenesis | Inhibition | Oral | Lymph | Malignant | Normal | - | - | - | - | Oral squamous cell carcinoma | Oral squamous cell carcinoma | pubmed | 30416855 | VEGF-C/Flt-4 axis in tumor cells contributes to the progress... |
American journal of cancer research | Seiji Shigetomi et al. | 2018 |
| VEGFC | VEGF-C | FLT4 | VEGFR3_NRP2 | VEGFC_FLT4 | Ligand-receptor | Paracrine | Malignant cell | EMT-epithelial breast cancer cell | Malignant cell | Epithelial breast cancer cell | Human,Mouse | - | - | - | - | - | - | VEGFC | Progression | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33299122 | VEGF-C mediates tumor growth and metastasis through promotin... |
Oncogene | Deguang Kong et al. | 2021 |
| Vegfc | - | Flt4 | VEGFR3 | Vegfc_Flt4 | Ligand-receptor | Paracrine | B cell | Eμ-Myc B-cell | Endothelial cell | Blood endothelial cell | Mouse | - | - | - | - | - | - | FLT4 | Angiogenesis | Inhibition | Blood | Blood | Malignant | Normal | - | - | - | - | Lymphoma | Lymphoma | pubmed | 31932457 | Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signal... |
Cancer Research | Marleen Gloger et al. | 2020 |
| VEGFC | - | KDR | VEGFR | VEGFC_KDR | Ligand-receptor | Autocrine | Endothelial cell | Lymphatic endothelial cell | Endothelial cell | Lymphatic endothelial cell | Human | - | - | - | - | - | - | VEGF | Lymphangiogenesis,Metastasis | Activation,Activation | Lymph | Lymph | Normal | Normal | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 27353364 | Lipocalin 2 from macrophages stimulated by tumor cell-derive... |
Science signaling | Michaela Jung et al. | 2016 |
| VEGFC | - | KDR | - | VEGFC_KDR | Ligand-receptor | Autocrine | Malignant cell | Glioblastoma cell | Malignant cell | Glioblastoma cell | Human | - | - | - | - | - | - | VEGF | Survival,Proliferation,Cell cycle progression | Activation,Activation,Activation | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 29939339 | VEGF-C sustains VEGFR2 activation under bevacizumab therapy ... |
Neuro-oncology | Signe R Michaelsen et al. | 2018 |
| VEGFC | - | KDR | - | VEGFC_KDR | Ligand-receptor | Paracrine | Malignant cell | Glioblastoma cell | Endothelial cell | Infiltrative non-cancer cell (Endothelial cell) | Human | - | - | - | - | - | - | VEGF | Survival,Proliferation,Cell cycle progression | Activation,Activation,Activation | Brain | Vascular | Malignant | Normal | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 29939339 | VEGF-C sustains VEGFR2 activation under bevacizumab therapy ... |
Neuro-oncology | Signe R Michaelsen et al. | 2018 |
| VEGFC | - | KDR | - | VEGFC_KDR | Ligand-receptor | Paracrine | Malignant cell | Glioblastoma cell | Endothelial cell | Infiltrative non-cancer cell (Endothelial cell) | Human | - | - | - | - | - | - | VEGF | Survival,Proliferation,Cell cycle progression | Activation,Activation,Activation | Brain | Lymph | Malignant | Normal | - | - | - | - | Glioblastoma | Glioblastoma | pubmed | 29939339 | VEGF-C sustains VEGFR2 activation under bevacizumab therapy ... |
Neuro-oncology | Signe R Michaelsen et al. | 2018 |
| VEGFC | VEGF-C | NRP2 | VEGFR3_NRP2 | VEGFC_NRP2 | Ligand-receptor | Paracrine | Malignant cell | EMT-epithelial breast cancer cell | Malignant cell | Epithelial breast cancer cell | Human,Mouse | - | - | - | - | - | - | VEGFC | Progression | Inhibition | Breast | Breast | Malignant | Malignant | - | - | - | - | Breast Cancer | Breast Cancer | pubmed | 33299122 | VEGF-C mediates tumor growth and metastasis through promotin... |
Oncogene | Deguang Kong et al. | 2021 |
| VIP | - | VIPR1 | VPAC1 | VIP_VIPR1 | Ligand-receptor | Autocrine | Malignant cell | Gastric cancer cell | Malignant cell | Gastric cancer cell | Human | - | - | - | - | VIP | Activation | VIP | Invasion,Metastasis | Activation,Activation | Stomach | Stomach | Malignant | Malignant | - | - | - | - | Gastric Cancer | Gastric Cancer | pubmed | 30692637 | VPAC1 couples with TRPV4 channel to promote calcium-dependen... |
Oncogene | Bo Tang et al. | 2019 |
| VTCN1 | B7S1 | B7S1R | - | VTCN1_B7S1R | Ligand-receptor | Juxtacrine | B cell | Antigen-presenting cell | T cell | CD8+ T cell | Human,Mouse | - | - | - | - | Eomes | Activation | VTCN1 | Dysfunction of Anti-tumor CD8+T cell | Inhibition | Liver | Liver | Normal | Normal | - | - | - | CD8+ | Hepatocellular carcinoma | Hepatocellular carcinoma | pubmed | 29625896 | Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by ... |
Immunity | Jing Li et al. | 2018 |
| WFDC2 | - | EGFR | - | WFDC2_EGFR | Ligand-receptor | Autocrine | Malignant cell | Prostate cancer cell | Malignant cell | Prostate cancer cell | Human,Mouse | - | - | - | - | CDH1 | Activation | WFDC2 | EMT,Metastasis | Inhibition,Inhibition | Prostate | Prostate | Malignant | Malignant | - | - | - | - | Prostate Cancer | Prostate Cancer | pubmed | 32678075 | WFDC2 suppresses prostate cancer metastasis by modulating EG... |
Cell Death Disease | Yaoyi Xiong et al. | 2020 |
| WNT11 | - | FZD7 | - | WNT11_FZD7 | Ligand-receptor | Autocrine | Melanocyte | Amoeboid melanoma cell | Melanocyte | Amoeboid melanoma cell | Human,Mouse | - | - | - | - | - | - | ncWNT | Tumor initiation,Proliferation | Activation,Activation | Skin | Skin | Malignant | Malignant | - | - | - | - | Melanoma | Melanoma | pubmed | 33082334 | WNT11-FZD7-DAAM1 signalling supports tumour initiating abili... |
Nature communications | Irene Rodriguez-Hernandez et al. | 2020 |
| WNT2 | - | FZD2 | - | WNT2_FZD2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Esophageal squamous cell | Human,Mouse | - | - | - | - | SNAI2 | Activation | WNT2 | Invasion,Migration,Metastasis | Activation,Activation,Activation | Esophagus | Esophagus | Cancer-associated | Malignant | - | - | - | - | Esophageal squamous cell carcinoma | Esophageal squamous cell carcinoma | pubmed | 32766155 | WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer... |
Frontiers in Oncology | Yufei Fu et al. | 2020 |
| WNT2 | - | FZD2 | - | WNT2_FZD2 | Ligand-receptor | Paracrine | CAF | Cancer-associated Fibroblast | Malignant cell | Esophageal squamous cell | Human,Mouse | - | - | - | - | TWIST1 | Activation | WNT2 | Invasion,Migration,EMT | Activation,Activation,Activation | Esophagus | Esophagus | Cancer-associated | Malignant | - | - | - | - | Esophageal squamous cell carcinoma | Esophageal squamous cell carcinoma | pubmed | 32766155 | WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer... |
Frontiers in Oncology | Yufei Fu et al. | 2020 |
| WNT5A | Wnt5a | FZD1 | - | WNT5A_FZD1 | Ligand-receptor | Paracrine | Melanocyte | Melanocyte | Dendritic cell | Dendritic cell | Human | - | - | - | - | - | - | ncWNT | Immune invasion | Inhibition | Skin | Lymph | Malignant | Normal | - | - | - | - | Melanoma | Melanoma | pubmed | 29343435 | Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Pro... |
Immunity | Fei Zhao et al. | 2018 |
| WNT5A | - | FZD4 | Frizzled-4 | WNT5A_FZD4 | Ligand-receptor | Paracrine | Endothelial cell | Endothelial cell | Cancer stem cell | Glioma stem cell | Human | - | - | - | - | CD31,CD34,MMP9,MMP14 | Activation,Activation,Activation,Activation | WNT5A | Endothelial differentiation,Angiogenesis | Activation,Activation | Brain | Brain | Normal | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 34188250 | Dual role of WNT5A in promoting endothelial differentiation ... |
Oncogene | Taoliang Chen et al. | 2021 |
| WNT5A | - | FZD4 | Frizzled-4 | WNT5A_FZD4 | Ligand-receptor | Autocrine | TEC | Glioma derived endothelial cell | Endothelial cell | Glioma derived endothelial cell | Human | - | - | - | - | CD31,CD34,MMP9,MMP14 | Activation,Activation,Activation,Activation | WNT5A | Angiogenesis | Inhibition | Brain | Brain | Malignant | Malignant | - | - | - | - | Glioma | Glioma | pubmed | 34188250 | Dual role of WNT5A in promoting endothelial differentiation ... |
Oncogene | Taoliang Chen et al. | 2021 |
| WNT5B | - | FZD7 | - | WNT5B_FZD7 | Ligand-receptor | Autocrine | Melanocyte | Amoeboid melanoma cell | Melanocyte | Amoeboid melanoma cell | Human,Mouse | - | - | - | - | - | - | ncWNT | Tumor initiation,Proliferation | Activation,Activation | Skin | Skin | Malignant | Malignant | - | - | - | - | Melanoma | Melanoma | pubmed | 33082334 | WNT11-FZD7-DAAM1 signalling supports tumour initiating abili... |
Nature communications | Irene Rodriguez-Hernandez et al. | 2020 |
| WNT7A | - | ADGRA2 | - | WNT7A_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | FZD | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7A | - | ADGRA2 | - | WNT7A_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP5 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7A | - | ADGRA2 | - | WNT7A_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP6 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7A | - | RECK | - | WNT7A_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | FZD | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7A | - | RECK | - | WNT7A_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP5 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7A | - | RECK | - | WNT7A_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP6 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | ADGRA2 | - | WNT7B_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | FZD | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | ADGRA2 | - | WNT7B_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP5 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | ADGRA2 | - | WNT7B_ADGRA2 | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP6 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | RECK | - | WNT7B_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | FZD | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | RECK | - | WNT7B_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP5 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |
| WNT7B | - | RECK | - | WNT7B_RECK | Ligand-receptor | Paracrine | Neuron | Neural cell | Endothelial cell | Endothelial cell | Human,Mouse | - | - | LRP6 | WNT activation receptor | - | - | WNT7 | Blood-brain barrier formation | Inhibition | Brain | Brain | Normal | Normal | - | - | - | - | - | - | pubmed | 30304675 | A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Spec... |
Cell report | Mario Vallon et al. | 2018 |